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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13711

FusionGeneSummary for FNIP2_LRAT

check button Fusion gene summary
Fusion gene informationFusion gene name: FNIP2_LRAT
Fusion gene ID: 13711
HgeneTgene
Gene symbol

FNIP2

LRAT

Gene ID

57600

9227

Gene namefolliculin interacting protein 2lecithin retinol acyltransferase
SynonymsFNIPL|MAPO1LCA14
Cytomap

4q32.1

4q32.1

Type of geneprotein-codingprotein-coding
Descriptionfolliculin-interacting protein 2FNIP1-like proteinO6-methylguanine-induced apoptosis 1 proteinlecithin retinol acyltransferaselecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Modification date2018051920180519
UniProtAcc

Q9P278

O95237

Ensembl transtripts involved in fusion geneENST00000264433, ENST00000379346, 
ENST00000505445, 
ENST00000500890, 
ENST00000507827, ENST00000336356, 
Fusion gene scores* DoF score9 X 5 X 6=2703 X 2 X 3=18
# samples 93
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FNIP2 [Title/Abstract] AND LRAT [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFNIP2

GO:0000122

negative regulation of transcription by RNA polymerase II

21209915

HgeneFNIP2

GO:0001932

regulation of protein phosphorylation

18663353

HgeneFNIP2

GO:0006468

protein phosphorylation

18663353

HgeneFNIP2

GO:0031334

positive regulation of protein complex assembly

25126726

HgeneFNIP2

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19914239

TgeneLRAT

GO:0042572

retinol metabolic process

10819989


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-YJ-A8SW-01AFNIP2chr4

159690471

+LRATchr4

155649855

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264433ENST00000500890FNIP2chr4

159690471

+LRATchr4

155649855

+
5CDS-intronENST00000264433ENST00000507827FNIP2chr4

159690471

+LRATchr4

155649855

+
5CDS-intronENST00000264433ENST00000336356FNIP2chr4

159690471

+LRATchr4

155649855

+
intron-intronENST00000379346ENST00000500890FNIP2chr4

159690471

+LRATchr4

155649855

+
intron-intronENST00000379346ENST00000507827FNIP2chr4

159690471

+LRATchr4

155649855

+
intron-intronENST00000379346ENST00000336356FNIP2chr4

159690471

+LRATchr4

155649855

+
intron-intronENST00000505445ENST00000500890FNIP2chr4

159690471

+LRATchr4

155649855

+
intron-intronENST00000505445ENST00000507827FNIP2chr4

159690471

+LRATchr4

155649855

+
intron-intronENST00000505445ENST00000336356FNIP2chr4

159690471

+LRATchr4

155649855

+

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FusionProtFeatures for FNIP2_LRAT


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNIP2

Q9P278

LRAT

O95237

Acts as a co-chaperone of HSP90AA1. Inhibits the ATPaseactivity of HSP90AA1 leading to reduction in its chaperoneactivity. Facilitates the binding of client protein FLCN toHSP90AA1 (PubMed:27353360). May play a role in the signaltransduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energyand/or nutrient sensing through the AMPK and mTOR signalingpathways (PubMed:18403135). May regulate phosphorylation ofRPS6KB1 (PubMed:18663353). {ECO:0000250|UniProtKB:Q80TD3,ECO:0000269|PubMed:18403135, ECO:0000269|PubMed:18663353,ECO:0000269|PubMed:27353360}. Transfers the acyl group from the sn-1 position ofphosphatidylcholine to all-trans retinol, producing all-transretinyl esters. Retinyl esters are storage forms of vitamin A.LRAT plays a critical role in vision. It provides the all-transretinyl ester substrates for the isomerohydrolase which processesthe esters into 11-cis-retinol in the retinal pigment epithelium;due to a membrane-associated alcohol dehydrogenase, 11 cis-retinolis oxidized and converted into 11-cis-retinaldehyde which is thechromophore for rhodopsin and the cone photopigments.{ECO:0000269|PubMed:9920938}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FNIP2_LRAT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FNIP2_LRAT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FNIP2FLCN, GABARAP, HSP90AA1, HSPA1B, STIP1, CDC37, PTGES3, NR3C1, CDK4, BRAF, FNIP2, FNIP1LRATLRAT, NME2P1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FNIP2_LRAT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLRATO95237DB00162Vitamin ALecithin retinol acyltransferasesmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for FNIP2_LRAT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLRATC0917796Optic Atrophy, Hereditary, Leber2CTD_human
TgeneLRATC0015398Eye Diseases, Hereditary1CTD_human
TgeneLRATC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneLRATC0042842Vitamin A Deficiency1CTD_human
TgeneLRATC0339527Leber Congenital Amaurosis1CTD_human;ORPHANET
TgeneLRATC2750063Leber Congenital Amaurosis 141CTD_human;UNIPROT
TgeneLRATC4277682Chemical and Drug Induced Liver Injury1CTD_human