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Fusion gene ID: 13621 |
FusionGeneSummary for FMNL3_TUBA1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FMNL3_TUBA1B | Fusion gene ID: 13621 | Hgene | Tgene | Gene symbol | FMNL3 | TUBA1B | Gene ID | 91010 | 10376 |
| Gene name | formin like 3 | tubulin alpha 1b | |
| Synonyms | FHOD3|FRL2|WBP-3|WBP3 | K-ALPHA-1 | |
| Cytomap | 12q13.12 | 12q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | formin-like protein 3WW domain binding protein 3formin homology 2 domain-containing protein 3 | tubulin alpha-1B chainalpha tubulinalpha-tubulin ubiquitoustubulin K-alpha-1tubulin alpha-ubiquitous chaintubulin, alpha, ubiquitous | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IVF7 | P68363 | |
| Ensembl transtripts involved in fusion gene | ENST00000335154, ENST00000550488, ENST00000352151, ENST00000293590, ENST00000550668, | ENST00000336023, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 8 X 7 X 3=168 |
| # samples | 6 | 9 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FMNL3 [Title/Abstract] AND TUBA1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-14-0817-01A | FMNL3 | chr12 | 50100838 | - | TUBA1B | chr12 | 49523505 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000335154 | ENST00000336023 | FMNL3 | chr12 | 50100838 | - | TUBA1B | chr12 | 49523505 | - |
| In-frame | ENST00000550488 | ENST00000336023 | FMNL3 | chr12 | 50100838 | - | TUBA1B | chr12 | 49523505 | - |
| In-frame | ENST00000352151 | ENST00000336023 | FMNL3 | chr12 | 50100838 | - | TUBA1B | chr12 | 49523505 | - |
| In-frame | ENST00000293590 | ENST00000336023 | FMNL3 | chr12 | 50100838 | - | TUBA1B | chr12 | 49523505 | - |
| intron-3CDS | ENST00000550668 | ENST00000336023 | FMNL3 | chr12 | 50100838 | - | TUBA1B | chr12 | 49523505 | - |
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FusionProtFeatures for FMNL3_TUBA1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FMNL3 | TUBA1B |
| Plays a role in the regulation of cell morphology andcytoskeletal organization. Required in the control of cell shapeand migration. Required for developmental angiogenesis (Bysimilarity). In this process, required for microtubulereorganization and for efficient endothelial cell elongation. Inquiescent endothelial cells, triggers rearrangement of the actincytoskeleton, but does not alter microtubule alignement.{ECO:0000250|UniProtKB:Q6NXC0, ECO:0000269|PubMed:21834987,ECO:0000269|PubMed:22275430}. | Tubulin is the major constituent of microtubules. Itbinds two moles of GTP, one at an exchangeable site on the betachain and one at a non-exchangeable site on the alpha chain. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TUBA1B | chr12:50100838 | chr12:49523505 | ENST00000336023 | - | 0 | 4 | 142_148 | 1 | 452 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000293590 | - | 1 | 26 | 499_548 | 42 | 1029 | Compositional bias | Note=Pro-rich |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000335154 | - | 1 | 26 | 499_548 | 42 | 1028 | Compositional bias | Note=Pro-rich |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000352151 | - | 1 | 25 | 499_548 | 42 | 977 | Compositional bias | Note=Pro-rich |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000293590 | - | 1 | 26 | 26_472 | 42 | 1029 | Domain | GBD/FH3 |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000293590 | - | 1 | 26 | 561_951 | 42 | 1029 | Domain | FH2 |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000293590 | - | 1 | 26 | 986_1018 | 42 | 1029 | Domain | Note=DAD |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000335154 | - | 1 | 26 | 26_472 | 42 | 1028 | Domain | GBD/FH3 |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000335154 | - | 1 | 26 | 561_951 | 42 | 1028 | Domain | FH2 |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000335154 | - | 1 | 26 | 986_1018 | 42 | 1028 | Domain | Note=DAD |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000352151 | - | 1 | 25 | 26_472 | 42 | 977 | Domain | GBD/FH3 |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000352151 | - | 1 | 25 | 561_951 | 42 | 977 | Domain | FH2 |
| Hgene | >FMNL3 | chr12:50100838 | chr12:49523505 | ENST00000352151 | - | 1 | 25 | 986_1018 | 42 | 977 | Domain | Note=DAD |
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FusionGeneSequence for FMNL3_TUBA1B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FMNL3_ENST00000335154_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_493aa MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSF NTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFH SFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNR LISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLY RGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYV >In-frame_FMNL3_ENST00000550488_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_493aa MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSF NTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFH SFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNR LISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLY RGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYV >In-frame_FMNL3_ENST00000352151_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_493aa MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSF NTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFH SFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNR LISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLY RGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYV >In-frame_FMNL3_ENST00000293590_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_493aa MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSF NTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFH SFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNR LISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLY RGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FMNL3_ENST00000335154_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_1479nt ATGGGCAACCTGGAGAGCGCCGAGGGGGTCCCGGGAGAGCCCCCCTCTGTCCCGTTGTTGCTGCCGCCCGGCAAGATGCCGATGCCTGAG CCCTGTGAGCTGGAGGAAAGGTTCGCCCTGGTGCTGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCC TGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGACTCCTTC AACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCACGTGCCCCGGGCTGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGC ACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACC ATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGCAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCAC AGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTC TCCATTTACCCAGCACCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGAT TGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAGCGCCCAACCTACACTAACCTTAACCGC CTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTG GTGCCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCA GAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTAC CGTGGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGCAGCATCCAGTTTGTGGATTGGTGCCCCACT GGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGC AACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTACGTG GGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGATATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCT >In-frame_FMNL3_ENST00000550488_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_1479nt ATGGGCAACCTGGAGAGCGCCGAGGGGGTCCCGGGAGAGCCCCCCTCTGTCCCGTTGTTGCTGCCGCCCGGCAAGATGCCGATGCCTGAG CCCTGTGAGCTGGAGGAAAGGTTCGCCCTGGTGCTGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCC TGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGACTCCTTC AACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCACGTGCCCCGGGCTGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGC ACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACC ATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGCAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCAC AGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTC TCCATTTACCCAGCACCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGAT TGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAGCGCCCAACCTACACTAACCTTAACCGC CTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTG GTGCCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCA GAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTAC CGTGGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGCAGCATCCAGTTTGTGGATTGGTGCCCCACT GGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGC AACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTACGTG GGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGATATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCT >In-frame_FMNL3_ENST00000352151_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_1479nt ATGGGCAACCTGGAGAGCGCCGAGGGGGTCCCGGGAGAGCCCCCCTCTGTCCCGTTGTTGCTGCCGCCCGGCAAGATGCCGATGCCTGAG CCCTGTGAGCTGGAGGAAAGGTTCGCCCTGGTGCTGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCC TGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGACTCCTTC AACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCACGTGCCCCGGGCTGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGC ACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACC ATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGCAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCAC AGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTC TCCATTTACCCAGCACCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGAT TGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAGCGCCCAACCTACACTAACCTTAACCGC CTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTG GTGCCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCA GAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTAC CGTGGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGCAGCATCCAGTTTGTGGATTGGTGCCCCACT GGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGC AACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTACGTG GGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGATATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCT >In-frame_FMNL3_ENST00000293590_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_1479nt ATGGGCAACCTGGAGAGCGCCGAGGGGGTCCCGGGAGAGCCCCCCTCTGTCCCGTTGTTGCTGCCGCCCGGCAAGATGCCGATGCCTGAG CCCTGTGAGCTGGAGGAAAGGTTCGCCCTGGTGCTGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCC TGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGACTCCTTC AACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCACGTGCCCCGGGCTGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGC ACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACC ATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGCAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCAC AGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTC TCCATTTACCCAGCACCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGAT TGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAGCGCCCAACCTACACTAACCTTAACCGC CTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTG GTGCCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCA GAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTAC CGTGGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGCAGCATCCAGTTTGTGGATTGGTGCCCCACT GGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGC AACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTACGTG GGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGATATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FMNL3_ENST00000335154_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_1889nt GAGCCGGCCGCCTCCGTCCGCCTTGCTTCGGTGCGGCTGTCCGCTACGCTGCCTCCGCCCTCGCCGCGCGCCCCCGCCAGCGGGACTCCA GGGAACCCCCGGCGCCCTCGACGGGGCCGAGGAGTCGGGACTCGGGGAGCCGGCGCTGAGGGAGGAGCCTGGTCGGAGCCGCGGAGCCGA AAGCTCCGGAGCGTGGAGGTGGGGGGCCGAGGCCCCTGAGGGGGCCCCGCCGCGATGGGCAACCTGGAGAGCGCCGAGGGGGTCCCGGGA GAGCCCCCCTCTGTCCCGTTGTTGCTGCCGCCCGGCAAGATGCCGATGCCTGAGCCCTGTGAGCTGGAGGAAAGGTTCGCCCTGGTGCTG CGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAG CCCGATGGCCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGACTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCAC GTGCCCCGGGCTGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAG CTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGA ATTCGCAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCC CTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTCTCCATTTACCCAGCACCCCAGGTTTCCACAGCTGTA GTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACAATGAGGCCATCTATGAC ATCTGTCGTAGAAACCTCGATATCGAGCGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCC CTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCCCGCATCCACTTCCCTCTGGCCACA TATGCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAG ATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGTGGTGACGTGGTTCCCAAAGATGTCAATGCTGCC ATTGCCACCATCAAAACCAAGCGCAGCATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACT GTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTG GACCACAAGTTTGACCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCC CGTGAAGATATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTTGAAGGAGAGGGTGAGGAAGAAGGAGAGGAATAC TAATTATCCATTCCTTTTGGCCCTGCAGCATGTCATGCTCCCAGAATTTCAGCTTCAGCTTAACTGACAGACGTTAAAGCTTTCTGGTTA >In-frame_FMNL3_ENST00000550488_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_1695nt GGAGGTGGGGGGCCGAGGCCCCTGAGGGGGCCCCGCCGCGATGGGCAACCTGGAGAGCGCCGAGGGGGTCCCGGGAGAGCCCCCCTCTGT CCCGTTGTTGCTGCCGCCCGGCAAGATGCCGATGCCTGAGCCCTGTGAGCTGGAGGAAAGGTTCGCCCTGGTGCTGCGTGAGTGCATCTC CATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGAT GCCAAGTGACAAGACCATTGGGGGAGGAGATGACTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCACGTGCCCCGGGCTGT GTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAA GGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGCAAGCTGGC TGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACG TCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTCTCCATTTACCCAGCACCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAA CTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAA CCTCGATATCGAGCGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGG AGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCAT CTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGA CCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGTGGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAA AACCAAGCGCAGCATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGG AGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGA CCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGATATGGC TGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTTGAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAATTATCCATTCC TTTTGGCCCTGCAGCATGTCATGCTCCCAGAATTTCAGCTTCAGCTTAACTGACAGACGTTAAAGCTTTCTGGTTAGATTGTTTTCACTT >In-frame_FMNL3_ENST00000352151_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_1868nt CTTGCTTCGGTGCGGCTGTCCGCTACGCTGCCTCCGCCCTCGCCGCGCGCCCCCGCCAGCGGGACTCCAGGGAACCCCCGGCGCCCTCGA CGGGGCCGAGGAGTCGGGACTCGGGGAGCCGGCGCTGAGGGAGGAGCCTGGTCGGAGCCGCGGAGCCGAAAGCTCCGGAGCGTGGAGGTG GGGGGCCGAGGCCCCTGAGGGGGCCCCGCCGCGATGGGCAACCTGGAGAGCGCCGAGGGGGTCCCGGGAGAGCCCCCCTCTGTCCCGTTG TTGCTGCCGCCCGGCAAGATGCCGATGCCTGAGCCCTGTGAGCTGGAGGAAAGGTTCGCCCTGGTGCTGCGTGAGTGCATCTCCATCCAC GTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGT GACAAGACCATTGGGGGAGGAGATGACTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCACGTGCCCCGGGCTGTGTTTGTA GACTTGGAACCCACAGTCATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGAT GCTGCCAATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGAATTCGCAAGCTGGCTGACCAG TGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGTCTCTCA GTTGATTATGGCAAGAAGTCCAAGCTGGAGTTCTCCATTTACCCAGCACCCCAGGTTTCCACAGCTGTAGTTGAGCCCTACAACTCCATC CTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGAT ATCGAGCGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCCCTGAGATTTGATGGAGCCCTG AATGTTGACCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCT GAGAAAGCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAGATGGTGAAATGTGACCCTCGC CATGGTAAATACATGGCTTGCTGCCTGTTGTACCGTGGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAG CGCAGCATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACTGTGGTGCCTGGTGGAGACCTG GCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATG TATGCCAAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCCCGTGAAGATATGGCTGCCCTT GAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTTGAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAATTATCCATTCCTTTTGGC CCTGCAGCATGTCATGCTCCCAGAATTTCAGCTTCAGCTTAACTGACAGACGTTAAAGCTTTCTGGTTAGATTGTTTTCACTTGGTGATC >In-frame_FMNL3_ENST00000293590_chr12_50100838_-_TUBA1B_ENST00000336023_chr12_49523505_-_1889nt GAGCCGGCCGCCTCCGTCCGCCTTGCTTCGGTGCGGCTGTCCGCTACGCTGCCTCCGCCCTCGCCGCGCGCCCCCGCCAGCGGGACTCCA GGGAACCCCCGGCGCCCTCGACGGGGCCGAGGAGTCGGGACTCGGGGAGCCGGCGCTGAGGGAGGAGCCTGGTCGGAGCCGCGGAGCCGA AAGCTCCGGAGCGTGGAGGTGGGGGGCCGAGGCCCCTGAGGGGGCCCCGCCGCGATGGGCAACCTGGAGAGCGCCGAGGGGGTCCCGGGA GAGCCCCCCTCTGTCCCGTTGTTGCTGCCGCCCGGCAAGATGCCGATGCCTGAGCCCTGTGAGCTGGAGGAAAGGTTCGCCCTGGTGCTG CGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGCTGGGAGCTCTACTGCCTGGAACACGGCATCCAG CCCGATGGCCAGATGCCAAGTGACAAGACCATTGGGGGAGGAGATGACTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAGCAC GTGCCCCGGGCTGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACTGGCACCTACCGCCAGCTCTTCCACCCTGAGCAG CTCATCACAGGCAAGGAAGATGCTGCCAATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGACCGA ATTCGCAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGCTTTGGTGGGGGAACTGGTTCTGGGTTCACCTCC CTGCTCATGGAACGTCTCTCAGTTGATTATGGCAAGAAGTCCAAGCTGGAGTTCTCCATTTACCCAGCACCCCAGGTTTCCACAGCTGTA GTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGTGCCTTCATGGTAGACAATGAGGCCATCTATGAC ATCTGTCGTAGAAACCTCGATATCGAGCGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCTTCC CTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTGCCCTACCCCCGCATCCACTTCCCTCTGGCCACA TATGCCCCTGTCATCTCTGCTGAGAAAGCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAACCAG ATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGTGGTGACGTGGTTCCCAAAGATGTCAATGCTGCC ATTGCCACCATCAAAACCAAGCGCAGCATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCCACT GTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAACACCACAGCCATTGCTGAGGCCTGGGCTCGCCTG GACCACAAGTTTGACCTGATGTATGCCAAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAGGCC CGTGAAGATATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTTGAAGGAGAGGGTGAGGAAGAAGGAGAGGAATAC TAATTATCCATTCCTTTTGGCCCTGCAGCATGTCATGCTCCCAGAATTTCAGCTTCAGCTTAACTGACAGACGTTAAAGCTTTCTGGTTA |
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FusionGenePPI for FMNL3_TUBA1B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FMNL3 | PRPF40A, APP, MMS19, FAM96B, CIAO1, NTRK1 | TUBA1B | RBX1, CUL4A, PIK3R1, POLH, ZMYM2, CD247, ZAP70, INO80, RICTOR, PSMA3, TOM1L1, SP1, KCND3, INPPL1, UBASH3B, SHC1, SNCA, SLC6A3, TUBB1, A2M, PSEN1, TUBA1A, TUBA1C, TUBB2A, CCT6A, TUBB4B, TUBB6, TUBB3, TUBB2B, TUBB, LAMP2, RPL5, PSMD1, PSMC4, RPLP0P6, SSBP1, SNRNP200, U2AF1, SF3B1, LTV1, RPL18, RCN1, LGALS2, LTA, VDAC1, CCT2, FN1, VCAM1, IQCB1, MAP1LC3A, UBL4A, GZMM, PAN2, CD81, IGSF8, HDAC6, TERT, SLX1B, TMEM253, SMAD2, FBXO6, TARDBP, ASB17, ZBTB1, AP2M1, ERRFI1, LGR4, CHORDC1, FKBPL, MAPT, CEP250, CEP76, TUBGCP2, EML1, FUS, AGTRAP, MTCL1, CUL7, OBSL1, EZH2, EED, RNF2, FAF2, SUMO2, RPS6KB2, PTEN, SRPK2, OFD1, XPO1, MYO19, ARMC6, ASPM, ID2, GAN, SKI, RANBP9, PIWIL1, STMN1, MID1, MID2, SNW1, CDC5L, ESRRB, ERBB3, CDC37, FBXW7, MTMR2, PPP3CA, TCP11L2, TXNDC9, DLGAP5, CCT6B, CCT7, CCT4, MICU1, HYAL1, TCP1, CCT3, C17orf89, CCND2, HEY1, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FMNL3_TUBA1B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FMNL3_TUBA1B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TUBA1B | C0029456 | Osteoporosis | 1 | CTD_human |
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