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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 13680

FusionGeneSummary for FNDC3B_EMP3

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3B_EMP3
Fusion gene ID: 13680
HgeneTgene
Gene symbol

FNDC3B

EMP3

Gene ID

64778

2014

Gene namefibronectin type III domain containing 3Bepithelial membrane protein 3
SynonymsFAD104|PRO4979|YVTM2421YMP
Cytomap

3q26.31

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionfibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104epithelial membrane protein 3EMP-3HNMP-1hematopoietic neural membrane protein 1
Modification date2018051920180523
UniProtAcc

Q53EP0

P54852

Ensembl transtripts involved in fusion geneENST00000415807, ENST00000336824, 
ENST00000416957, ENST00000392699, 
ENST00000421757, ENST00000423424, 
ENST00000476794, 		ENST00000270221, 
ENST00000596315, ENST00000597279, 
Fusion gene scores* DoF score22 X 10 X 13=28602 X 3 X 2=12
# samples 242
** MAII scorelog2(24/2860*10)=-3.57490883605723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FNDC3B [Title/Abstract] AND EMP3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEMP3

GO:0008219

cell death

12107182

TgeneEMP3

GO:0032060

bleb assembly

12107182


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A5BT-01AFNDC3Bchr3

171969331

+EMP3chr19

48832609

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000415807ENST00000270221FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
5CDS-5UTRENST00000415807ENST00000596315FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
5CDS-5UTRENST00000415807ENST00000597279FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
In-frameENST00000336824ENST00000270221FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
5CDS-5UTRENST00000336824ENST00000596315FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
5CDS-5UTRENST00000336824ENST00000597279FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
In-frameENST00000416957ENST00000270221FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
5CDS-5UTRENST00000416957ENST00000596315FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
5CDS-5UTRENST00000416957ENST00000597279FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-3CDSENST00000392699ENST00000270221FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-5UTRENST00000392699ENST00000596315FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-5UTRENST00000392699ENST00000597279FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-3CDSENST00000421757ENST00000270221FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-5UTRENST00000421757ENST00000596315FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-5UTRENST00000421757ENST00000597279FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-3CDSENST00000423424ENST00000270221FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-5UTRENST00000423424ENST00000596315FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-5UTRENST00000423424ENST00000597279FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-3CDSENST00000476794ENST00000270221FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-5UTRENST00000476794ENST00000596315FNDC3Bchr3

171969331

+EMP3chr19

48832609

+
intron-5UTRENST00000476794ENST00000597279FNDC3Bchr3

171969331

+EMP3chr19

48832609

+

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FusionProtFeatures for FNDC3B_EMP3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNDC3B

Q53EP0

EMP3

P54852

Probably involved in cell proliferation and cell-cellinteractions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+626231_2432631205Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+626231_2432631205Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+626231_2432631205Compositional biasNote=Poly-Gly
TgeneEMP3chr3:171969331chr19:48832609ENST00000270221+25100_12060164TransmembraneHelical
TgeneEMP3chr3:171969331chr19:48832609ENST00000270221+25139_15960164TransmembraneHelical
TgeneEMP3chr3:171969331chr19:48832609ENST00000270221+2566_8660164TransmembraneHelical
TgeneEMP3chr3:171969331chr19:48832609ENST00000597279+36100_12060164TransmembraneHelical
TgeneEMP3chr3:171969331chr19:48832609ENST00000597279+36139_15960164TransmembraneHelical
TgeneEMP3chr3:171969331chr19:48832609ENST00000597279+3666_8660164TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+14231_243-5872Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+14231_243-3372Compositional biasNote=Poly-Gly
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+6261056_11532631205DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+626278_3772631205DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+626381_4732631205DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+626477_5702631205DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+626574_6692631205DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+626673_7652631205DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+626766_8592631205DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+626871_9572631205DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+626958_10522631205DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+6261056_11532631205DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+626278_3772631205DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+626381_4732631205DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+626477_5702631205DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+626574_6692631205DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+626673_7652631205DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+626766_8592631205DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+626871_9572631205DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+626958_10522631205DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+6261056_11532631205DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+626278_3772631205DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+626381_4732631205DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+626477_5702631205DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+626574_6692631205DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+626673_7652631205DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+626766_8592631205DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+626871_9572631205DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+626958_10522631205DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+141056_1153-5872DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+14278_377-5872DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+14381_473-5872DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+14477_570-5872DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+14574_669-5872DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+14673_765-5872DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+14766_859-5872DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+14871_957-5872DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+14958_1052-5872DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+141056_1153-3372DomainFibronectin type-III 9
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+14278_377-3372DomainFibronectin type-III 1
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+14381_473-3372DomainFibronectin type-III 2
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+14477_570-3372DomainFibronectin type-III 3
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+14574_669-3372DomainFibronectin type-III 4
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+14673_765-3372DomainFibronectin type-III 5
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+14766_859-3372DomainFibronectin type-III 6
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+14871_957-3372DomainFibronectin type-III 7
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+14958_1052-3372DomainFibronectin type-III 8
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000336824+6261182_12022631205TransmembraneHelical
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000415807+6261182_12022631205TransmembraneHelical
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000416957+6261182_12022631205TransmembraneHelical
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000421757+141182_1202-5872TransmembraneHelical
HgeneFNDC3Bchr3:171969331chr19:48832609ENST00000423424+141182_1202-3372TransmembraneHelical
TgeneEMP3chr3:171969331chr19:48832609ENST00000270221+254_2460164TransmembraneHelical
TgeneEMP3chr3:171969331chr19:48832609ENST00000597279+364_2460164TransmembraneHelical


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FusionGeneSequence for FNDC3B_EMP3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FNDC3B_ENST00000415807_chr3_171969331_+_EMP3_ENST00000270221_chr19_48832609_+_367aa
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQVI
EDSTGVRRVVVTPQSPECYPPSYPSAMSPTHHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGSGPGIKKTERRARSSPKSNDSDLQGWLKAVQ
VLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGLCQLCTSVAVFTGALIYAIHAEEILEKHPRGGSFGYCFALAWVAFPLALVSGIIYI

>In-frame_FNDC3B_ENST00000336824_chr3_171969331_+_EMP3_ENST00000270221_chr19_48832609_+_367aa
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQVI
EDSTGVRRVVVTPQSPECYPPSYPSAMSPTHHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGSGPGIKKTERRARSSPKSNDSDLQGWLKAVQ
VLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGLCQLCTSVAVFTGALIYAIHAEEILEKHPRGGSFGYCFALAWVAFPLALVSGIIYI

>In-frame_FNDC3B_ENST00000416957_chr3_171969331_+_EMP3_ENST00000270221_chr19_48832609_+_367aa
MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVNPGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQVI
EDSTGVRRVVVTPQSPECYPPSYPSAMSPTHHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHHLPHTIYGEQEIIPFYGMSTY
ITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSCTTVYNGYGKGHSGGSGGGGSGSGPGIKKTERRARSSPKSNDSDLQGWLKAVQ
VLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGLCQLCTSVAVFTGALIYAIHAEEILEKHPRGGSFGYCFALAWVAFPLALVSGIIYI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FNDC3B_ENST00000415807_chr3_171969331_+_EMP3_ENST00000270221_chr19_48832609_+_1101nt
ATGTACGTCACAATGATGATGACCGACCAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCCCACTTGGTG
AATGGAGATGCAGCTCAGCAGGTTATTCTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACACTTCAGTGC
ATTCAAGGACCTGCTGAAGTTCCCATGATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCACAGGTGATT
GAAGATAGTACTGGAGTCCGCCGGGTGGTGGTCACACCCCAGTCTCCTGAGTGTTATCCCCCAAGCTACCCCTCAGCCATGTCTCCAACC
CATCATCTCCCTCCCTATCTGACTCACCATCCACATTTTATTCATAACTCACACACGGCTTACTACCCACCTGTTACCGGACCTGGAGAT
ATGCCGCCTCAGTTTTTTCCCCAGCATCATCTTCCCCACACAATATATGGTGAGCAAGAAATTATACCATTTTATGGAATGTCAACCTAC
ATCACCCGAGAAGACCAGTACAGCAAGCCTCCGCACAAAAAACTGAAAGACCGCCAGATCGATCGCCAGAACCGCCTCAACAGCCCTCCT
TCTTCTATCTACAAAAGCAGCTGCACAACAGTATACAATGGCTATGGGAAGGGCCATAGTGGTGGAAGTGGCGGAGGCGGCAGCGGTAGT
GGTCCCGGAATTAAGAAAACAGAGCGACGAGCAAGAAGCAGCCCAAAGTCGAATGATTCAGACTTGCAAGGCTGGCTGAAGGCGGTGCAG
GTCCTCATGGTGCTCTCCCTCATTCTCTGCTGTCTCTCCTTCATCCTGTTCATGTTCCAGCTCTACACCATGCGACGAGGAGGTCTCTTC
TATGCCACCGGCCTCTGCCAGCTTTGCACCAGCGTGGCGGTGTTTACTGGCGCCTTGATCTATGCCATTCACGCCGAGGAGATCCTGGAG
AAGCACCCGCGAGGGGGCAGCTTCGGATACTGCTTCGCCCTGGCCTGGGTGGCCTTCCCCCTCGCCCTGGTCAGCGGCATCATCTACATC

>In-frame_FNDC3B_ENST00000336824_chr3_171969331_+_EMP3_ENST00000270221_chr19_48832609_+_1101nt
ATGTACGTCACAATGATGATGACCGACCAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCCCACTTGGTG
AATGGAGATGCAGCTCAGCAGGTTATTCTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACACTTCAGTGC
ATTCAAGGACCTGCTGAAGTTCCCATGATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCACAGGTGATT
GAAGATAGTACTGGAGTCCGCCGGGTGGTGGTCACACCCCAGTCTCCTGAGTGTTATCCCCCAAGCTACCCCTCAGCCATGTCTCCAACC
CATCATCTCCCTCCCTATCTGACTCACCATCCACATTTTATTCATAACTCACACACGGCTTACTACCCACCTGTTACCGGACCTGGAGAT
ATGCCGCCTCAGTTTTTTCCCCAGCATCATCTTCCCCACACAATATATGGTGAGCAAGAAATTATACCATTTTATGGAATGTCAACCTAC
ATCACCCGAGAAGACCAGTACAGCAAGCCTCCGCACAAAAAACTGAAAGACCGCCAGATCGATCGCCAGAACCGCCTCAACAGCCCTCCT
TCTTCTATCTACAAAAGCAGCTGCACAACAGTATACAATGGCTATGGGAAGGGCCATAGTGGTGGAAGTGGCGGAGGCGGCAGCGGTAGT
GGTCCCGGAATTAAGAAAACAGAGCGACGAGCAAGAAGCAGCCCAAAGTCGAATGATTCAGACTTGCAAGGCTGGCTGAAGGCGGTGCAG
GTCCTCATGGTGCTCTCCCTCATTCTCTGCTGTCTCTCCTTCATCCTGTTCATGTTCCAGCTCTACACCATGCGACGAGGAGGTCTCTTC
TATGCCACCGGCCTCTGCCAGCTTTGCACCAGCGTGGCGGTGTTTACTGGCGCCTTGATCTATGCCATTCACGCCGAGGAGATCCTGGAG
AAGCACCCGCGAGGGGGCAGCTTCGGATACTGCTTCGCCCTGGCCTGGGTGGCCTTCCCCCTCGCCCTGGTCAGCGGCATCATCTACATC

>In-frame_FNDC3B_ENST00000416957_chr3_171969331_+_EMP3_ENST00000270221_chr19_48832609_+_1101nt
ATGTACGTCACAATGATGATGACCGACCAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCCCACTTGGTG
AATGGAGATGCAGCTCAGCAGGTTATTCTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACACTTCAGTGC
ATTCAAGGACCTGCTGAAGTTCCCATGATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCACAGGTGATT
GAAGATAGTACTGGAGTCCGCCGGGTGGTGGTCACACCCCAGTCTCCTGAGTGTTATCCCCCAAGCTACCCCTCAGCCATGTCTCCAACC
CATCATCTCCCTCCCTATCTGACTCACCATCCACATTTTATTCATAACTCACACACGGCTTACTACCCACCTGTTACCGGACCTGGAGAT
ATGCCGCCTCAGTTTTTTCCCCAGCATCATCTTCCCCACACAATATATGGTGAGCAAGAAATTATACCATTTTATGGAATGTCAACCTAC
ATCACCCGAGAAGACCAGTACAGCAAGCCTCCGCACAAAAAACTGAAAGACCGCCAGATCGATCGCCAGAACCGCCTCAACAGCCCTCCT
TCTTCTATCTACAAAAGCAGCTGCACAACAGTATACAATGGCTATGGGAAGGGCCATAGTGGTGGAAGTGGCGGAGGCGGCAGCGGTAGT
GGTCCCGGAATTAAGAAAACAGAGCGACGAGCAAGAAGCAGCCCAAAGTCGAATGATTCAGACTTGCAAGGCTGGCTGAAGGCGGTGCAG
GTCCTCATGGTGCTCTCCCTCATTCTCTGCTGTCTCTCCTTCATCCTGTTCATGTTCCAGCTCTACACCATGCGACGAGGAGGTCTCTTC
TATGCCACCGGCCTCTGCCAGCTTTGCACCAGCGTGGCGGTGTTTACTGGCGCCTTGATCTATGCCATTCACGCCGAGGAGATCCTGGAG
AAGCACCCGCGAGGGGGCAGCTTCGGATACTGCTTCGCCCTGGCCTGGGTGGCCTTCCCCCTCGCCCTGGTCAGCGGCATCATCTACATC


* Fusion transcript sequences (Full-length transcript).
>In-frame_FNDC3B_ENST00000415807_chr3_171969331_+_EMP3_ENST00000270221_chr19_48832609_+_1356nt
GCGGCGGCGGCGGCTGGAGGAGGAGAGCGGCGGCGGCGGGAGCAGCGAAGGGGGCGGCAGGGATCCTCCAGGCTGCCGGCTGGGAAGGCG
TGGGCGACCCGGTGTGTGGCGCGCCCAGAGCCCCGCGTTTCAGCCCTAGGGAAGGAAGCCAGTTGAGGGAAGTTCTCCATGAATGTACGT
CACAATGATGATGACCGACCAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCCCACTTGGTGAATGGAGA
TGCAGCTCAGCAGGTTATTCTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACACTTCAGTGCATTCAAGG
ACCTGCTGAAGTTCCCATGATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCACAGGTGATTGAAGATAG
TACTGGAGTCCGCCGGGTGGTGGTCACACCCCAGTCTCCTGAGTGTTATCCCCCAAGCTACCCCTCAGCCATGTCTCCAACCCATCATCT
CCCTCCCTATCTGACTCACCATCCACATTTTATTCATAACTCACACACGGCTTACTACCCACCTGTTACCGGACCTGGAGATATGCCGCC
TCAGTTTTTTCCCCAGCATCATCTTCCCCACACAATATATGGTGAGCAAGAAATTATACCATTTTATGGAATGTCAACCTACATCACCCG
AGAAGACCAGTACAGCAAGCCTCCGCACAAAAAACTGAAAGACCGCCAGATCGATCGCCAGAACCGCCTCAACAGCCCTCCTTCTTCTAT
CTACAAAAGCAGCTGCACAACAGTATACAATGGCTATGGGAAGGGCCATAGTGGTGGAAGTGGCGGAGGCGGCAGCGGTAGTGGTCCCGG
AATTAAGAAAACAGAGCGACGAGCAAGAAGCAGCCCAAAGTCGAATGATTCAGACTTGCAAGGCTGGCTGAAGGCGGTGCAGGTCCTCAT
GGTGCTCTCCCTCATTCTCTGCTGTCTCTCCTTCATCCTGTTCATGTTCCAGCTCTACACCATGCGACGAGGAGGTCTCTTCTATGCCAC
CGGCCTCTGCCAGCTTTGCACCAGCGTGGCGGTGTTTACTGGCGCCTTGATCTATGCCATTCACGCCGAGGAGATCCTGGAGAAGCACCC
GCGAGGGGGCAGCTTCGGATACTGCTTCGCCCTGGCCTGGGTGGCCTTCCCCCTCGCCCTGGTCAGCGGCATCATCTACATCCACCTACG
GAAGCGGGAGTGAGCGCCCCGCCTCGCTCGGCTGCCCCCGCCCCTTCCCGGCCCCCCTCGCCGCGCGTCCTCCAAAAAATAAAACCTTAA

>In-frame_FNDC3B_ENST00000336824_chr3_171969331_+_EMP3_ENST00000270221_chr19_48832609_+_1283nt
AAGCTCGGGCGGGGGAGCGGGGCGCGGCGGGAAGGAGCGGGCGACCCGGTGTGTGGGCCAGCGGAGCTCCGGAAGCCAGTTGAGGGAAGT
TCTCCATGAATGTACGTCACAATGATGATGACCGACCAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCC
CACTTGGTGAATGGAGATGCAGCTCAGCAGGTTATTCTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACA
CTTCAGTGCATTCAAGGACCTGCTGAAGTTCCCATGATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCA
CAGGTGATTGAAGATAGTACTGGAGTCCGCCGGGTGGTGGTCACACCCCAGTCTCCTGAGTGTTATCCCCCAAGCTACCCCTCAGCCATG
TCTCCAACCCATCATCTCCCTCCCTATCTGACTCACCATCCACATTTTATTCATAACTCACACACGGCTTACTACCCACCTGTTACCGGA
CCTGGAGATATGCCGCCTCAGTTTTTTCCCCAGCATCATCTTCCCCACACAATATATGGTGAGCAAGAAATTATACCATTTTATGGAATG
TCAACCTACATCACCCGAGAAGACCAGTACAGCAAGCCTCCGCACAAAAAACTGAAAGACCGCCAGATCGATCGCCAGAACCGCCTCAAC
AGCCCTCCTTCTTCTATCTACAAAAGCAGCTGCACAACAGTATACAATGGCTATGGGAAGGGCCATAGTGGTGGAAGTGGCGGAGGCGGC
AGCGGTAGTGGTCCCGGAATTAAGAAAACAGAGCGACGAGCAAGAAGCAGCCCAAAGTCGAATGATTCAGACTTGCAAGGCTGGCTGAAG
GCGGTGCAGGTCCTCATGGTGCTCTCCCTCATTCTCTGCTGTCTCTCCTTCATCCTGTTCATGTTCCAGCTCTACACCATGCGACGAGGA
GGTCTCTTCTATGCCACCGGCCTCTGCCAGCTTTGCACCAGCGTGGCGGTGTTTACTGGCGCCTTGATCTATGCCATTCACGCCGAGGAG
ATCCTGGAGAAGCACCCGCGAGGGGGCAGCTTCGGATACTGCTTCGCCCTGGCCTGGGTGGCCTTCCCCCTCGCCCTGGTCAGCGGCATC
ATCTACATCCACCTACGGAAGCGGGAGTGAGCGCCCCGCCTCGCTCGGCTGCCCCCGCCCCTTCCCGGCCCCCCTCGCCGCGCGTCCTCC

>In-frame_FNDC3B_ENST00000416957_chr3_171969331_+_EMP3_ENST00000270221_chr19_48832609_+_1247nt
AGTGTCTACCACCAAACTCCTAAGGCTGGATGGTGGAAGCCAGTTGAGGGAAGTTCTCCATGAATGTACGTCACAATGATGATGACCGAC
CAAATCCCTCTGGAACTGCCACCATTGCTGAACGGAGAGGTAGCCATGATGCCCCACTTGGTGAATGGAGATGCAGCTCAGCAGGTTATT
CTCGTTCAAGTTAATCCAGGTGAGACTTTCACAATAAGAGCAGAGGATGGAACACTTCAGTGCATTCAAGGACCTGCTGAAGTTCCCATG
ATGTCACCCAATGGATCCATTCCTCCCATTCATGTGCCTCCAGGTTATATCTCACAGGTGATTGAAGATAGTACTGGAGTCCGCCGGGTG
GTGGTCACACCCCAGTCTCCTGAGTGTTATCCCCCAAGCTACCCCTCAGCCATGTCTCCAACCCATCATCTCCCTCCCTATCTGACTCAC
CATCCACATTTTATTCATAACTCACACACGGCTTACTACCCACCTGTTACCGGACCTGGAGATATGCCGCCTCAGTTTTTTCCCCAGCAT
CATCTTCCCCACACAATATATGGTGAGCAAGAAATTATACCATTTTATGGAATGTCAACCTACATCACCCGAGAAGACCAGTACAGCAAG
CCTCCGCACAAAAAACTGAAAGACCGCCAGATCGATCGCCAGAACCGCCTCAACAGCCCTCCTTCTTCTATCTACAAAAGCAGCTGCACA
ACAGTATACAATGGCTATGGGAAGGGCCATAGTGGTGGAAGTGGCGGAGGCGGCAGCGGTAGTGGTCCCGGAATTAAGAAAACAGAGCGA
CGAGCAAGAAGCAGCCCAAAGTCGAATGATTCAGACTTGCAAGGCTGGCTGAAGGCGGTGCAGGTCCTCATGGTGCTCTCCCTCATTCTC
TGCTGTCTCTCCTTCATCCTGTTCATGTTCCAGCTCTACACCATGCGACGAGGAGGTCTCTTCTATGCCACCGGCCTCTGCCAGCTTTGC
ACCAGCGTGGCGGTGTTTACTGGCGCCTTGATCTATGCCATTCACGCCGAGGAGATCCTGGAGAAGCACCCGCGAGGGGGCAGCTTCGGA
TACTGCTTCGCCCTGGCCTGGGTGGCCTTCCCCCTCGCCCTGGTCAGCGGCATCATCTACATCCACCTACGGAAGCGGGAGTGAGCGCCC


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FusionGenePPI for FNDC3B_EMP3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FNDC3BELAVL1, CAMK2D, TRAF2, TRIP13, TOX4, VAC14, SPINT2, RBFOX2, FAM46A, FAM189B, KLRG2, G3BP1EMP3CREM, EDA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FNDC3B_EMP3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FNDC3B_EMP3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFNDC3BC0022578Keratoconus1CTD_human
HgeneFNDC3BC0339573Glaucoma, Primary Open Angle1CTD_human
TgeneEMP3C0033578Prostatic Neoplasms1CTD_human