FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13600

FusionGeneSummary for FMN1_COL22A1

check button Fusion gene summary
Fusion gene informationFusion gene name: FMN1_COL22A1
Fusion gene ID: 13600
HgeneTgene
Gene symbol

FMN1

COL22A1

Gene ID

342184

169044

Gene nameformin 1collagen type XXII alpha 1 chain
SynonymsFMN|LD-
Cytomap

15q13.3

8q24.23-q24.3

Type of geneprotein-codingprotein-coding
Descriptionformin-1formin (limb deformity)limb deformity protein homologcollagen alpha-1(XXII) chain
Modification date2018051920180523
UniProtAcc

Q68DA7

Q8NFW1

Ensembl transtripts involved in fusion geneENST00000334528, ENST00000561249, 
ENST00000559047, ENST00000558197, 
ENST00000559150, ENST00000320930, 
ENST00000341807, ENST00000303045, 
ENST00000435777, 
Fusion gene scores* DoF score9 X 6 X 5=2708 X 7 X 5=280
# samples 97
** MAII scorelog2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/280*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FMN1 [Title/Abstract] AND COL22A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-A6-6782-01AFMN1chr15

33256308

-COL22A1chr8

139672723

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000334528ENST00000341807FMN1chr15

33256308

-COL22A1chr8

139672723

-
5CDS-5UTRENST00000334528ENST00000303045FMN1chr15

33256308

-COL22A1chr8

139672723

-
5CDS-5UTRENST00000334528ENST00000435777FMN1chr15

33256308

-COL22A1chr8

139672723

-
5CDS-5UTRENST00000561249ENST00000341807FMN1chr15

33256308

-COL22A1chr8

139672723

-
5CDS-5UTRENST00000561249ENST00000303045FMN1chr15

33256308

-COL22A1chr8

139672723

-
5CDS-5UTRENST00000561249ENST00000435777FMN1chr15

33256308

-COL22A1chr8

139672723

-
5CDS-5UTRENST00000559047ENST00000341807FMN1chr15

33256308

-COL22A1chr8

139672723

-
5CDS-5UTRENST00000559047ENST00000303045FMN1chr15

33256308

-COL22A1chr8

139672723

-
5CDS-5UTRENST00000559047ENST00000435777FMN1chr15

33256308

-COL22A1chr8

139672723

-
intron-5UTRENST00000558197ENST00000341807FMN1chr15

33256308

-COL22A1chr8

139672723

-
intron-5UTRENST00000558197ENST00000303045FMN1chr15

33256308

-COL22A1chr8

139672723

-
intron-5UTRENST00000558197ENST00000435777FMN1chr15

33256308

-COL22A1chr8

139672723

-
intron-5UTRENST00000559150ENST00000341807FMN1chr15

33256308

-COL22A1chr8

139672723

-
intron-5UTRENST00000559150ENST00000303045FMN1chr15

33256308

-COL22A1chr8

139672723

-
intron-5UTRENST00000559150ENST00000435777FMN1chr15

33256308

-COL22A1chr8

139672723

-
intron-5UTRENST00000320930ENST00000341807FMN1chr15

33256308

-COL22A1chr8

139672723

-
intron-5UTRENST00000320930ENST00000303045FMN1chr15

33256308

-COL22A1chr8

139672723

-
intron-5UTRENST00000320930ENST00000435777FMN1chr15

33256308

-COL22A1chr8

139672723

-

Top

FusionProtFeatures for FMN1_COL22A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FMN1

Q68DA7

COL22A1

Q8NFW1

Plays a role in the formation of adherens junction andthe polymerization of linear actin cables. {ECO:0000250}. Acts as a cell adhesion ligand for skin epithelial cellsand fibroblasts.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FMN1_COL22A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FMN1_COL22A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FMN1PRPF40A, NUP85, LLGL2, CDH1, CYP2S1, NAPGCOL22A1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FMN1_COL22A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FMN1_COL22A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCOL22A1C0149925Small cell carcinoma of lung1CTD_human