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Fusion gene ID: 13717 |
FusionGeneSummary for FNTA_OVOL1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: FNTA_OVOL1 | Fusion gene ID: 13717 | Hgene | Tgene | Gene symbol | FNTA | OVOL1 | Gene ID | 2339 | 5017 |
Gene name | farnesyltransferase, CAAX box, alpha | ovo like transcriptional repressor 1 | |
Synonyms | FPTA|PGGT1A|PTAR2 | HOVO1 | |
Cytomap | 8p11.21 | 11q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaFTase-alphaGGTase-I-alphafarnesyl-protein transferase alpha-subunitprotein prenyltransferase alpha subunit repeat containing 2ras proteins prenyltransferase subunit alphatype | putative transcription factor Ovo-like 1ovo homolog-like 1ovo like zinc finger 1ovo-like 1(Drosophila) | |
Modification date | 20180523 | 20180520 | |
UniProtAcc | P49354 | O14753 | |
Ensembl transtripts involved in fusion gene | ENST00000302279, ENST00000342116, ENST00000524546, ENST00000529687, | ENST00000335987, ENST00000531907, ENST00000532448, | |
Fusion gene scores | * DoF score | 5 X 7 X 3=105 | 1 X 1 X 1=1 |
# samples | 9 | 1 | |
** MAII score | log2(9/105*10)=-0.222392421336448 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: FNTA [Title/Abstract] AND OVOL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FNTA | GO:0018343 | protein farnesylation | 16893176|19228685 |
Hgene | FNTA | GO:0018344 | protein geranylgeranylation | 16893176 |
Hgene | FNTA | GO:0090044 | positive regulation of tubulin deacetylation | 19228685 |
Hgene | FNTA | GO:0090045 | positive regulation of deacetylase activity | 19228685 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A7-A3IZ-01A | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000302279 | ENST00000335987 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
5CDS-3UTR | ENST00000302279 | ENST00000531907 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
5CDS-5UTR | ENST00000302279 | ENST00000532448 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
Frame-shift | ENST00000342116 | ENST00000335987 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
5CDS-3UTR | ENST00000342116 | ENST00000531907 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
5CDS-5UTR | ENST00000342116 | ENST00000532448 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
3UTR-3CDS | ENST00000524546 | ENST00000335987 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
3UTR-3UTR | ENST00000524546 | ENST00000531907 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
3UTR-5UTR | ENST00000524546 | ENST00000532448 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
intron-3CDS | ENST00000529687 | ENST00000335987 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
intron-3UTR | ENST00000529687 | ENST00000531907 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
intron-5UTR | ENST00000529687 | ENST00000532448 | FNTA | chr8 | 42911689 | + | OVOL1 | chr11 | 65561502 | + |
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FusionProtFeatures for FNTA_OVOL1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FNTA | OVOL1 |
Essential subunit of both the farnesyltransferase andthe geranylgeranyltransferase complex. Contributes to the transferof a farnesyl or geranylgeranyl moiety from farnesyl orgeranylgeranyl diphosphate to a cysteine at the fourth positionfrom the C-terminus of several proteins having the C-terminalsequence Cys-aliphatic-aliphatic-X. May positively regulateneuromuscular junction development downstream of MUSK via itsfunction in RAC1 prenylation and activation.{ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937,ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009,ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}. | Putative transcription factor. Involved in hairformation and spermatogenesis. May function in the differentiationand/or maintenance of the urogenital system (By similarity).{ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FNTA_OVOL1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FNTA_OVOL1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FNTA | ACVR1, TGFB1, PTP4A2, TGFBR1, HDAC6, VAV2, TGM2, INHBB, STAT2, SAFB2, RPL13A, DYRK1A, HK2, AMMECR1L, HEYL, NAP1L1, FNTB, DARS2, TOP1, BRCA1, BRAF, FGFR3, KDM6A, CAPN1, ARFGAP1, TSKS, RPL18, C10orf71, EPB41L5, FAM117B, ARNT2, XRCC3, ATAD5, BLM, MTOR, RPS19 | OVOL1 | HDAC1, HDAC2, HDAC3, MAFF, SUFU |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FNTA_OVOL1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FNTA_OVOL1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | OVOL1 | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
Tgene | OVOL1 | C0206711 | Pilomatrixoma | 1 | CTD_human |