FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13629

FusionGeneSummary for FN1_APOD

check button Fusion gene summary
Fusion gene informationFusion gene name: FN1_APOD
Fusion gene ID: 13629
HgeneTgene
Gene symbol

FN1

APOD

Gene ID

2335

347

Gene namefibronectin 1apolipoprotein D
SynonymsCIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF|SMDCF-
Cytomap

2q35

3q29

Type of geneprotein-codingprotein-coding
Descriptionfibronectincold-insoluble globulinmigration-stimulating factorapolipoprotein Dapo-D
Modification date2018052720180523
UniProtAcc

P02751

P05090

Ensembl transtripts involved in fusion geneENST00000421182, ENST00000357867, 
ENST00000323926, ENST00000336916, 
ENST00000354785, ENST00000357009, 
ENST00000346544, ENST00000345488, 
ENST00000359671, ENST00000446046, 
ENST00000443816, ENST00000432072, 
ENST00000356005, ENST00000490833, 
ENST00000426059, 
ENST00000343267, 
Fusion gene scores* DoF score20 X 22 X 6=26403 X 3 X 3=27
# samples 243
** MAII scorelog2(24/2640*10)=-3.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FN1 [Title/Abstract] AND APOD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFN1

GO:0001932

regulation of protein phosphorylation

11792823

HgeneFN1

GO:0008284

positive regulation of cell proliferation

25834989

HgeneFN1

GO:0010628

positive regulation of gene expression

25834989

HgeneFN1

GO:0018149

peptide cross-linking

3997886

HgeneFN1

GO:0034446

substrate adhesion-dependent cell spreading

16236823

HgeneFN1

GO:0035987

endodermal cell differentiation

23154389

HgeneFN1

GO:0048146

positive regulation of fibroblast proliferation

25834989

HgeneFN1

GO:0051702

interaction with symbiont

12167537|12421310|19429745

HgeneFN1

GO:0052047

interaction with other organism via secreted substance involved in symbiotic interaction

17849409

HgeneFN1

GO:0070372

regulation of ERK1 and ERK2 cascade

11792823

HgeneFN1

GO:1904237

positive regulation of substrate-dependent cell migration, cell attachment to substrate

25834989

HgeneFN1

GO:2001202

negative regulation of transforming growth factor-beta secretion

25834989

TgeneAPOD

GO:0000302

response to reactive oxygen species

18419796

TgeneAPOD

GO:0006006

glucose metabolic process

19176353

TgeneAPOD

GO:0006629

lipid metabolic process

19176353

TgeneAPOD

GO:0010642

negative regulation of platelet-derived growth factor receptor signaling pathway

14551159

TgeneAPOD

GO:0042308

negative regulation of protein import into nucleus

14551159

TgeneAPOD

GO:0048662

negative regulation of smooth muscle cell proliferation

14551159

TgeneAPOD

GO:0060588

negative regulation of lipoprotein lipid oxidation

18419796

TgeneAPOD

GO:0071638

negative regulation of monocyte chemotactic protein-1 production

18842892

TgeneAPOD

GO:1900016

negative regulation of cytokine production involved in inflammatory response

18842892

TgeneAPOD

GO:2000405

negative regulation of T cell migration

18842892


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG926842FN1chr2

216269267

-APODchr3

195306296

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000421182ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000357867ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000323926ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000336916ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000354785ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000357009ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000346544ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000345488ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000359671ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000446046ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000443816ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000432072ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000356005ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000490833ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-
intron-3CDSENST00000426059ENST00000343267FN1chr2

216269267

-APODchr3

195306296

-

Top

FusionProtFeatures for FN1_APOD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FN1

P02751

APOD

P05090

APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in thetransport and binding of bilin. Appears to be able to transport avariety of ligands in a number of different contexts.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FN1_APOD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FN1_APOD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FN1_APOD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFN1P02751DB08888OcriplasminFibronectinbiotechapproved
HgeneFN1P02751DB01593ZincFibronectinsmall moleculeapproved|investigational
TgeneAPODP05090DB00162Vitamin AApolipoprotein Dsmall moleculeapproved|nutraceutical|vet_approved

Top

RelatedDiseases for FN1_APOD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFN1C0020538Hypertensive disease2CTD_human;HPO
HgeneFN1C0000786Spontaneous abortion1CTD_human
HgeneFN1C0003504Aortic Valve Insufficiency1CTD_human
HgeneFN1C0007621Neoplastic Cell Transformation1CTD_human
HgeneFN1C0010346Crohn Disease1CTD_human
HgeneFN1C0011849Diabetes Mellitus1CTD_human
HgeneFN1C0011881Diabetic Nephropathy1CTD_human
HgeneFN1C0017636Glioblastoma1CTD_human
HgeneFN1C0017668Focal glomerulosclerosis1CTD_human
HgeneFN1C0024667Animal Mammary Neoplasms1CTD_human
HgeneFN1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneFN1C0027626Neoplasm Invasiveness1CTD_human
HgeneFN1C0034069Pulmonary Fibrosis1CTD_human
HgeneFN1C0036341Schizophrenia1PSYGENET
HgeneFN1C0085762Alcohol abuse1PSYGENET
HgeneFN1C0149721Left Ventricular Hypertrophy1CTD_human
HgeneFN1C0345967Malignant mesothelioma1CTD_human
HgeneFN1C1458155Mammary Neoplasms1CTD_human
HgeneFN1C1866075GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)1UNIPROT
TgeneAPODC0036341Schizophrenia3PSYGENET
TgeneAPODC0005586Bipolar Disorder1PSYGENET
TgeneAPODC0017638Glioma1CTD_human
TgeneAPODC0023186Learning Disorders1CTD_human
TgeneAPODC0086439Hypokinesia1CTD_human
TgeneAPODC0524851Neurodegenerative Disorders1CTD_human