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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13677

FusionGeneSummary for FNDC3B_ATP13A4

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3B_ATP13A4
Fusion gene ID: 13677
HgeneTgene
Gene symbol

FNDC3B

ATP13A4

Gene ID

64778

84239

Gene namefibronectin type III domain containing 3BATPase 13A4
SynonymsFAD104|PRO4979|YVTM2421-
Cytomap

3q26.31

3q29

Type of geneprotein-codingprotein-coding
Descriptionfibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104probable cation-transporting ATPase 13A4ATPase type 13A4P5-ATPasecation-transporting P5-ATPase
Modification date2018051920180523
UniProtAcc

Q53EP0

Q4VNC1

Ensembl transtripts involved in fusion geneENST00000415807, ENST00000336824, 
ENST00000416957, ENST00000392699, 
ENST00000421757, ENST00000423424, 
ENST00000476794, 
ENST00000392443, 
ENST00000342695, ENST00000295548, 
ENST00000400270, ENST00000482964, 
Fusion gene scores* DoF score22 X 10 X 13=28602 X 2 X 2=8
# samples 242
** MAII scorelog2(24/2860*10)=-3.57490883605723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: FNDC3B [Title/Abstract] AND ATP13A4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-95-7039-01AFNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000415807ENST00000392443FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000415807ENST00000342695FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000415807ENST00000295548FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000415807ENST00000400270FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000415807ENST00000482964FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000336824ENST00000392443FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000336824ENST00000342695FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000336824ENST00000295548FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000336824ENST00000400270FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000336824ENST00000482964FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000416957ENST00000392443FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000416957ENST00000342695FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000416957ENST00000295548FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000416957ENST00000400270FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000416957ENST00000482964FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000392699ENST00000392443FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000392699ENST00000342695FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000392699ENST00000295548FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000392699ENST00000400270FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000392699ENST00000482964FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000421757ENST00000392443FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000421757ENST00000342695FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000421757ENST00000295548FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000421757ENST00000400270FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000421757ENST00000482964FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000423424ENST00000392443FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000423424ENST00000342695FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
Frame-shitENST00000423424ENST00000295548FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000423424ENST00000400270FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
5CDS-intronENST00000423424ENST00000482964FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
intron-3CDSENST00000476794ENST00000392443FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
intron-3CDSENST00000476794ENST00000342695FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
intron-3CDSENST00000476794ENST00000295548FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
intron-intronENST00000476794ENST00000400270FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-
intron-intronENST00000476794ENST00000482964FNDC3Bchr3

171851336

+ATP13A4chr3

193232660

-

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FusionProtFeatures for FNDC3B_ATP13A4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNDC3B

Q53EP0

ATP13A4

Q4VNC1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FNDC3B_ATP13A4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FNDC3B_ATP13A4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FNDC3BELAVL1, CAMK2D, TRAF2, TRIP13, TOX4, VAC14, SPINT2, RBFOX2, FAM46A, FAM189B, KLRG2, G3BP1ATP13A4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FNDC3B_ATP13A4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FNDC3B_ATP13A4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFNDC3BC0022578Keratoconus1CTD_human
HgeneFNDC3BC0339573Glaucoma, Primary Open Angle1CTD_human