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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13562

FusionGeneSummary for FLNA_EIF2AK2

check button Fusion gene summary
Fusion gene informationFusion gene name: FLNA_EIF2AK2
Fusion gene ID: 13562
HgeneTgene
Gene symbol

FLNA

EIF2AK2

Gene ID

2316

5610

Gene namefilamin Aeukaryotic translation initiation factor 2 alpha kinase 2
SynonymsABP-280|ABPX|CSBS|CVD1|FGS2|FLN|FLN-A|FLN1|FMD|MNS|NHBP|OPD|OPD1|OPD2|XLVD|XMVDEIF2AK1|PKR|PPP1R83|PRKR
Cytomap

Xq28

2p22.2

Type of geneprotein-codingprotein-coding
Descriptionfilamin-Aactin binding protein 280alpha-filaminendothelial actin-binding proteinfilamin A, alphafilamin-1non-muscle filamininterferon-induced, double-stranded RNA-activated protein kinaseP1/eIF-2A protein kinasedouble stranded RNA activated protein kinaseeIF-2A protein kinase 2interferon-inducible elF2alpha kinasep68 kinaseprotein kinase Rprotein kinase, interferon-ind
Modification date2018052320180523
UniProtAcc

P21333

P19525

Ensembl transtripts involved in fusion geneENST00000360319, ENST00000422373, 
ENST00000369850, ENST00000369856, 
ENST00000344736, ENST00000498491, 
ENST00000233057, ENST00000395127, 
ENST00000405334, 
Fusion gene scores* DoF score18 X 21 X 7=264634 X 1 X 15=510
# samples 2534
** MAII scorelog2(25/2646*10)=-3.40381306161659
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(34/510*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FLNA [Title/Abstract] AND EIF2AK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFLNA

GO:0016479

negative regulation of transcription by RNA polymerase I

22307607

HgeneFLNA

GO:0030334

regulation of cell migration

16291724

HgeneFLNA

GO:0031532

actin cytoskeleton reorganization

10051605

HgeneFLNA

GO:0034394

protein localization to cell surface

18322202

HgeneFLNA

GO:0043113

receptor clustering

10692483

HgeneFLNA

GO:0043433

negative regulation of DNA binding transcription factor activity

15684392

HgeneFLNA

GO:0044319

wound healing, spreading of cells

16291724

HgeneFLNA

GO:0045184

establishment of protein localization

18322202

HgeneFLNA

GO:0051764

actin crosslink formation

10051605

HgeneFLNA

GO:0072659

protein localization to plasma membrane

24951510

HgeneFLNA

GO:0090307

mitotic spindle assembly

18548008

HgeneFLNA

GO:1901381

positive regulation of potassium ion transmembrane transport

24951510

TgeneEIF2AK2

GO:0006468

protein phosphorylation

19189853

TgeneEIF2AK2

GO:0017148

negative regulation of translation

12882984

TgeneEIF2AK2

GO:0035455

response to interferon-alpha

19840259

TgeneEIF2AK2

GO:0046777

protein autophosphorylation

22801494

TgeneEIF2AK2

GO:0051092

positive regulation of NF-kappaB transcription factor activity

15121867


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-A44T-01AFLNAchrX

153576900

-EIF2AK2chr2

37342384

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000360319ENST00000233057FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000360319ENST00000395127FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000360319ENST00000405334FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
5CDS-intronENST00000422373ENST00000233057FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
5CDS-intronENST00000422373ENST00000395127FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
5CDS-intronENST00000422373ENST00000405334FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000369850ENST00000233057FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000369850ENST00000395127FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000369850ENST00000405334FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000369856ENST00000233057FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000369856ENST00000395127FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000369856ENST00000405334FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000344736ENST00000233057FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000344736ENST00000395127FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000344736ENST00000405334FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000498491ENST00000233057FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000498491ENST00000395127FLNAchrX

153576900

-EIF2AK2chr2

37342384

-
intron-intronENST00000498491ENST00000405334FLNAchrX

153576900

-EIF2AK2chr2

37342384

-

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FusionProtFeatures for FLNA_EIF2AK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLNA

P21333

EIF2AK2

P19525

Promotes orthogonal branching of actin filaments andlinks actin filaments to membrane glycoproteins. Anchors varioustransmembrane proteins to the actin cytoskeleton and serves as ascaffold for a wide range of cytoplasmic signaling proteins.Interaction with FLNA may allow neuroblast migration from theventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directsits intracellular trafficking (By similarity). Involved inciliogenesis. Plays a role in cell-cell contacts and adherensjunctions during the development of blood vessels, heart and brainorgans. Plays a role in platelets morphology through interactionwith SYK that regulates ITAM- and ITAM-like-containing receptorsignaling, resulting in by platelet cytoskeleton organizationmaintenance (By similarity). {ECO:0000250,ECO:0000250|UniProtKB:Q8BTM8, ECO:0000269|PubMed:22121117}. IFN-induced dsRNA-dependent serine/threonine-proteinkinase which plays a key role in the innate immune response toviral infection and is also involved in the regulation of signaltransduction, apoptosis, cell proliferation and differentiation.Exerts its antiviral activity on a wide range of DNA and RNAviruses including hepatitis C virus (HCV), hepatitis B virus(HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1).Inhibits viral replication via phosphorylation of the alphasubunit of eukaryotic initiation factor 2 (EIF2S1), thisphosphorylation impairs the recycling of EIF2S1 between successiverounds of initiation leading to inhibition of translation whicheventually results in shutdown of cellular and viral proteinsynthesis. Also phosphorylates other substrates includingp53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral proteinUS11. In addition to serine/threonine-protein kinase activity,also has tyrosine-protein kinase activity and phosphorylates CDK1at 'Tyr-4' upon DNA damage, facilitating its ubiquitination andproteosomal degradation. Either as an adapter protein and/or viaits kinase activity, can regulate various signaling pathways (p38MAP kinase, NF-kappa-B and insulin signaling pathways) andtranscription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved inthe expression of genes encoding proinflammatory cytokines andIFNs. Activates the NF-kappa-B pathway via interaction with IKBKBand TRAF family of proteins and activates the p38 MAP kinasepathway via interaction with MAP2K6. Can act as both a positiveand negative regulator of the insulin signaling pathway (ISP).Negatively regulates ISP by inducing the inhibitoryphosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5Awhich activates FOXO1, which in turn up-regulates the expressionof insulin receptor substrate 2 (IRS2). Can regulate NLRP3inflammasome assembly and the activation of NLRP3, NLRP1, AIM2 andNLRC4 inflammasomes. Can trigger apoptosis via FADD-mediatedactivation of CASP8. Plays a role in the regulation of thecytoskeleton by binding to gelsolin (GSN), sequestering theprotein in an inactive conformation away from actin.{ECO:0000269|PubMed:10848580, ECO:0000269|PubMed:11836380,ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15229216,ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:19189853,ECO:0000269|PubMed:19229320, ECO:0000269|PubMed:19507191,ECO:0000269|PubMed:19840259, ECO:0000269|PubMed:20171114,ECO:0000269|PubMed:20395957, ECO:0000269|PubMed:20685959,ECO:0000269|PubMed:21072047, ECO:0000269|PubMed:21123651,ECO:0000269|PubMed:21710204, ECO:0000269|PubMed:22214662,ECO:0000269|PubMed:22381929, ECO:0000269|PubMed:22801494,ECO:0000269|PubMed:22948139, ECO:0000269|PubMed:23084476,ECO:0000269|PubMed:23115276, ECO:0000269|PubMed:23229543,ECO:0000269|PubMed:23372823, ECO:0000269|PubMed:23399035}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FLNA_EIF2AK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FLNA_EIF2AK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FLNADRD3, ITGB1, VHL, CMIP, AR, TRIO, CASR, BRCA2, FBLIM1, NPHP1, FLNB, ITGB3, ITGB6, DCN, DRD2, F3, ITGB7, TRAF2, RALA, GP1BA, SH2B3, FILIP1, OTUD1, OTUD5, USP45, G3BP1, DMWD, CAMKK2, MAPK14, SRC, APC, BANF1, AGO3, TJP1, HDAC5, SVIL, ARRB1, ARRB2, SIRT7, ISG15, ASB2, CUL3, CDK2, LMNA, SHBG, KCND2, KCNE4, MYH9, LGALS1, ILF2, DBN1, CPLX1, GNN, RANBP2, SRRM2, SRSF11, RBM39, IKBIP, TRA2B, ESR1, BRCA1, ECT2, LIG4, MDC1, TP53BP1, TSGA10, IKBKAP, SMURF1, HSP90AA1, HSP90AB1, BTK, MYC, FN1, VCAM1, IQCB1, GRB2, MTNR1A, SYNPO2, SMAD3, ITGA4, MYBL2, USP19, PAN2, IGSF8, CD81, ICAM1, BSG, NPM1, ADRB2, HNRNPD, AKAP12, DYNC1H1, DYNC1LI1, DYNC1LI2, RPS23, RPA1, RPA2, RPA3, ZBTB1, STAU1, TRIM55, TP53, FABP1, REL, TCF4, HSPB7, ADAMTSL4, LGALS14, KLHL12, FAM101A, CUL7, OBSL1, CCDC8, TXNDC16, FOXRED2, SIRT6, ABCE1, FBXW11, CARD8, FAM90A1, HNRNPA1, ACAD10, DNAAF5, NMD3, PDIA3, PFDN2, PFDN4, PFDN5, VBP1, TDRD15, NTRK1, SELE, HIST1H3E, PPME1, ACTB, ACTG1, ACTN4, AP2A1, AP2B1, ANXA2, CALM1, CAPZA1, CAPZA2, CAPZB, CD44, CD59, CFL1, CFL2, AP2M1, CLTA, CLTB, CLTC, CPM, DAB2, DAPK3, DSG2, CTTN, EPS15, FLII, MYH11, MYO1C, PPP1CB, IQGAP1, PDLIM7, SYNPO, MAPRE1, LIMA1, ANLN, MYO5C, MYO19, MYO18A, FLOT2, GNAI1, GNAS, GNB2, GSN, HMGB2, ITPR3, JUP, ABLIM1, MYO1B, MYO1E, MYO5A, MYO6, PPP1R12A, PALM, PIK3C2A, PLEC, PPP1CA, PPP1CC, TWF1, S100A10, SEC13, FSCN1, UAP1, SPTAN1, SPTBN1, SPTBN2, SSFA2, TMOD1, TPM1, TPM2, TPM4, CORO2A, LUZP1, SORBS2, CLINT1, ARHGAP11A, WDR1, ARPC4, ARPC3, ARPC1B, ACTR3, ACTR2, FLOT1, BASP1, AKAP2, CEP162, PALLD, MPRIP, COBL, CORO1C, PLEKHG3, RAI14, TES, ZBTB20, TMOD3, BMP2K, GNG12, CORO1B, KIAA1211, ARHGAP21, AFAP1, INF2, CYBRD1, ARPC5L, KCTD10, ANTXR1, PPP1R9B, STON2, DIXDC1, SSH2, PHLDB2, NEXN, SPECC1, MISP, CHMP4B, PPP1R18, TPRN, CAMK2G, CRK, MAP3K3, CRY1, CRY2, ALKBH3, MCM2, MCM5, NLGN3, ARFGEF2, CDC73, CDH1, CAPN6, APOH, RAB8B, MTNR1B, CYLD, MCPH1, HEY1, TXNIPEIF2AK2DBNL, FANCC, PRKRIP1, STAT1, PPP1CA, PRKRA, TP53, ILF3, METAP2, DNAJC3, PPP2R5A, ILF2, EIF2AK2, TARBP2, MAP3K5, CHUK, IKBKB, HIST2H2AC, PDGFRB, STAT3, EIF2S1, DHX58, CCNA2, DHX9, DICER1, EDC4, STAU2, ZNF346, STAU1, CCDC124, CDK3, EBNA1BP2, FARSB, FTSJ3, GLTSCR2, IFRD1, NOC3L, PPP1CC, DHX30, EIF6, FARSA, GNL3, GTPBP4, HIST1H1C, HNRNPC, HNRNPCL1, KCTD17, LYAR, MOV10, NOP2, PABPC4, PURA, SSB, TOLLIP, TOP1, XRN2, MAVS, HDGF, ELAVL1, MAP3K7, ISG15, CUL3, CAND1, ATP6V1F, JAK1, TYK2, HSP90AA1, IL7R, NPM1, EIF2A, PTGES3, HECW2, IGF2BP3, IGF2BP2, EGFR, TRAF5, TRAF6, TRAF2, CYP1A1, NTRK1, IFI16, SCARB2, RPL10, ELMSAN1, CDCA5, CHMP4B, MACROD1, MCM2, CDC37, PRKRIR, HIST1H2AB, MECP2, GPX7, IQCF1, PTEN, RPL6, RPLP0, RPS2, RPS3A, LMNA, COX15, DLD, DLST


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FLNA_EIF2AK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFLNAP21333DB11638ArtenimolFilamin-Asmall moleculeapproved|investigational

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RelatedDiseases for FLNA_EIF2AK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFLNAC1848213Periventricular Heterotopia, X-Linked6UNIPROT
HgeneFLNAC0265251Oto-Palato-digital syndrome type 14CTD_human;ORPHANET;UNIPROT
HgeneFLNAC0265293Frontometaphyseal dysplasia4CTD_human;ORPHANET;UNIPROT
HgeneFLNAC1844696OTOPALATODIGITAL SYNDROME, TYPE II4CTD_human;ORPHANET;UNIPROT
HgeneFLNAC0025237Melnick-Needles Syndrome3ORPHANET;UNIPROT
HgeneFLNAC1868720Periventricular Nodular Heterotopia2CTD_human;ORPHANET
HgeneFLNAC0010701Phyllodes Tumor1CTD_human
HgeneFLNAC0014544Epilepsy1CTD_human;HPO
HgeneFLNAC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFLNAC0029422Osteochondrodysplasias1CTD_human;HPO
HgeneFLNAC0220769FG syndrome1CTD_human
HgeneFLNAC0262436Cardiac valvular dysplasia, X-linked1CTD_human;UNIPROT
HgeneFLNAC1458155Mammary Neoplasms1CTD_human
HgeneFLNAC1845235Heterotopia, Periventricular, Ehlers-Danlos Variant1CTD_human
HgeneFLNAC1845902FG SYNDROME 21UNIPROT
TgeneEIF2AK2C0021400Influenza1CTD_human
TgeneEIF2AK2C0033578Prostatic Neoplasms1CTD_human
TgeneEIF2AK2C0038220Status Epilepticus1CTD_human