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Fusion gene ID: 13768 |
FusionGeneSummary for FOXK1_RCL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FOXK1_RCL1 | Fusion gene ID: 13768 | Hgene | Tgene | Gene symbol | FOXK1 | RCL1 | Gene ID | 221937 | 10171 |
| Gene name | forkhead box K1 | RNA terminal phosphate cyclase like 1 | |
| Synonyms | FOXK1L | RNAC|RPCL1 | |
| Cytomap | 7p22.1 | 9p24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | forkhead box protein K1MNFmyocyte nuclear factor | RNA 3'-terminal phosphate cyclase-like proteinRNA cyclase homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P85037 | Q9Y2P8 | |
| Ensembl transtripts involved in fusion gene | ENST00000446823, ENST00000328914, | ENST00000381750, ENST00000381730, ENST00000381728, ENST00000448872, ENST00000381732, ENST00000445485, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 6 X 5 X 6=180 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FOXK1 [Title/Abstract] AND RCL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI030352 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000446823 | ENST00000381750 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-intron | ENST00000446823 | ENST00000381730 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-intron | ENST00000446823 | ENST00000381728 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-intron | ENST00000446823 | ENST00000448872 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-intron | ENST00000446823 | ENST00000381732 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-intron | ENST00000446823 | ENST00000445485 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-3CDS | ENST00000328914 | ENST00000381750 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-intron | ENST00000328914 | ENST00000381730 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-intron | ENST00000328914 | ENST00000381728 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-intron | ENST00000328914 | ENST00000448872 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-intron | ENST00000328914 | ENST00000381732 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
| intron-intron | ENST00000328914 | ENST00000445485 | FOXK1 | chr7 | 4765581 | - | RCL1 | chr9 | 4826981 | - |
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FusionProtFeatures for FOXK1_RCL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FOXK1 | RCL1 |
| Transcriptional regulator that binds to the upstreamenhancer region (CCAC box) of myoglobin gene (By similarity).Important regulatory factor of the myogenic progenitor cellpopulation (By similarity). Involved in the cell cycle process,promotes proliferation by repressing Foxo4 transcriptionalactivity and the cyclin-dependent kinase inhibitor, p21CIP, in themyogenic progenitor cells (By similarity). Represses myogenicdifferentiation by inhibiting MEFC acitivity (By similarity). Hasa role in remodeling processes of adult muscles that occur inresponse to physiological stimuli (By similarity). Required tocorrect temporal orchestration of molecular and cellular eventsnecessary for muscle repair (By similarity). Positively regulatesWnt/beta-catenin signaling by translocating DVL into the nucleus(PubMed:25805136). Reduces virus replication, probably by bindingthe interferon stimulated response element (ISRE) to promoteantiviral gene expression (PubMed:25852164).{ECO:0000250|UniProtKB:P42128, ECO:0000269|PubMed:25805136,ECO:0000269|PubMed:25852164}. | Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processingsteps at sites A0, A1 and A2 that are required for propermaturation of the 18S RNA (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FOXK1_RCL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FOXK1_RCL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FOXK1_RCL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FOXK1_RCL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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