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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13611

FusionGeneSummary for FMNL2_FMNL2

check button Fusion gene summary
Fusion gene informationFusion gene name: FMNL2_FMNL2
Fusion gene ID: 13611
HgeneTgene
Gene symbol

FMNL2

FMNL2

Gene ID

114793

114793

Gene nameformin like 2formin like 2
SynonymsFHOD2FHOD2
Cytomap

2q23.3

2q23.3

Type of geneprotein-codingprotein-coding
Descriptionformin-like protein 2formin homology 2 domain containing 2formin homology 2 domain-containing protein 2formin-like protein 2formin homology 2 domain containing 2formin homology 2 domain-containing protein 2
Modification date2018052220180522
UniProtAcc

Q96PY5

Q96PY5

Ensembl transtripts involved in fusion geneENST00000288670, ENST00000475377, 
ENST00000497192, 
ENST00000288670, 
ENST00000475377, ENST00000497192, 
Fusion gene scores* DoF score6 X 6 X 3=1088 X 6 X 6=288
# samples 68
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FMNL2 [Title/Abstract] AND FMNL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG698704FMNL2chr2

153330366

+FMNL2chr2

153287359

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000288670ENST00000288670FMNL2chr2

153330366

+FMNL2chr2

153287359

+
intron-intronENST00000288670ENST00000475377FMNL2chr2

153330366

+FMNL2chr2

153287359

+
intron-intronENST00000288670ENST00000497192FMNL2chr2

153330366

+FMNL2chr2

153287359

+
intron-intronENST00000475377ENST00000288670FMNL2chr2

153330366

+FMNL2chr2

153287359

+
intron-intronENST00000475377ENST00000475377FMNL2chr2

153330366

+FMNL2chr2

153287359

+
intron-intronENST00000475377ENST00000497192FMNL2chr2

153330366

+FMNL2chr2

153287359

+
intron-intronENST00000497192ENST00000288670FMNL2chr2

153330366

+FMNL2chr2

153287359

+
intron-intronENST00000497192ENST00000475377FMNL2chr2

153330366

+FMNL2chr2

153287359

+
intron-intronENST00000497192ENST00000497192FMNL2chr2

153330366

+FMNL2chr2

153287359

+

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FusionProtFeatures for FMNL2_FMNL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FMNL2

Q96PY5

FMNL2

Q96PY5

Plays a role in the regulation of cell morphology andcytoskeletal organization. Required in the cortical actin filamentdynamics. {ECO:0000269|PubMed:21834987}. Plays a role in the regulation of cell morphology andcytoskeletal organization. Required in the cortical actin filamentdynamics. {ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FMNL2_FMNL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FMNL2_FMNL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FMNL2_FMNL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FMNL2_FMNL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource