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Fusion gene ID: 13613 |
FusionGeneSummary for FMNL2_SEC24C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FMNL2_SEC24C | Fusion gene ID: 13613 | Hgene | Tgene | Gene symbol | FMNL2 | SEC24C | Gene ID | 114793 | 9632 |
| Gene name | formin like 2 | SEC24 homolog C, COPII coat complex component | |
| Synonyms | FHOD2 | - | |
| Cytomap | 2q23.3 | 10q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | formin-like protein 2formin homology 2 domain containing 2formin homology 2 domain-containing protein 2 | protein transport protein Sec24CSEC24 family, member CSEC24 related gene family, member CSEC24-related protein C | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q96PY5 | P53992 | |
| Ensembl transtripts involved in fusion gene | ENST00000288670, ENST00000475377, ENST00000497192, | ENST00000535742, ENST00000546025, ENST00000345254, ENST00000540668, ENST00000339365, ENST00000411652, ENST00000496827, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 5 X 5 X 2=50 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
| Context | PubMed: FMNL2 [Title/Abstract] AND SEC24C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SEC24C | GO:0090110 | cargo loading into COPII-coated vesicle | 17499046|18843296 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG998981 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000288670 | ENST00000535742 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000288670 | ENST00000546025 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000288670 | ENST00000345254 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000288670 | ENST00000540668 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000288670 | ENST00000339365 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000288670 | ENST00000411652 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000288670 | ENST00000496827 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000475377 | ENST00000535742 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000475377 | ENST00000546025 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000475377 | ENST00000345254 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000475377 | ENST00000540668 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000475377 | ENST00000339365 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000475377 | ENST00000411652 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000475377 | ENST00000496827 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000497192 | ENST00000535742 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000497192 | ENST00000546025 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000497192 | ENST00000345254 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000497192 | ENST00000540668 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000497192 | ENST00000339365 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000497192 | ENST00000411652 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
| intron-intron | ENST00000497192 | ENST00000496827 | FMNL2 | chr2 | 153300686 | + | SEC24C | chr10 | 75526109 | + |
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FusionProtFeatures for FMNL2_SEC24C |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FMNL2 | SEC24C |
| Plays a role in the regulation of cell morphology andcytoskeletal organization. Required in the cortical actin filamentdynamics. {ECO:0000269|PubMed:21834987}. | Component of the coat protein complex II (COPII) whichpromotes the formation of transport vesicles from the endoplasmicreticulum (ER). The coat has two main functions, the physicaldeformation of the endoplasmic reticulum membrane into vesiclesand the selection of cargo molecules for their transport to theGolgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296,PubMed:20427317). Plays a central role in cargo selection withinthe COPII complex and together with SEC24D may have a differentspecificity compared to SEC24A and SEC24B (PubMed:17499046,PubMed:20427317, PubMed:18843296). May more specifically packageGPI-anchored proteins through the cargo receptor TMED10(PubMed:20427317). May also be specific for IxM motif-containingcargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).{ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046,ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FMNL2_SEC24C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FMNL2_SEC24C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FMNL2_SEC24C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FMNL2_SEC24C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SEC24C | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | SEC24C | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | SEC24C | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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