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Fusion gene ID: 13743 |
FusionGeneSummary for FOSL2_SNX17 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FOSL2_SNX17 | Fusion gene ID: 13743 | Hgene | Tgene | Gene symbol | FOSL2 | SNX17 | Gene ID | 2355 | 9784 |
| Gene name | FOS like 2, AP-1 transcription factor subunit | sorting nexin 17 | |
| Synonyms | FRA2 | - | |
| Cytomap | 2p23.2 | 2p23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fos-related antigen 2FOS like 2, AP-1 trancription factor subunitFOS like antigen 2FRA-2 | sorting nexin-17 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P15408 | Q15036 | |
| Ensembl transtripts involved in fusion gene | ENST00000460736, ENST00000379619, ENST00000264716, ENST00000545753, | ENST00000233575, ENST00000543024, ENST00000537606, ENST00000542478, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: FOSL2 [Title/Abstract] AND SNX17 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FOSL2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 13679379 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-61-1738-01A | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000460736 | ENST00000233575 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-intron | ENST00000460736 | ENST00000543024 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-intron | ENST00000460736 | ENST00000537606 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-5UTR | ENST00000460736 | ENST00000542478 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-3CDS | ENST00000379619 | ENST00000233575 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-intron | ENST00000379619 | ENST00000543024 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-intron | ENST00000379619 | ENST00000537606 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-5UTR | ENST00000379619 | ENST00000542478 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| In-frame | ENST00000264716 | ENST00000233575 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| 5CDS-intron | ENST00000264716 | ENST00000543024 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| 5CDS-intron | ENST00000264716 | ENST00000537606 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| 5CDS-5UTR | ENST00000264716 | ENST00000542478 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-3CDS | ENST00000545753 | ENST00000233575 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-intron | ENST00000545753 | ENST00000543024 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-intron | ENST00000545753 | ENST00000537606 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
| intron-5UTR | ENST00000545753 | ENST00000542478 | FOSL2 | chr2 | 28616689 | + | SNX17 | chr2 | 27594136 | + |
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FusionProtFeatures for FOSL2_SNX17 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FOSL2 | SNX17 |
| Controls osteoclast survival and size. As a dimer withJUN, activates LIF transcription. Activates CEBPB transcription inPGE2-activated osteoblasts. {ECO:0000250}. | Critical regulator of endosomal recycling of numerousreceptors, channels, and other transmembrane proteins. Binds toNPxY sequences in the cytoplasmic tails of target cargos. Plays arole in the sorting of endocytosed LRP1 and APP, and preventstheir degradation. Required for maintenance of normal cell surfacelevels of APP and LRP1. Recycles internalized integrins ITGB1,ITGB5 and their associated alpha subunits, preventing them fromlysosomal degradation. Interacts with membranes containingphosphatidylinositol 3-phosphate (PtdIns(3P)).{ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472,ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208,ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FOSL2_SNX17 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FOSL2_ENST00000264716_chr2_28616689_+_SNX17_ENST00000233575_chr2_27594136_+_484aa MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRRE QLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVRE KEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKK EFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLE LAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FOSL2_ENST00000264716_chr2_28616689_+_SNX17_ENST00000233575_chr2_27594136_+_1452nt ATGTACCAGGATTATCCCGGGAACTTTGACACCTCGTCCCGGGGCAGCAGCGGCTCTCCTGCGCACGCCGAGTCCTACTCCAGCGGCGGC GGCGGCCAGCAGGCCTATAACATTCACGTGAATGGAGTCCTGCACTGTCGGGTGCGCTACAGCCAGCTCCTGGGGCTGCACGAGCAGCTT CGGAAGGAGTATGGGGCCAATGTGCTTCCTGCATTCCCCCCAAAGAAGCTTTTCTCTCTGACTCCTGCTGAGGTAGAACAGAGGAGAGAG CAGTTAGAGAAGTACATGCAAGCTGTTCGGCAAGACCCATTGCTTGGGAGCAGCGAGACTTTCAACAGTTTCCTGCGTCGGGCACAACAG GAGACACAGCAGGTCCCCACAGAGGAAGTGTCCTTGGAAGTGCTGCTCAGCAACGGGCAGAAAGTTCTGGTCAACGTGCTAACTTCAGAT CAGACTGAGGATGTCCTGGAGGCTGTAGCTGCAAAGCTGGATCTTCCAGATGACTTGATTGGATACTTTAGTCTATTCTTAGTTCGAGAA AAAGAGGATGGAGCCTTTTCTTTTGTACGGAAGTTGCAAGAGTTTGAGCTGCCTTATGTGTCTGTCACCAGCCTTCGGAGTCAAGAGTAT AAGATTGTGCTAAGGAAGAGTTATTGGGACTCTGCCTATGATGACGATGTCATGGAGAACCGGGTTGGCCTGAACCTGCTTTATGCTCAG ACGGTATCAGATATTGAGCGTGGGTGGATCTTGGTCACCAAGGAACAGCACCGGCAACTCAAATCTCTGCAAGAGAAAGTCTCCAAGAAG GAGTTCCTGAGACTGGCCCAGACGCTGCGGCACTATGGCTACTTGCGCTTTGATGCCTGTGTGGCTGACTTCCCAGAAAAGGACTGTCCT GTGGTGGTGAGCGCGGGCAACAGTGAGCTCAGCCTGCAGCTCCGCCTGCCTGGCCAGCAACTCCGAGAAGGCTCCTTCCGGGTCACCCGC ATGCGATGCTGGCGGGTCACCTCCTCTGTACCATTGCCCAGTGGAAGCACGAGCAGCCCAGGCCGGGGCCGGGGTGAGGTGCGCCTGGAA CTGGCTTTTGAATACCTCATGAGCAAGGACCGGCTACAGTGGGTCACCATCACTAGCCCCCAGGCTATCATGATGAGCATCTGCTTGCAG TCCATGGTTGATGAACTGATGGTGAAGAAATCTGGCGGCAGTATCAGGAAGATGCTGCGCCGGCGGGTGGGGGGTACTCTGAGACGCTCA GACAGCCAGCAAGCAGTGAAGTCCCCACCACTGCTTGAGTCACCTGATGCCACCCGGGAGTCTATGGTCAAACTCTCAAGTAAGCTGAGT GCCGTGAGCTTGCGGGGAATTGGCAGTCCCAGCACAGATGCCAGTGCCAGTGATGTCCACGGCAATTTCGCCTTCGAGGGCATTGGAGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FOSL2_ENST00000264716_chr2_28616689_+_SNX17_ENST00000233575_chr2_27594136_+_2724nt GTAGTGACTCATCTCGGGCAGAGCGCTAGGGCTCCGAGCGAACCAGCGAGCGAGCGAACGAGCGGCGCTCGGCGGGGACAGAAAGAGGGA GAGAGAGAGAGAGAGAGAGGGAGAGGCGCGGCCGGGCGAGGCGGGCCCGTCCGGGAGCGGGCTCCGGGGAAGGGGTGCGGGTCTGGGCGC CGGAGCGGGGAGCGGGGCCGCGTCCCTCTCAGCGCCAGCTCTACTTGAGCCCCACGAGCCGCTGTCCCCCTGGCGCGCTCGGGGCCGCGG GACGGGCGCACGCCGCCTTCTCCTAGTCAAGTATCCGAGCCGCCCCGAAACTCGGGCGGCGAGTCGGCCACGGGAAGTTTATTCTCCGGC TCCTTTTCTAAAAGGAAGAAACAGAAGTTTCTCCCAGCGGACAGCTTTTCTTTCCGCCTTTTTGGCCCTGTCTGAAATCGGGGGTCCCCA GGGCTGGCAGGCCAGGCTCGCTGGGCTCCTAATCTTTTTTTTAATTTCCAATTTTTGATTGGGCCGTGGGTCCCCGCTGAGCTCCGGCTG CGCGCGGGGGCGGGAGGGCGCGCGCAGGGGAGGGACCGAGAGACGCGCCGACTTTTTAGAGGGAGGGATCGGGTGGACAACTGGTCCCGC GGCGCTCGCAGAGCCGGAAAGAAGTGCTGTAAGGGACGCTCGGGGGACGCTGTTCCTGAGGTGTCGCCGCCTCCCTGTCCTCGCCCTCCG CGGTGGGGGAGAAACCCAGGAGCGAAGCCCAGAGCCCGCGGCGCGGCCGGCGGACGAACGAGCGCGCAGCAGCCGGTGCGCGGCCGCGGC GAGGGCGGGGGAAGAAAAACACCCTGTTTCCTCTCCGGCCCCCACCGCGGATCATGTACCAGGATTATCCCGGGAACTTTGACACCTCGT CCCGGGGCAGCAGCGGCTCTCCTGCGCACGCCGAGTCCTACTCCAGCGGCGGCGGCGGCCAGCAGGCCTATAACATTCACGTGAATGGAG TCCTGCACTGTCGGGTGCGCTACAGCCAGCTCCTGGGGCTGCACGAGCAGCTTCGGAAGGAGTATGGGGCCAATGTGCTTCCTGCATTCC CCCCAAAGAAGCTTTTCTCTCTGACTCCTGCTGAGGTAGAACAGAGGAGAGAGCAGTTAGAGAAGTACATGCAAGCTGTTCGGCAAGACC CATTGCTTGGGAGCAGCGAGACTTTCAACAGTTTCCTGCGTCGGGCACAACAGGAGACACAGCAGGTCCCCACAGAGGAAGTGTCCTTGG AAGTGCTGCTCAGCAACGGGCAGAAAGTTCTGGTCAACGTGCTAACTTCAGATCAGACTGAGGATGTCCTGGAGGCTGTAGCTGCAAAGC TGGATCTTCCAGATGACTTGATTGGATACTTTAGTCTATTCTTAGTTCGAGAAAAAGAGGATGGAGCCTTTTCTTTTGTACGGAAGTTGC AAGAGTTTGAGCTGCCTTATGTGTCTGTCACCAGCCTTCGGAGTCAAGAGTATAAGATTGTGCTAAGGAAGAGTTATTGGGACTCTGCCT ATGATGACGATGTCATGGAGAACCGGGTTGGCCTGAACCTGCTTTATGCTCAGACGGTATCAGATATTGAGCGTGGGTGGATCTTGGTCA CCAAGGAACAGCACCGGCAACTCAAATCTCTGCAAGAGAAAGTCTCCAAGAAGGAGTTCCTGAGACTGGCCCAGACGCTGCGGCACTATG GCTACTTGCGCTTTGATGCCTGTGTGGCTGACTTCCCAGAAAAGGACTGTCCTGTGGTGGTGAGCGCGGGCAACAGTGAGCTCAGCCTGC AGCTCCGCCTGCCTGGCCAGCAACTCCGAGAAGGCTCCTTCCGGGTCACCCGCATGCGATGCTGGCGGGTCACCTCCTCTGTACCATTGC CCAGTGGAAGCACGAGCAGCCCAGGCCGGGGCCGGGGTGAGGTGCGCCTGGAACTGGCTTTTGAATACCTCATGAGCAAGGACCGGCTAC AGTGGGTCACCATCACTAGCCCCCAGGCTATCATGATGAGCATCTGCTTGCAGTCCATGGTTGATGAACTGATGGTGAAGAAATCTGGCG GCAGTATCAGGAAGATGCTGCGCCGGCGGGTGGGGGGTACTCTGAGACGCTCAGACAGCCAGCAAGCAGTGAAGTCCCCACCACTGCTTG AGTCACCTGATGCCACCCGGGAGTCTATGGTCAAACTCTCAAGTAAGCTGAGTGCCGTGAGCTTGCGGGGAATTGGCAGTCCCAGCACAG ATGCCAGTGCCAGTGATGTCCACGGCAATTTCGCCTTCGAGGGCATTGGAGATGAGGATCTGTAATCTCCACTGCTTGGATGTCTGCCCT CTACCCCAGAGGAATTTACAGAAACTTGCCCTGTGCCTGTGTCCCCCATGCTAGGGGCGGAGGGGTCTTTTCCTTCTTCTTTCCTACCTA CCCCTTTTCTCTTGGCCAGGGGCCTCGTATCCTACCTTTCCTTGTCCCCTGGGCTGGCTGCACAGAGGATTGCCCCTTCTCTTTTCAGAG CTGGCCCTCGATGCCAAATTAGCATTTAGTATTTTGCACAAAGTCTAAGGGACCATGGCTGCCTGCCTTGGGGAGGAACCATATCTCCCT CTGGGCCGCTTCTGGCCTCTTGGAGCCATGGGCCAAAGGCCAAGGGGATGGGCAGAGGTCTGTGTTTGGTCTGGCCCAGTTCCCCATCAT |
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FusionGenePPI for FOSL2_SNX17 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FOSL2 | JUN, EP300, ATF1, SRA1, JUNB, DDIT3, FHL3, TRAF1, DNAJA3, CREB5, LUZP4, GOPC, GMCL1, BRCA1, ATF2, ATF7, JUND, SORL1, ZZEF1, CARM1, CALCOCO1, VARS, HECTD3, ANKHD1, ANKRD17, IRF2BP2, CYTH2, CYTH3, RFWD2, KBTBD7, KBTBD6, TSR3, NBEA, EEF1D, FBXO11, BACH2, YEATS4, STK40, RUFY1, IRF2BP1, DET1, PRMT6, TRIB1, IRF2BPL, EGR1, STMN1, RPL21, RPL30, SPAST, RPL14, RECQL5, MED16, METTL17, DPY30, LSM11, DNMT3L, USF2, BAHCC1 | SNX17 | SELP, LDLR, LRP1, VLDLR, LRP2, LRP8, SKIL, RLIM, MOV10, NXF1, INSR, NTRK1, HRAS, APP, TSPAN3, FRMD6, NPDC1, GMPR2, C1orf186, CEP170, XPO1, FOXO1, MTM1, DUSP1, VIPR2, MANSC1, IL20RA, SLC1A1, HAVCR2, TPCN2, NCR3LG1, GPRC5C, MRAP2, DAB2IP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FOSL2_SNX17 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FOSL2_SNX17 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FOSL2 | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | FOSL2 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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