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Fusion gene ID: 13593 |
FusionGeneSummary for FLVCR2_BATF |
Fusion gene summary |
Fusion gene information | Fusion gene name: FLVCR2_BATF | Fusion gene ID: 13593 | Hgene | Tgene | Gene symbol | FLVCR2 | BATF | Gene ID | 55640 | 10538 |
Gene name | feline leukemia virus subgroup C cellular receptor family member 2 | basic leucine zipper ATF-like transcription factor | |
Synonyms | C14orf58|CCT|EPV|FLVCRL14q|MFSD7C|PVHH | B-ATF|BATF1|SFA-2|SFA2 | |
Cytomap | 14q24.3 | 14q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | feline leukemia virus subgroup C receptor-related protein 2calcium-chelate transporter | basic leucine zipper transcriptional factor ATF-likeB-cell-activating transcription factorSF-HT-activated gene 2 proteinactivating transcription factor Bbasic leucine zipper transcription factor, ATF-like | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UPI3 | Q16520 | |
Ensembl transtripts involved in fusion gene | ENST00000238667, ENST00000539311, ENST00000556241, ENST00000553587, ENST00000556856, ENST00000555027, | ENST00000286639, ENST00000555795, ENST00000555504, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 1 X 2=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: FLVCR2 [Title/Abstract] AND BATF [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ACC | TCGA-OR-A5J7-01A | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000238667 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
5CDS-3UTR | ENST00000238667 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
5CDS-intron | ENST00000238667 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-3CDS | ENST00000539311 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-3UTR | ENST00000539311 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-intron | ENST00000539311 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-3CDS | ENST00000556241 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-3UTR | ENST00000556241 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-intron | ENST00000556241 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-3CDS | ENST00000553587 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-3UTR | ENST00000553587 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-intron | ENST00000553587 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-3CDS | ENST00000556856 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-3UTR | ENST00000556856 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-intron | ENST00000556856 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-3CDS | ENST00000555027 | ENST00000286639 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-3UTR | ENST00000555027 | ENST00000555795 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
intron-intron | ENST00000555027 | ENST00000555504 | FLVCR2 | chr14 | 76045984 | + | BATF | chr14 | 76012805 | + |
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FusionProtFeatures for FLVCR2_BATF |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FLVCR2 | BATF |
Acts as an importer of heme. Also acts as a transporterfor a calcium-chelator complex, important for growth and calciummetabolism. {ECO:0000269|PubMed:20823265}. | AP-1 family transcription factor that controls thedifferentiation of lineage-specific cells in the immune system:specifically mediates the differentiation of T-helper 17 cells(Th17), follicular T-helper cells (TfH), CD8(+) dendritic cellsand class-switch recombination (CSR) in B-cells. Acts via theformation of a heterodimer with JUNB that recognizes and binds DNAsequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms acomplex with IRF4 (or IRF8) in immune cells, leading torecognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding ofBATF and IRF4 (or IRF8) and activation of genes. Controlsdifferentiation of T-helper cells producing interleukin-17 (Th17cells) by binding to Th17-associated gene promoters: regulatesexpression of the transcription factor RORC itself and RORC targetgenes such as IL17 (IL17A or IL17B). Also involved indifferentiation of follicular T-helper cells (TfH) by directingexpression of BCL6 and MAF. In B-cells, involved in class-switchrecombination (CSR) by controlling the expression of both AICDAand of germline transcripts of the intervening heavy-chain regionand constant heavy-chain region (I(H)-C(H)). Following infection,can participate in CD8(+) dendritic cell differentiation viainteraction with IRF4 and IRF8 to mediate cooperative geneactivation. Regulates effector CD8(+) T-cell differentiation byregulating expression of SIRT1. Following DNA damage, part of adifferentiation checkpoint that limits self-renewal ofhematopoietic stem cells (HSCs): up-regulated by STAT3, leading todifferentiation of HSCs, thereby restricting self-renewal of HSCs(By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FLVCR2_BATF |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FLVCR2_BATF |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FLVCR2 | SHMT2, NXF1, EPN1 | BATF | SNAPC5, DDIT3, IFI35, JUNB, IRF4, BATF3, BATF, ATF3, ATF4, DBP, ATF2, CEBPE, CEBPA, CEBPG, JUN, EPAS1, NFIL3, KDM1A, GOPC |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FLVCR2_BATF |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FLVCR2_BATF |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FLVCR2 | C1856972 | Encephaloclastic Proliferative Vasculopathy | 3 | CTD_human;UNIPROT |