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Fusion gene ID: 13582 |
FusionGeneSummary for FLOT2_FURIN |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FLOT2_FURIN | Fusion gene ID: 13582 | Hgene | Tgene | Gene symbol | FLOT2 | FURIN | Gene ID | 2319 | 5045 |
| Gene name | flotillin 2 | furin, paired basic amino acid cleaving enzyme | |
| Synonyms | ECS-1|ECS1|ESA|ESA1|M17S1 | FUR|PACE|PCSK3|SPC1 | |
| Cytomap | 17q11.2 | 15q26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | flotillin-2Flotillin 2 (epidermal surface antigen 1)epidermal surface antigenmembrane component chromosome 17 surface marker 1membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1) | furinFES upstream regionFURIN/ADAMTS1 fusiondibasic processing enzymefurin, membrane associated receptor proteinpaired basic amino acid residue-cleaving enzymeproprotein convertase subtilisin/kexin type 3 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q14254 | P09958 | |
| Ensembl transtripts involved in fusion gene | ENST00000394906, ENST00000394908, ENST00000585169, ENST00000577789, | ENST00000268171, | |
| Fusion gene scores | * DoF score | 8 X 5 X 4=160 | 5 X 6 X 1=30 |
| # samples | 9 | 10 | |
| ** MAII score | log2(9/160*10)=-0.830074998557688 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/30*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FLOT2 [Title/Abstract] AND FURIN [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FURIN | GO:0006465 | signal peptide processing | 16912035 |
| Tgene | FURIN | GO:0016485 | protein processing | 9242664|10526337|10567353|14744861|15606899|17938254 |
| Tgene | FURIN | GO:0016486 | peptide hormone processing | 9242664 |
| Tgene | FURIN | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process | 16912035 |
| Tgene | FURIN | GO:0032902 | nerve growth factor production | 8615794 |
| Tgene | FURIN | GO:0032904 | negative regulation of nerve growth factor production | 10567353 |
| Tgene | FURIN | GO:0032940 | secretion by cell | 8615794 |
| Tgene | FURIN | GO:0043043 | peptide biosynthetic process | 8262946 |
| Tgene | FURIN | GO:0052548 | regulation of endopeptidase activity | 14744861 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CK822851 | FLOT2 | chr17 | 27207151 | - | FURIN | chr15 | 91424801 | + | ||
| ChiTaRS3.1 | BQ102242 | FLOT2 | chr17 | 27207151 | - | FURIN | chr15 | 91424801 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000394906 | ENST00000268171 | FLOT2 | chr17 | 27207151 | - | FURIN | chr15 | 91424801 | + |
| intron-3CDS | ENST00000394908 | ENST00000268171 | FLOT2 | chr17 | 27207151 | - | FURIN | chr15 | 91424801 | + |
| intron-3CDS | ENST00000585169 | ENST00000268171 | FLOT2 | chr17 | 27207151 | - | FURIN | chr15 | 91424801 | + |
| intron-3CDS | ENST00000577789 | ENST00000268171 | FLOT2 | chr17 | 27207151 | - | FURIN | chr15 | 91424801 | + |
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FusionProtFeatures for FLOT2_FURIN |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FLOT2 | FURIN |
| May act as a scaffolding protein within caveolarmembranes, functionally participating in formation of caveolae orcaveolae-like vesicles. May be involved in epidermal cell adhesionand epidermal structure and function. | Furin is likely to represent the ubiquitous endoproteaseactivity within constitutive secretory pathways and capable ofcleavage at the RX(K/R)R consensus motif.{ECO:0000269|PubMed:11799113, ECO:0000269|PubMed:1629222,ECO:0000269|PubMed:1713771, ECO:0000269|PubMed:2251280,ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265,ECO:0000269|PubMed:7592877, ECO:0000269|PubMed:7690548,ECO:0000269|PubMed:9130696}. (Microbial infection) Probably cleaves and activatesanthrax and diphtheria toxins. (Microbial infection) Required for H7N1 and H5N1influenza virus infection probably by cleaving hemagglutinin.{ECO:0000269|PubMed:25974265}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FLOT2_FURIN |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FLOT2_FURIN |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FLOT2_FURIN |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | FURIN | P09958 | DB04951 | Pirfenidone | Furin | small molecule | approved|investigational |
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RelatedDiseases for FLOT2_FURIN |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FURIN | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
| Tgene | FURIN | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
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