	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 13758

FusionGeneSummary for FOXJ3_FOXJ3

Fusion gene summary

Fusion gene information	Fusion gene name: FOXJ3_FOXJ3
	Fusion gene ID: 13758
		Hgene	Tgene
	Gene symbol	FOXJ3	FOXJ3
	Gene ID	22887	22887
	Gene name	forkhead box J3	forkhead box J3
	Synonyms	-	-
	Cytomap	1p34.2	1p34.2
	Type of gene	protein-coding	protein-coding
	Description	forkhead box protein J3	forkhead box protein J3
	Modification date	20180522	20180522
	UniProtAcc	Q9UPW0	Q9UPW0
	Ensembl transtripts involved in fusion gene	ENST00000372572, ENST00000372573, ENST00000361346, ENST00000361776, ENST00000545068, ENST00000372571,	ENST00000372572, ENST00000372573, ENST00000361346, ENST00000361776, ENST00000545068, ENST00000372571,
Fusion gene scores	* DoF score	14 X 9 X 11=1386	9 X 8 X 3=216
	# samples	16	8
	** MAII score	log2(16/1386*10)=-3.11478344724985 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/216*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: FOXJ3 [Title/Abstract] AND FOXJ3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FOXJ3	GO:0045944	positive regulation of transcription by RNA polymerase II	22740631
Tgene	FOXJ3	GO:0045944	positive regulation of transcription by RNA polymerase II	22740631

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF925020	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000372572	ENST00000372572	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372572	ENST00000372573	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372572	ENST00000361346	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372572	ENST00000361776	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372572	ENST00000545068	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372572	ENST00000372571	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372573	ENST00000372572	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372573	ENST00000372573	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372573	ENST00000361346	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372573	ENST00000361776	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372573	ENST00000545068	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372573	ENST00000372571	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361346	ENST00000372572	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361346	ENST00000372573	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361346	ENST00000361346	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361346	ENST00000361776	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361346	ENST00000545068	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361346	ENST00000372571	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361776	ENST00000372572	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361776	ENST00000372573	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361776	ENST00000361346	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361776	ENST00000361776	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361776	ENST00000545068	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000361776	ENST00000372571	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000545068	ENST00000372572	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000545068	ENST00000372573	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000545068	ENST00000361346	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000545068	ENST00000361776	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000545068	ENST00000545068	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000545068	ENST00000372571	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372571	ENST00000372572	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372571	ENST00000372573	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372571	ENST00000361346	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372571	ENST00000361776	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372571	ENST00000545068	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+
intron-intron	ENST00000372571	ENST00000372571	FOXJ3	chr1	42652343	-	FOXJ3	chr1	42652305	+

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FusionProtFeatures for FOXJ3_FOXJ3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FOXJ3 Q9UPW0	FOXJ3 Q9UPW0
Transcriptional activator of MEF2C involved in theregulation pf adult muscle fiber type identity and skeletal muscleregeneration. {ECO:0000250\|UniProtKB:Q8BUR3}.	Transcriptional activator of MEF2C involved in theregulation pf adult muscle fiber type identity and skeletal muscleregeneration. {ECO:0000250\|UniProtKB:Q8BUR3}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for FOXJ3_FOXJ3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FOXJ3_FOXJ3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for FOXJ3_FOXJ3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for FOXJ3_FOXJ3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 13758

FusionGeneSummary for FOXJ3_FOXJ3

FusionProtFeatures for FOXJ3_FOXJ3

FusionGeneSequence for FOXJ3_FOXJ3

FusionGenePPI for FOXJ3_FOXJ3

RelatedDrugs for FOXJ3_FOXJ3

RelatedDiseases for FOXJ3_FOXJ3