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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1370

FusionGeneSummary for AKAP9_ZNF3

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP9_ZNF3
Fusion gene ID: 1370
HgeneTgene
Gene symbol

AKAP9

ZNF3

Gene ID

10142

7551

Gene nameA-kinase anchoring protein 9zinc finger protein 3
SynonymsAKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAOA8-51|HF.12|KOX25|PP838|Zfp113
Cytomap

7q21.2

7q22.1

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associzinc finger protein 3C2-H2 type zinc finger proteinzinc finger protein HF.12zinc finger protein HZF3.1zinc finger protein KOX25
Modification date2018052320180523
UniProtAcc

Q99996

P17036

Ensembl transtripts involved in fusion geneENST00000356239, ENST00000358100, 
ENST00000359028, ENST00000394564, 
ENST00000491695, 		ENST00000413658, 
ENST00000424697, ENST00000303915, 
ENST00000299667, 
Fusion gene scores* DoF score12 X 12 X 7=10083 X 2 X 3=18
# samples 223
** MAII scorelog2(22/1008*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AKAP9 [Title/Abstract] AND ZNF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-B9-4116-01AAKAP9chr7

91570461

+ZNF3chr7

99675056

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000356239ENST00000413658AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000356239ENST00000424697AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000356239ENST00000303915AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000356239ENST00000299667AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000358100ENST00000413658AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000358100ENST00000424697AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000358100ENST00000303915AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000358100ENST00000299667AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000359028ENST00000413658AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000359028ENST00000424697AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000359028ENST00000303915AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000359028ENST00000299667AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000394564ENST00000413658AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000394564ENST00000424697AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000394564ENST00000303915AKAP9chr7

91570461

+ZNF3chr7

99675056

-
5CDS-5UTRENST00000394564ENST00000299667AKAP9chr7

91570461

+ZNF3chr7

99675056

-
intron-5UTRENST00000491695ENST00000413658AKAP9chr7

91570461

+ZNF3chr7

99675056

-
intron-5UTRENST00000491695ENST00000424697AKAP9chr7

91570461

+ZNF3chr7

99675056

-
intron-5UTRENST00000491695ENST00000303915AKAP9chr7

91570461

+ZNF3chr7

99675056

-
intron-5UTRENST00000491695ENST00000299667AKAP9chr7

91570461

+ZNF3chr7

99675056

-

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FusionProtFeatures for AKAP9_ZNF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP9

Q99996

ZNF3

P17036

Involved in cell differentiation and/or proliferation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AKAP9_ZNF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AKAP9_ZNF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AKAP9TACC3, FNBP1, TRIP10, PRKAR2A, KCNQ1, CLIC1, CALM2, CALM1, TUBGCP3, PKN1, CSNK1D, PMS1, CDC5L, DISC1, TNIK, CEBPA, CCNE1, TSG101, CDK5RAP2, KDM1A, TDP2, PCNT, GSK3A, RASSF2, SUV39H2, PRKACA, PRKACB, MAGEA6, HNRNPM, SSX2, BLZF1, USO1, MAGED1, IKZF3, WAC, THAP1, PRDM14, USHBP1, C1orf94, SAMD3, SUZ12, RNF2, BMI1, ROPN1L, MAPRE1, CEP170, CCDC68, PRKAR2B, HERC2, GPC4, DYNLL1, HUWE1, FGFR1OP, THOC2, CEP170P1, PCGF1, NANOG, ATOH1, TPTE2, PDE4DIP, PRKACG, C1orf87, DNAJC10, BIRC6, TPM2, HEY1ZNF3ZNF212, FHL2, ID3, ZNF3, BAG3, TRAF4, MTUS2, SSX2IP, SHCBP1, KBTBD7, PTPRK, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AKAP9_ZNF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AKAP9_ZNF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP9C0037274Dermatologic disorders1CTD_human
HgeneAKAP9C0311375Arsenic Poisoning1CTD_human
HgeneAKAP9C2678483Long Qt Syndrome 111CTD_human;UNIPROT