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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13756

FusionGeneSummary for FOXJ3_EIF4G3

check button Fusion gene summary
Fusion gene informationFusion gene name: FOXJ3_EIF4G3
Fusion gene ID: 13756
HgeneTgene
Gene symbol

FOXJ3

EIF4G3

Gene ID

22887

8672

Gene nameforkhead box J3eukaryotic translation initiation factor 4 gamma 3
Synonyms-eIF-4G 3|eIF4G 3|eIF4GII
Cytomap

1p34.2

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionforkhead box protein J3eukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma II
Modification date2018052220180523
UniProtAcc

Q9UPW0

O43432

Ensembl transtripts involved in fusion geneENST00000372572, ENST00000372573, 
ENST00000361346, ENST00000361776, 
ENST00000545068, ENST00000372571, 
ENST00000264211, ENST00000400422, 
ENST00000602326, ENST00000374935, 
ENST00000374937, ENST00000536266, 
ENST00000374933, ENST00000544689, 
ENST00000356916, ENST00000374927, 
ENST00000537738, 
Fusion gene scores* DoF score14 X 9 X 11=138613 X 14 X 7=1274
# samples 1614
** MAII scorelog2(16/1386*10)=-3.11478344724985
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/1274*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOXJ3 [Title/Abstract] AND EIF4G3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOXJ3

GO:0045944

positive regulation of transcription by RNA polymerase II

22740631


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-8058-01AFOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000372572ENST00000264211FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000372572ENST00000400422FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000372572ENST00000602326FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372572ENST00000374935FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372572ENST00000374937FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-5UTRENST00000372572ENST00000536266FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372572ENST00000374933FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372572ENST00000544689FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372572ENST00000356916FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372572ENST00000374927FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372572ENST00000537738FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-3CDSENST00000372573ENST00000264211FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-3CDSENST00000372573ENST00000400422FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-3CDSENST00000372573ENST00000602326FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-intronENST00000372573ENST00000374935FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-intronENST00000372573ENST00000374937FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-5UTRENST00000372573ENST00000536266FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-intronENST00000372573ENST00000374933FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-intronENST00000372573ENST00000544689FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-intronENST00000372573ENST00000356916FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-intronENST00000372573ENST00000374927FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
5UTR-intronENST00000372573ENST00000537738FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000361346ENST00000264211FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000361346ENST00000400422FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000361346ENST00000602326FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361346ENST00000374935FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361346ENST00000374937FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-5UTRENST00000361346ENST00000536266FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361346ENST00000374933FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361346ENST00000544689FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361346ENST00000356916FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361346ENST00000374927FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361346ENST00000537738FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000361776ENST00000264211FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000361776ENST00000400422FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000361776ENST00000602326FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361776ENST00000374935FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361776ENST00000374937FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-5UTRENST00000361776ENST00000536266FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361776ENST00000374933FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361776ENST00000544689FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361776ENST00000356916FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361776ENST00000374927FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000361776ENST00000537738FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000545068ENST00000264211FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000545068ENST00000400422FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000545068ENST00000602326FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000545068ENST00000374935FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000545068ENST00000374937FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-5UTRENST00000545068ENST00000536266FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000545068ENST00000374933FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000545068ENST00000544689FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000545068ENST00000356916FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000545068ENST00000374927FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000545068ENST00000537738FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000372571ENST00000264211FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000372571ENST00000400422FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-3CDSENST00000372571ENST00000602326FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372571ENST00000374935FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372571ENST00000374937FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-5UTRENST00000372571ENST00000536266FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372571ENST00000374933FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372571ENST00000544689FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372571ENST00000356916FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372571ENST00000374927FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-
intron-intronENST00000372571ENST00000537738FOXJ3chr1

42801297

-EIF4G3chr1

21268823

-

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FusionProtFeatures for FOXJ3_EIF4G3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOXJ3

Q9UPW0

EIF4G3

O43432

Transcriptional activator of MEF2C involved in theregulation pf adult muscle fiber type identity and skeletal muscleregeneration. {ECO:0000250|UniProtKB:Q8BUR3}. Probable component of the protein complex eIF4F, whichis involved in the recognition of the mRNA cap, ATP-dependentunwinding of 5'-terminal secondary structure and recruitment ofmRNA to the ribosome. Thought to be a functional homolog ofEIF4G1. {ECO:0000269|PubMed:9418880}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FOXJ3_EIF4G3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FOXJ3_EIF4G3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FOXJ3TERF1, TERF2, MED4, ELAVL1, DDX42, ALB, TP53, RANGAP1, SMARCA5, UBR2, ZBTB10, RPA2, USP11, FOXJ1, PSMB4, ZBTB2, TRIM25EIF4G3EIF4A2, EIF4A1, PABPC1, USP10, EIF3H, EIF3F, MKNK1, VAV2, SIRT7, EIF4G1, EIF4G2, ESR1, LIG4, TARDBP, LGR4, EIF4E, COMTD1, QPRT, BCAT1, PNKD, RBFOX2, KPTN, PSMC3, ALDH3A2, HSPB1, EIF2B5, PUS7, PABPC4, SF3A2, NTRK1, EIF3B, CTR9, FAM46A, WDYHV1, NFATC2IP, EPHA1, SIGLECL1, HAO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FOXJ3_EIF4G3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FOXJ3_EIF4G3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource