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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13678

FusionGeneSummary for FNDC3B_BCHE

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3B_BCHE
Fusion gene ID: 13678
HgeneTgene
Gene symbol

FNDC3B

BCHE

Gene ID

64778

590

Gene namefibronectin type III domain containing 3Bbutyrylcholinesterase
SynonymsFAD104|PRO4979|YVTM2421BCHED|CHE1|CHE2|E1
Cytomap

3q26.31

3q26.1

Type of geneprotein-codingprotein-coding
Descriptionfibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104cholinesteraseacylcholine acylhydrolasebutyrylcholine esterasecholine esterase IIcholinesterase (serum) 2cholinesterase 1pseudocholinesterase
Modification date2018051920180519
UniProtAcc

Q53EP0

P06276

Ensembl transtripts involved in fusion geneENST00000415807, ENST00000336824, 
ENST00000416957, ENST00000392699, 
ENST00000421757, ENST00000423424, 
ENST00000476794, 		ENST00000264381, 
ENST00000540653, 
Fusion gene scores* DoF score22 X 10 X 13=28601 X 1 X 1=1
# samples 241
** MAII scorelog2(24/2860*10)=-3.57490883605723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: FNDC3B [Title/Abstract] AND BCHE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-G7-6793-01AFNDC3Bchr3

171851336

+BCHEchr3

165504099

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000415807ENST00000264381FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
5CDS-5UTRENST00000415807ENST00000540653FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
Frame-shiftENST00000336824ENST00000264381FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
5CDS-5UTRENST00000336824ENST00000540653FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
Frame-shiftENST00000416957ENST00000264381FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
5CDS-5UTRENST00000416957ENST00000540653FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
Frame-shiftENST00000392699ENST00000264381FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
5CDS-5UTRENST00000392699ENST00000540653FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
Frame-shiftENST00000421757ENST00000264381FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
5CDS-5UTRENST00000421757ENST00000540653FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
Frame-shiftENST00000423424ENST00000264381FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
5CDS-5UTRENST00000423424ENST00000540653FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
intron-3CDSENST00000476794ENST00000264381FNDC3Bchr3

171851336

+BCHEchr3

165504099

-
intron-5UTRENST00000476794ENST00000540653FNDC3Bchr3

171851336

+BCHEchr3

165504099

-

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FusionProtFeatures for FNDC3B_BCHE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNDC3B

Q53EP0

BCHE

P06276

Esterase with broad substrate specificity. Contributesto the inactivation of the neurotransmitter acetylcholine. Candegrade neurotoxic organophosphate esters.{ECO:0000269|PubMed:19452557, ECO:0000269|PubMed:19542320}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FNDC3B_BCHE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FNDC3B_BCHE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FNDC3BELAVL1, CAMK2D, TRAF2, TRIP13, TOX4, VAC14, SPINT2, RBFOX2, FAM46A, FAM189B, KLRG2, G3BP1BCHEBCHE, COLQ, PTPRK, LOXL1, ENTPD5, LTBP1, NAF1, ACTN3, PALLD, KIAA1598, SMR3B, TUBA3C, DKC1, MANEAL, DEFA1, DIAPH3, FBXO2, NOP10, SLAMF1, SCGB1D4, SCGB1D1, CTAGE5, FAM120A, SF1, ASPH, WASL, CPSF7, NHP2, ENAH


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FNDC3B_BCHE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneBCHEP06276DB00449DipivefrinCholinesterasesmall moleculeapproved
TgeneBCHEP06276DB00674GalantamineCholinesterasesmall moleculeapproved
TgeneBCHEP06276DB00863RanitidineCholinesterasesmall moleculeapproved
TgeneBCHEP06276DB00941HexafluroniumCholinesterasesmall moleculeapproved
TgeneBCHEP06276DB00944DemecariumCholinesterasesmall moleculeapproved
TgeneBCHEP06276DB01057EchothiophateCholinesterasesmall moleculeapproved
TgeneBCHEP06276DB01226MivacuriumCholinesterasesmall moleculeapproved
TgeneBCHEP06276DB00545PyridostigmineCholinesterasesmall moleculeapproved|investigational
TgeneBCHEP06276DB00772MalathionCholinesterasesmall moleculeapproved|investigational
TgeneBCHEP06276DB00989RivastigmineCholinesterasesmall moleculeapproved|investigational
TgeneBCHEP06276DB00122CholineCholinesterasesmall moleculeapproved|nutraceutical
TgeneBCHEP06276DB00733PralidoximeCholinesterasesmall moleculeapproved|vet_approved
TgeneBCHEP06276DB01221KetamineCholinesterasesmall moleculeapproved|vet_approved

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RelatedDiseases for FNDC3B_BCHE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFNDC3BC0022578Keratoconus1CTD_human
HgeneFNDC3BC0339573Glaucoma, Primary Open Angle1CTD_human
TgeneBCHEC0003578Apnea31CTD_human
TgeneBCHEC0522224Paralysed10CTD_human
TgeneBCHEC0236736Cocaine-Related Disorders8CTD_human
TgeneBCHEC0700359Organophosphate poisoning7CTD_human
TgeneBCHEC1283400Butyrylcholinesterase deficiency5CTD_human;ORPHANET
TgeneBCHEC0028754Obesity4CTD_human
TgeneBCHEC0036572Seizures3CTD_human
TgeneBCHEC0009241Cognition Disorders2CTD_human
TgeneBCHEC0001969Alcoholic Intoxication1PSYGENET
TgeneBCHEC0002395Alzheimer's Disease1CTD_human
TgeneBCHEC0005586Bipolar Disorder1PSYGENET
TgeneBCHEC0007134Renal Cell Carcinoma1CTD_human
TgeneBCHEC0014549Tonic-Clonic Epilepsy1CTD_human
TgeneBCHEC0015644Muscular fasciculation1CTD_human
TgeneBCHEC0017636Glioblastoma1CTD_human
TgeneBCHEC0020557Hypertriglyceridemia1CTD_human
TgeneBCHEC0026769Multiple Sclerosis1CTD_human
TgeneBCHEC0026850Muscular Dystrophy1CTD_human
TgeneBCHEC0027819Neuroblastoma1CTD_human
TgeneBCHEC0030552Paresis1CTD_human
TgeneBCHEC0032787Postoperative Complications1CTD_human
TgeneBCHEC0037315Sleep Apnea Syndromes1CTD_human
TgeneBCHEC0039231Tachycardia1CTD_human
TgeneBCHEC0041105Trismus1CTD_human
TgeneBCHEC0041755Adverse reaction to drug1CTD_human
TgeneBCHEC0235032Neurotoxicity Syndromes1CTD_human
TgeneBCHEC0424295Hyperactive behavior1CTD_human
TgeneBCHEC0876994Cardiotoxicity1CTD_human
TgeneBCHEC1458155Mammary Neoplasms1CTD_human
TgeneBCHEC1855794Bamforth syndrome1CTD_human