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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13552

FusionGeneSummary for FLII_SPATA20

check button Fusion gene summary
Fusion gene informationFusion gene name: FLII_SPATA20
Fusion gene ID: 13552
HgeneTgene
Gene symbol

FLII

SPATA20

Gene ID

2314

64847

Gene nameFLII, actin remodeling proteinspermatogenesis associated 20
SynonymsFLI|FLIL|Fli1HEL-S-98|SSP411|Tisp78
Cytomap

17p11.2

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionprotein flightless-1 homologflightless I actin binding proteinflightless I homologspermatogenesis-associated protein 20epididymis secretory protein Li 98sperm protein SSP411sperm-specific protein 411transcript increased in spermiogenesis 78
Modification date2018051920180519
UniProtAcc

Q13045

Q8TB22

Ensembl transtripts involved in fusion geneENST00000578558, ENST00000327031, 
ENST00000545457, ENST00000379450, 
ENST00000579294, ENST00000584444, 
ENST00000006658, ENST00000356488, 
ENST00000393244, ENST00000511937, 
Fusion gene scores* DoF score2 X 2 X 1=44 X 5 X 3=60
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FLII [Title/Abstract] AND SPATA20 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE075823FLIIchr17

18148734

+SPATA20chr17

48632663

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000578558ENST00000006658FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000578558ENST00000356488FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000578558ENST00000393244FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3UTRENST00000578558ENST00000511937FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000327031ENST00000006658FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000327031ENST00000356488FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000327031ENST00000393244FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3UTRENST00000327031ENST00000511937FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000545457ENST00000006658FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000545457ENST00000356488FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000545457ENST00000393244FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3UTRENST00000545457ENST00000511937FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000379450ENST00000006658FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000379450ENST00000356488FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000379450ENST00000393244FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3UTRENST00000379450ENST00000511937FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000579294ENST00000006658FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000579294ENST00000356488FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000579294ENST00000393244FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3UTRENST00000579294ENST00000511937FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000584444ENST00000006658FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000584444ENST00000356488FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3CDSENST00000584444ENST00000393244FLIIchr17

18148734

+SPATA20chr17

48632663

-
intron-3UTRENST00000584444ENST00000511937FLIIchr17

18148734

+SPATA20chr17

48632663

-

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FusionProtFeatures for FLII_SPATA20


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLII

Q13045

SPATA20

Q8TB22

May play a role as coactivator in transcriptionalactivation by hormone-activated nuclear receptors (NR) and acts incooperation with NCOA2 and CARM1. Involved in estrogen hormonesignaling. Involved in early embryonic development (Bysimilarity). May play a role in regulation of cytoskeletalrearrangements involved in cytokinesis and cell migration, byinhibiting Rac1-dependent paxillin phosphorylation. {ECO:0000250,ECO:0000269|PubMed:14966289}. May play a role in fertility regulation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FLII_SPATA20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FLII_SPATA20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FLII_SPATA20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FLII_SPATA20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource