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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13747

FusionGeneSummary for FOS_SPTBN1

check button Fusion gene summary
Fusion gene informationFusion gene name: FOS_SPTBN1
Fusion gene ID: 13747
HgeneTgene
Gene symbol

FOS

SPTBN1

Gene ID

2353

6711

Gene nameFos proto-oncogene, AP-1 transcription factor subunitspectrin beta, non-erythrocytic 1
SynonymsAP-1|C-FOS|p55ELF|HEL102|SPTB2|betaSpII
Cytomap

14q24.3

2p16.2

Type of geneprotein-codingprotein-coding
Descriptionproto-oncogene c-FosFBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)FBJ murine osteosarcoma viral oncogene homologFos proto-oncogene, AP-1 trancription factor subunitG0/G1 switch regulatory protein 7activator protein 1cellular ospectrin beta chain, non-erythrocytic 1beta-G spectrinbeta-II spectrinbeta-fodrinbeta-spectrin 2beta-spectrin IIbeta-spectrin non-erythrocytic 1embryonic liver beta-fodrinepididymis luminal protein 102fodrin beta chainspectrin beta chain, brain
Modification date2018052320180522
UniProtAcc

P01100

Q01082

Ensembl transtripts involved in fusion geneENST00000303562, ENST00000554617, 
ENST00000556324, ENST00000535987, 
ENST00000555242, ENST00000555686, 
ENST00000555347, 
ENST00000356805, 
ENST00000333896, 
Fusion gene scores* DoF score4 X 7 X 1=2813 X 13 X 6=1014
# samples 715
** MAII scorelog2(7/28*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(15/1014*10)=-2.75702324650746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FOS [Title/Abstract] AND SPTBN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFOS

GO:0007179

transforming growth factor beta receptor signaling pathway

9732876

HgeneFOS

GO:0034614

cellular response to reactive oxygen species

17217916

HgeneFOS

GO:0045893

positive regulation of transcription, DNA-templated

9732876

HgeneFOS

GO:0045944

positive regulation of transcription by RNA polymerase II

10508860

HgeneFOS

GO:0060395

SMAD protein signal transduction

9732876


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI045531FOSchr14

75746437

+SPTBN1chr2

54891170

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000303562ENST00000356805FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000303562ENST00000333896FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000554617ENST00000356805FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000554617ENST00000333896FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000556324ENST00000356805FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000556324ENST00000333896FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000535987ENST00000356805FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000535987ENST00000333896FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000555242ENST00000356805FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000555242ENST00000333896FOSchr14

75746437

+SPTBN1chr2

54891170

+
5UTR-intronENST00000555686ENST00000356805FOSchr14

75746437

+SPTBN1chr2

54891170

+
5UTR-intronENST00000555686ENST00000333896FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000555347ENST00000356805FOSchr14

75746437

+SPTBN1chr2

54891170

+
intron-intronENST00000555347ENST00000333896FOSchr14

75746437

+SPTBN1chr2

54891170

+

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FusionProtFeatures for FOS_SPTBN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FOS

P01100

SPTBN1

Q01082

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor.In the heterodimer, FOS and JUN/AP-1 basic regions each seems tointeract with symmetrical DNA half sites. On TGF-beta activation,forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has acritical function in regulating the development of cells destinedto form and maintain the skeleton. It is thought to have animportant role in signal transduction, cell proliferation anddifferentiation. In growing cells, activates phospholipidsynthesis, possibly by activating CDS1 and PI4K2A. This activityrequires Tyr-dephosphorylation and association with theendoplasmic reticulum. {ECO:0000269|PubMed:16055710,ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363,ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}. Fodrin, which seems to be involved in secretion,interacts with calmodulin in a calcium-dependent manner and isthus candidate for the calcium-dependent movement of thecytoskeleton at the membrane.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FOS_SPTBN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FOS_SPTBN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FOS_SPTBN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFOSP01100DB08813NadroparinProto-oncogene c-Fossmall moleculeapproved|investigational
TgeneSPTBN1Q01082DB01373CalciumSpectrin beta chain, non-erythrocytic 1small moleculeapproved|nutraceutical

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RelatedDiseases for FOS_SPTBN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFOSC0036572Seizures4CTD_human
HgeneFOSC0038220Status Epilepticus4CTD_human
HgeneFOSC0038587Substance Withdrawal Syndrome3CTD_human
HgeneFOSC0236736Cocaine-Related Disorders3CTD_human
HgeneFOSC0020538Hypertensive disease2CTD_human
HgeneFOSC0003469Anxiety Disorders1CTD_human
HgeneFOSC0011570Mental Depression1PSYGENET
HgeneFOSC0011581Depressive disorder1PSYGENET
HgeneFOSC0014175Endometriosis1CTD_human
HgeneFOSC0014544Epilepsy1CTD_human
HgeneFOSC0016063Osteitis Fibrosa Disseminata1CTD_human
HgeneFOSC0018843Heat Stroke1CTD_human
HgeneFOSC0019080Hemorrhage1CTD_human
HgeneFOSC0020429Hyperalgesia1CTD_human
HgeneFOSC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFOSC0024121Lung Neoplasms1CTD_human
HgeneFOSC0027765nervous system disorder1CTD_human
HgeneFOSC0035126Reperfusion Injury1CTD_human
HgeneFOSC0040997Trigeminal Neuralgia1CTD_human
HgeneFOSC0041696Unipolar Depression1PSYGENET
HgeneFOSC0235032Neurotoxicity Syndromes1CTD_human
HgeneFOSC0236733Amphetamine-Related Disorders1CTD_human
HgeneFOSC0270458Severe major depression with psychotic features1PSYGENET
HgeneFOSC0424295Hyperactive behavior1CTD_human
HgeneFOSC0740392Infarction, Middle Cerebral Artery1CTD_human
HgeneFOSC0743072Depression, psychotic1PSYGENET
HgeneFOSC1269683Major Depressive Disorder1PSYGENET
HgeneFOSC1458155Mammary Neoplasms1CTD_human
HgeneFOSC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneFOSC2239176Liver carcinoma1CTD_human
HgeneFOSC3495559Juvenile arthritis1CTD_human
TgeneSPTBN1C0043094Weight Gain1CTD_human