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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13682

FusionGeneSummary for FNDC3B_FNDC3B

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3B_FNDC3B
Fusion gene ID: 13682
HgeneTgene
Gene symbol

FNDC3B

FNDC3B

Gene ID

64778

64778

Gene namefibronectin type III domain containing 3Bfibronectin type III domain containing 3B
SynonymsFAD104|PRO4979|YVTM2421FAD104|PRO4979|YVTM2421
Cytomap

3q26.31

3q26.31

Type of geneprotein-codingprotein-coding
Descriptionfibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104fibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104
Modification date2018051920180519
UniProtAcc

Q53EP0

Q53EP0

Ensembl transtripts involved in fusion geneENST00000415807, ENST00000336824, 
ENST00000416957, ENST00000392699, 
ENST00000421757, ENST00000423424, 
ENST00000476794, 		ENST00000415807, 
ENST00000336824, ENST00000416957, 
ENST00000392699, ENST00000421757, 
ENST00000423424, ENST00000476794, 
Fusion gene scores* DoF score22 X 10 X 13=286011 X 13 X 5=715
# samples 2414
** MAII scorelog2(24/2860*10)=-3.57490883605723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/715*10)=-2.35251641472079
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FNDC3B [Title/Abstract] AND FNDC3B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE082950FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
ChiTaRS3.1CV351051FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
ChiTaRS3.1CV339967FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
ChiTaRS3.1BE548868FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000415807ENST00000415807FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000415807ENST00000336824FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000415807ENST00000416957FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000415807ENST00000392699FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000415807ENST00000421757FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000415807ENST00000423424FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000415807ENST00000476794FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000336824ENST00000415807FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000336824ENST00000336824FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000336824ENST00000416957FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000336824ENST00000392699FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000336824ENST00000421757FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000336824ENST00000423424FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000336824ENST00000476794FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000416957ENST00000415807FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000416957ENST00000336824FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000416957ENST00000416957FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000416957ENST00000392699FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000416957ENST00000421757FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000416957ENST00000423424FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000416957ENST00000476794FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000392699ENST00000415807FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000392699ENST00000336824FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000392699ENST00000416957FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000392699ENST00000392699FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000392699ENST00000421757FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000392699ENST00000423424FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000392699ENST00000476794FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000421757ENST00000415807FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000421757ENST00000336824FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000421757ENST00000416957FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000421757ENST00000392699FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000421757ENST00000421757FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000421757ENST00000423424FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000421757ENST00000476794FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000423424ENST00000415807FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000423424ENST00000336824FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000423424ENST00000416957FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000423424ENST00000392699FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000423424ENST00000421757FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000423424ENST00000423424FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000423424ENST00000476794FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000476794ENST00000415807FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000476794ENST00000336824FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000476794ENST00000416957FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000476794ENST00000392699FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000476794ENST00000421757FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000476794ENST00000423424FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000476794ENST00000476794FNDC3Bchr3

171965321

-FNDC3Bchr3

171969333

-
intron-intronENST00000415807ENST00000415807FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000415807ENST00000336824FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000415807ENST00000416957FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000415807ENST00000392699FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000415807ENST00000421757FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000415807ENST00000423424FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000415807ENST00000476794FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000336824ENST00000415807FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000336824ENST00000336824FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000336824ENST00000416957FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000336824ENST00000392699FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000336824ENST00000421757FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000336824ENST00000423424FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000336824ENST00000476794FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000416957ENST00000415807FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000416957ENST00000336824FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000416957ENST00000416957FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000416957ENST00000392699FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000416957ENST00000421757FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000416957ENST00000423424FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000416957ENST00000476794FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000392699ENST00000415807FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000392699ENST00000336824FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000392699ENST00000416957FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000392699ENST00000392699FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000392699ENST00000421757FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000392699ENST00000423424FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000392699ENST00000476794FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000421757ENST00000415807FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000421757ENST00000336824FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000421757ENST00000416957FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000421757ENST00000392699FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000421757ENST00000421757FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000421757ENST00000423424FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000421757ENST00000476794FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000423424ENST00000415807FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000423424ENST00000336824FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000423424ENST00000416957FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000423424ENST00000392699FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000423424ENST00000421757FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000423424ENST00000423424FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000423424ENST00000476794FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000476794ENST00000415807FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000476794ENST00000336824FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000476794ENST00000416957FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000476794ENST00000392699FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000476794ENST00000421757FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000476794ENST00000423424FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000476794ENST00000476794FNDC3Bchr3

171920935

+FNDC3Bchr3

171921023

-
intron-intronENST00000415807ENST00000415807FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-3UTRENST00000415807ENST00000336824FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000415807ENST00000416957FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000415807ENST00000392699FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000415807ENST00000421757FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000415807ENST00000423424FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000415807ENST00000476794FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
3UTR-intronENST00000336824ENST00000415807FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
3UTR-3UTRENST00000336824ENST00000336824FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
3UTR-intronENST00000336824ENST00000416957FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
3UTR-intronENST00000336824ENST00000392699FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
3UTR-intronENST00000336824ENST00000421757FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
3UTR-intronENST00000336824ENST00000423424FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
3UTR-intronENST00000336824ENST00000476794FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000416957ENST00000415807FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-3UTRENST00000416957ENST00000336824FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000416957ENST00000416957FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000416957ENST00000392699FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000416957ENST00000421757FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000416957ENST00000423424FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000416957ENST00000476794FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000392699ENST00000415807FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-3UTRENST00000392699ENST00000336824FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000392699ENST00000416957FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000392699ENST00000392699FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000392699ENST00000421757FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000392699ENST00000423424FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000392699ENST00000476794FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000421757ENST00000415807FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-3UTRENST00000421757ENST00000336824FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000421757ENST00000416957FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000421757ENST00000392699FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000421757ENST00000421757FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000421757ENST00000423424FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000421757ENST00000476794FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000423424ENST00000415807FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-3UTRENST00000423424ENST00000336824FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000423424ENST00000416957FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000423424ENST00000392699FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000423424ENST00000421757FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000423424ENST00000423424FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000423424ENST00000476794FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000476794ENST00000415807FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-3UTRENST00000476794ENST00000336824FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000476794ENST00000416957FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000476794ENST00000392699FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000476794ENST00000421757FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000476794ENST00000423424FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+
intron-intronENST00000476794ENST00000476794FNDC3Bchr3

172116853

-FNDC3Bchr3

172116887

+

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FusionProtFeatures for FNDC3B_FNDC3B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNDC3B

Q53EP0

FNDC3B

Q53EP0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FNDC3B_FNDC3B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FNDC3B_FNDC3B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FNDC3B_FNDC3B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FNDC3B_FNDC3B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFNDC3BC0022578Keratoconus1CTD_human
HgeneFNDC3BC0339573Glaucoma, Primary Open Angle1CTD_human
TgeneFNDC3BC0022578Keratoconus1CTD_human
TgeneFNDC3BC0339573Glaucoma, Primary Open Angle1CTD_human