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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13661

FusionGeneSummary for FNBP1_FNBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: FNBP1_FNBP1
Fusion gene ID: 13661
HgeneTgene
Gene symbol

FNBP1

FNBP1

Gene ID

23048

23048

Gene nameformin binding protein 1formin binding protein 1
SynonymsFBP17FBP17
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionformin-binding protein 1formin-binding protein 17formin-binding protein 1formin-binding protein 17
Modification date2018052920180529
UniProtAcc

Q96RU3

Q96RU3

Ensembl transtripts involved in fusion geneENST00000446176, ENST00000420781, 
ENST00000355681, ENST00000443566, 
ENST00000478129, 
ENST00000446176, 
ENST00000420781, ENST00000355681, 
ENST00000443566, ENST00000478129, 
Fusion gene scores* DoF score3 X 5 X 1=158 X 10 X 3=240
# samples 1014
** MAII scorelog2(10/15*10)=2.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(14/240*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FNBP1 [Title/Abstract] AND FNBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA258146FNBP1chr9

132685592

+FNBP1chr9

132684016

+
ChiTaRS3.1BQ346800FNBP1chr9

132713116

+FNBP1chr9

132705328

+
ChiTaRS3.1AW204690FNBP1chr9

132685592

+FNBP1chr9

132684016

+
ChiTaRS3.1AW968271FNBP1chr9

132685592

+FNBP1chr9

132684016

+
ChiTaRS3.1BF356931FNBP1chr9

132672496

+FNBP1chr9

132672172

+
ChiTaRS3.1AA262084FNBP1chr9

132685592

+FNBP1chr9

132684016

+
ChiTaRS3.1AA824528FNBP1chr9

132685592

+FNBP1chr9

132684016

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000446176ENST00000446176FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000446176ENST00000420781FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000446176ENST00000355681FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000446176ENST00000443566FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000446176ENST00000478129FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000420781ENST00000446176FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000420781ENST00000420781FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000420781ENST00000355681FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000420781ENST00000443566FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000420781ENST00000478129FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000355681ENST00000446176FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000355681ENST00000420781FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000355681ENST00000355681FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000355681ENST00000443566FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000355681ENST00000478129FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000443566ENST00000446176FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000443566ENST00000420781FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000443566ENST00000355681FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000443566ENST00000443566FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000443566ENST00000478129FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000478129ENST00000446176FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000478129ENST00000420781FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000478129ENST00000355681FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000478129ENST00000443566FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000478129ENST00000478129FNBP1chr9

132685592

+FNBP1chr9

132684016

+
intron-intronENST00000446176ENST00000446176FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000446176ENST00000420781FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000446176ENST00000355681FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000446176ENST00000443566FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000446176ENST00000478129FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000420781ENST00000446176FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000420781ENST00000420781FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000420781ENST00000355681FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000420781ENST00000443566FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000420781ENST00000478129FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000355681ENST00000446176FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000355681ENST00000420781FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000355681ENST00000355681FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000355681ENST00000443566FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000355681ENST00000478129FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000443566ENST00000446176FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000443566ENST00000420781FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000443566ENST00000355681FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000443566ENST00000443566FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000443566ENST00000478129FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000478129ENST00000446176FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000478129ENST00000420781FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000478129ENST00000355681FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000478129ENST00000443566FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000478129ENST00000478129FNBP1chr9

132713116

+FNBP1chr9

132705328

+
intron-intronENST00000446176ENST00000446176FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000446176ENST00000420781FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000446176ENST00000355681FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000446176ENST00000443566FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000446176ENST00000478129FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000420781ENST00000446176FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000420781ENST00000420781FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000420781ENST00000355681FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000420781ENST00000443566FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000420781ENST00000478129FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000355681ENST00000446176FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000355681ENST00000420781FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000355681ENST00000355681FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000355681ENST00000443566FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000355681ENST00000478129FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000443566ENST00000446176FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000443566ENST00000420781FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000443566ENST00000355681FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000443566ENST00000443566FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000443566ENST00000478129FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000478129ENST00000446176FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000478129ENST00000420781FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000478129ENST00000355681FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000478129ENST00000443566FNBP1chr9

132672496

+FNBP1chr9

132672172

+
intron-intronENST00000478129ENST00000478129FNBP1chr9

132672496

+FNBP1chr9

132672172

+

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FusionProtFeatures for FNBP1_FNBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FNBP1

Q96RU3

FNBP1

Q96RU3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FNBP1_FNBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FNBP1_FNBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FNBP1_FNBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FNBP1_FNBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource