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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1367

FusionGeneSummary for AKAP9_RUNX1

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP9_RUNX1
Fusion gene ID: 1367
HgeneTgene
Gene symbol

AKAP9

RUNX1

Gene ID

10142

861

Gene nameA-kinase anchoring protein 9runt related transcription factor 1
SynonymsAKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAOAML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alpha
Cytomap

7q21.2

21q22.12

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associrunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2
Modification date2018052320180527
UniProtAcc

Q99996

Q01196

Ensembl transtripts involved in fusion geneENST00000356239, ENST00000358100, 
ENST00000359028, ENST00000394564, 
ENST00000491695, 
ENST00000344691, 
ENST00000325074, ENST00000437180, 
ENST00000300305, ENST00000399240, 
ENST00000486278, ENST00000494829, 
ENST00000358356, 
Fusion gene scores* DoF score12 X 12 X 7=100817 X 29 X 7=3451
# samples 2233
** MAII scorelog2(22/1008*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(33/3451*10)=-3.3864765441897
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP9 [Title/Abstract] AND RUNX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745

TgeneRUNX1

GO:0030097

hemopoiesis

21873977

TgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

TgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-OL-A5RW-01AAKAP9chr7

91699496

+RUNX1chr21

36171759

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000356239ENST00000344691AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000356239ENST00000325074AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000356239ENST00000437180AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000356239ENST00000300305AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000356239ENST00000399240AKAP9chr7

91699496

+RUNX1chr21

36171759

-
5CDS-intronENST00000356239ENST00000486278AKAP9chr7

91699496

+RUNX1chr21

36171759

-
5CDS-intronENST00000356239ENST00000494829AKAP9chr7

91699496

+RUNX1chr21

36171759

-
5CDS-intronENST00000356239ENST00000358356AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000358100ENST00000344691AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000358100ENST00000325074AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000358100ENST00000437180AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000358100ENST00000300305AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000358100ENST00000399240AKAP9chr7

91699496

+RUNX1chr21

36171759

-
5CDS-intronENST00000358100ENST00000486278AKAP9chr7

91699496

+RUNX1chr21

36171759

-
5CDS-intronENST00000358100ENST00000494829AKAP9chr7

91699496

+RUNX1chr21

36171759

-
5CDS-intronENST00000358100ENST00000358356AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000359028ENST00000344691AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000359028ENST00000325074AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000359028ENST00000437180AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000359028ENST00000300305AKAP9chr7

91699496

+RUNX1chr21

36171759

-
Frame-shitENST00000359028ENST00000399240AKAP9chr7

91699496

+RUNX1chr21

36171759

-
5CDS-intronENST00000359028ENST00000486278AKAP9chr7

91699496

+RUNX1chr21

36171759

-
5CDS-intronENST00000359028ENST00000494829AKAP9chr7

91699496

+RUNX1chr21

36171759

-
5CDS-intronENST00000359028ENST00000358356AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-3CDSENST00000394564ENST00000344691AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-3CDSENST00000394564ENST00000325074AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-3CDSENST00000394564ENST00000437180AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-3CDSENST00000394564ENST00000300305AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-3CDSENST00000394564ENST00000399240AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-intronENST00000394564ENST00000486278AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-intronENST00000394564ENST00000494829AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-intronENST00000394564ENST00000358356AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-3CDSENST00000491695ENST00000344691AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-3CDSENST00000491695ENST00000325074AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-3CDSENST00000491695ENST00000437180AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-3CDSENST00000491695ENST00000300305AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-3CDSENST00000491695ENST00000399240AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-intronENST00000491695ENST00000486278AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-intronENST00000491695ENST00000494829AKAP9chr7

91699496

+RUNX1chr21

36171759

-
intron-intronENST00000491695ENST00000358356AKAP9chr7

91699496

+RUNX1chr21

36171759

-

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FusionProtFeatures for AKAP9_RUNX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP9

Q99996

RUNX1

Q01196


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AKAP9_RUNX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AKAP9_RUNX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AKAP9TACC3, FNBP1, TRIP10, PRKAR2A, KCNQ1, CLIC1, CALM2, CALM1, TUBGCP3, PKN1, CSNK1D, PMS1, CDC5L, DISC1, TNIK, CEBPA, CCNE1, TSG101, CDK5RAP2, KDM1A, TDP2, PCNT, GSK3A, RASSF2, SUV39H2, PRKACA, PRKACB, MAGEA6, HNRNPM, SSX2, BLZF1, USO1, MAGED1, IKZF3, WAC, THAP1, PRDM14, USHBP1, C1orf94, SAMD3, SUZ12, RNF2, BMI1, ROPN1L, MAPRE1, CEP170, CCDC68, PRKAR2B, HERC2, GPC4, DYNLL1, HUWE1, FGFR1OP, THOC2, CEP170P1, PCGF1, NANOG, ATOH1, TPTE2, PDE4DIP, PRKACG, C1orf87, DNAJC10, BIRC6, TPM2, HEY1RUNX1SUV39H1, KAT6B, CBFB, AES, PAX5, YAP1, JUN, FOS, SMAD3, SMAD1, SMAD2, SMAD5, VDR, ELF4, ELF2, CEBPB, TLE1, CBFA2T2, TRAF6, FHL2, MYOD1, HIPK2, EP300, HDAC1, HDAC3, KAT6A, TCF12, TCF3, RUNX1T1, NCOR1, SIAH1, UBE2L6, RUNX1, PML, RARA, HDAC2, SIN3A, NR4A2, TRIM33, STUB1, SMARCA4, SMARCB1, SMARCC1, CDK1, TAL1, COPRS, KMT2A, RBM14, SPEN, DNMT1, ELAVL1, CBFA2T3, PRMT1, HLA-DMA, CREBBP, UXT, CTBP2, NOTCH1, MYC, NCOR2, FOXP3, SOX2, CTBP1, HDAC11, RAG1, SPI1, ELF1, CDK6, KLF6, NFATC1, NFATC2, ZNF131, BRCA1, CDK9, FANCD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AKAP9_RUNX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AKAP9_RUNX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP9C0037274Dermatologic disorders1CTD_human
HgeneAKAP9C0311375Arsenic Poisoning1CTD_human
HgeneAKAP9C2678483Long Qt Syndrome 111CTD_human;UNIPROT
TgeneRUNX1C0023467Leukemia, Myelocytic, Acute2CTD_human;HPO
TgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
TgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
TgeneRUNX1C0017636Glioblastoma1CTD_human
TgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
TgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
TgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy1CTD_human;ORPHANET;UNIPROT
TgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human