FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13722

FusionGeneSummary for FNTB_RAB15

check button Fusion gene summary
Fusion gene informationFusion gene name: FNTB_RAB15
Fusion gene ID: 13722
HgeneTgene
Gene symbol

FNTB

RAB15

Gene ID

2342

376267

Gene namefarnesyltransferase, CAAX box, betaRAB15, member RAS oncogene family
SynonymsFPTB-
Cytomap

14q23.3

14q23.3

Type of geneprotein-codingprotein-coding
Descriptionprotein farnesyltransferase subunit betaCAAX farnesyltransferase subunit betaFTase-betaras proteins prenyltransferase subunit betaras-related protein Rab-15RAB15, member RAS onocogene familyRas-related protein Rab-15 isoform AN1Ras-related protein Rab-15 isoform AN2Ras-related protein Rab-15 isoform AN3
Modification date2018052320180523
UniProtAcc

P49356

P59190

Ensembl transtripts involved in fusion geneENST00000542227, ENST00000447296, 
ENST00000246166, ENST00000555742, 
ENST00000267512, ENST00000533601, 
ENST00000436278, ENST00000426039, 
Fusion gene scores* DoF score3 X 2 X 2=122 X 2 X 2=8
# samples 32
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: FNTB [Title/Abstract] AND RAB15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFNTB

GO:0018343

protein farnesylation

16893176|19228685


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A09R-01AFNTBchr14

65453815

+RAB15chr14

65419289

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000542227ENST00000267512FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-3CDSENST00000542227ENST00000533601FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-5UTRENST00000542227ENST00000436278FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-5UTRENST00000542227ENST00000426039FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-3CDSENST00000447296ENST00000267512FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-3CDSENST00000447296ENST00000533601FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-5UTRENST00000447296ENST00000436278FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-5UTRENST00000447296ENST00000426039FNTBchr14

65453815

+RAB15chr14

65419289

-
Frame-shiftENST00000246166ENST00000267512FNTBchr14

65453815

+RAB15chr14

65419289

-
Frame-shiftENST00000246166ENST00000533601FNTBchr14

65453815

+RAB15chr14

65419289

-
5CDS-5UTRENST00000246166ENST00000436278FNTBchr14

65453815

+RAB15chr14

65419289

-
5CDS-5UTRENST00000246166ENST00000426039FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-3CDSENST00000555742ENST00000267512FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-3CDSENST00000555742ENST00000533601FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-5UTRENST00000555742ENST00000436278FNTBchr14

65453815

+RAB15chr14

65419289

-
intron-5UTRENST00000555742ENST00000426039FNTBchr14

65453815

+RAB15chr14

65419289

-

Top

FusionProtFeatures for FNTB_RAB15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNTB

P49356

RAB15

P59190

Essential subunit of the farnesyltransferase complex.Catalyzes the transfer of a farnesyl moiety from farnesyldiphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. {ECO:0000269|PubMed:12036349,ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176,ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8494894}. May act in concert with RAB3A in regulating aspects ofsynaptic vesicle membrane flow within the nerve terminal.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FNTB_RAB15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FNTB_RAB15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FNTBPTP4A2, HDAC6, DYRK1A, UGGT1, NPLOC4, RPRD1A, AUP1, FAM53C, NAP1L1, UBB, SPDL1, YKT6, HOOK3, LMNB2, CENPF, FNTA, CAPN1, GRIP1, DHX57, ENPP1, CAST, RRAS2, UHRF1BP1L, PITHD1, PPM1B, NDUFAF7, CAPNS1, PTP4A1, FAM117B, SMPD2, HOOK2, TROAP, GLYR1, RPL18, ARFGAP1, AVP, TP53TG5, PRPSAP2, MRPS11, LBHD1, AURKAIP1, INTU, C10orf71, FAM131B, CAPN8, CPA6, KCNS3, DCAF7, ARNT2RAB15RABIF, CDK2, UBL4A, RAP1GDS1, TOR1AIP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FNTB_RAB15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FNTB_RAB15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource