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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13671

FusionGeneSummary for FNDC3A_FGF14-IT1

check button Fusion gene summary
Fusion gene informationFusion gene name: FNDC3A_FGF14-IT1
Fusion gene ID: 13671
HgeneTgene
Gene symbol

FNDC3A

FGF14-IT1

Gene ID

22862

283480

Gene namefibronectin type III domain containing 3AFGF14 intronic transcript 1
SynonymsFNDC3|HUGO|bA203I16.1|bA203I16.5-
Cytomap

13q14.2

13q33.1

Type of geneprotein-codingncRNA
Descriptionfibronectin type-III domain-containing protein 3Ahuman gene expressed in odontoblastsFGF14 intronic transcript 1 (non-protein coding)
Modification date2018051920180329
UniProtAcc

Q9Y2H6

Ensembl transtripts involved in fusion geneENST00000492622, ENST00000541916, 
ENST00000398316, 
ENST00000607251, 
Fusion gene scores* DoF score8 X 7 X 6=3361 X 1 X 1=1
# samples 91
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: FNDC3A [Title/Abstract] AND FGF14-IT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-DU-7007-01AFNDC3Achr13

49720071

+FGF14-IT1chr13

102946390

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000492622ENST00000607251FNDC3Achr13

49720071

+FGF14-IT1chr13

102946390

-
5CDS-5UTRENST00000541916ENST00000607251FNDC3Achr13

49720071

+FGF14-IT1chr13

102946390

-
5CDS-5UTRENST00000398316ENST00000607251FNDC3Achr13

49720071

+FGF14-IT1chr13

102946390

-

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FusionProtFeatures for FNDC3A_FGF14-IT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNDC3A

Q9Y2H6

FGF14-IT1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FNDC3A_FGF14-IT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FNDC3A_FGF14-IT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FNDC3AELAVL1, APP, SPINT2, TMEM51, KCNK16, DLK1, HERC2, EVC2, TMEM17, HNRNPD, SORT1, NIPSNAP1, SMC3, VAPA, SYNCRIP, FAM46A, RBM45, CEP170P1, BAG6, CENPU, FPR2, SYT3, IL27RA, CD1E, FADS3, CLEC2D, PDGFRB, PCDHGA5, GRAMD1B, GRPR, SLC22A16, AP3S1, TRIM25FGF14-IT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FNDC3A_FGF14-IT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FNDC3A_FGF14-IT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource