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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 13549

FusionGeneSummary for FLI1_EWSR1

check button Fusion gene summary
Fusion gene informationFusion gene name: FLI1_EWSR1
Fusion gene ID: 13549
HgeneTgene
Gene symbol

FLI1

EWSR1

Gene ID

2313

2130

Gene nameFli-1 proto-oncogene, ETS transcription factorEWS RNA binding protein 1
SynonymsBDPLT21|EWSR2|SIC-1EWS|EWS-FLI1|bK984G1.4
Cytomap

11q24.3

22q12.2

Type of geneprotein-codingprotein-coding
DescriptionFriend leukemia integration 1 transcription factorEwing sarcoma breakpoint region 2Friend leukemia virus integration 1transcription factor ERGBRNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene
Modification date2018052720180527
UniProtAcc

Q01543

Q01844

Ensembl transtripts involved in fusion geneENST00000525560, ENST00000344954, 
ENST00000527786, ENST00000534087, 
ENST00000281428, 
ENST00000332050, 
ENST00000397938, ENST00000406548, 
ENST00000331029, ENST00000414183, 
ENST00000333395, ENST00000332035, 
Fusion gene scores* DoF score2 X 12 X 1=248 X 20 X 7=1120
# samples 1221
** MAII scorelog2(12/24*10)=2.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(21/1120*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FLI1 [Title/Abstract] AND EWSR1 [Title/Abstract] AND fusion [Title/Abstract]

Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells. (pmid: 12522555)
Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFLI1

GO:0045893

positive regulation of transcription, DNA-templated

26316623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1JX266518FLI1chr11

128667504

+EWSR1chr22

29684300

+
ChiTaRS3.1JX266523FLI1chr11

128660607

+EWSR1chr22

29684449

+
ChiTaRS3.1JX266510FLI1chr11

128667041

+EWSR1chr22

29684818

+
ChiTaRS3.1JX266528FLI1chr11

128652200

+EWSR1chr22

29685275

+
ChiTaRS3.1JX266512FLI1chr11

128650068

+EWSR1chr22

29683677

+
ChiTaRS3.1JX266514FLI1chr11

128678882

+EWSR1chr22

29684048

+
ChiTaRS3.1JX266516FLI1chr11

128675063

+EWSR1chr22

29683875

+
ChiTaRS3.1AJ229260FLI1chr11

128659606

+EWSR1chr22

29683933

+
ChiTaRS3.1AJ229265FLI1chr11

128653521

+EWSR1chr22

29683664

+
ChiTaRS3.1AJ229263FLI1chr11

128647310

+EWSR1chr22

29684764

+
ChiTaRS3.1AJ229256FLI1chr11

128646994

+EWSR1chr22

29684685

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000525560ENST00000332050FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000525560ENST00000397938FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000525560ENST00000406548FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000525560ENST00000331029FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000525560ENST00000414183FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000525560ENST00000333395FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000525560ENST00000332035FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000344954ENST00000332050FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000344954ENST00000397938FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000344954ENST00000406548FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000344954ENST00000331029FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000344954ENST00000414183FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000344954ENST00000333395FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000344954ENST00000332035FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000527786ENST00000332050FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000527786ENST00000397938FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000527786ENST00000406548FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000527786ENST00000331029FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000527786ENST00000414183FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000527786ENST00000333395FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000527786ENST00000332035FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000534087ENST00000332050FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000534087ENST00000397938FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000534087ENST00000406548FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000534087ENST00000331029FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000534087ENST00000414183FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000534087ENST00000333395FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000534087ENST00000332035FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000281428ENST00000332050FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000281428ENST00000397938FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000281428ENST00000406548FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000281428ENST00000331029FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000281428ENST00000414183FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000281428ENST00000333395FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000281428ENST00000332035FLI1chr11

128667504

+EWSR1chr22

29684300

+
intron-intronENST00000525560ENST00000332050FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000525560ENST00000397938FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000525560ENST00000406548FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000525560ENST00000331029FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000525560ENST00000414183FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000525560ENST00000333395FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000525560ENST00000332035FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000344954ENST00000332050FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000344954ENST00000397938FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000344954ENST00000406548FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000344954ENST00000331029FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000344954ENST00000414183FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000344954ENST00000333395FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000344954ENST00000332035FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000527786ENST00000332050FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000527786ENST00000397938FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000527786ENST00000406548FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000527786ENST00000331029FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000527786ENST00000414183FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000527786ENST00000333395FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000527786ENST00000332035FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000534087ENST00000332050FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000534087ENST00000397938FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000534087ENST00000406548FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000534087ENST00000331029FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000534087ENST00000414183FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000534087ENST00000333395FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000534087ENST00000332035FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000281428ENST00000332050FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000281428ENST00000397938FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000281428ENST00000406548FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000281428ENST00000331029FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000281428ENST00000414183FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000281428ENST00000333395FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000281428ENST00000332035FLI1chr11

128660607

+EWSR1chr22

29684449

+
intron-intronENST00000525560ENST00000332050FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000525560ENST00000397938FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000525560ENST00000406548FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000525560ENST00000331029FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000525560ENST00000414183FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000525560ENST00000333395FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000525560ENST00000332035FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000344954ENST00000332050FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000344954ENST00000397938FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000344954ENST00000406548FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000344954ENST00000331029FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000344954ENST00000414183FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000344954ENST00000333395FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000344954ENST00000332035FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000527786ENST00000332050FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000527786ENST00000397938FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000527786ENST00000406548FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000527786ENST00000331029FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000527786ENST00000414183FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000527786ENST00000333395FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000527786ENST00000332035FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000534087ENST00000332050FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000534087ENST00000397938FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000534087ENST00000406548FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000534087ENST00000331029FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000534087ENST00000414183FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000534087ENST00000333395FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000534087ENST00000332035FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000281428ENST00000332050FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000281428ENST00000397938FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000281428ENST00000406548FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000281428ENST00000331029FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000281428ENST00000414183FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000281428ENST00000333395FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000281428ENST00000332035FLI1chr11

128667041

+EWSR1chr22

29684818

+
intron-intronENST00000525560ENST00000332050FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000525560ENST00000397938FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000525560ENST00000406548FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000525560ENST00000331029FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000525560ENST00000414183FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000525560ENST00000333395FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000525560ENST00000332035FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000344954ENST00000332050FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000344954ENST00000397938FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000344954ENST00000406548FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000344954ENST00000331029FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000344954ENST00000414183FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000344954ENST00000333395FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000344954ENST00000332035FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000527786ENST00000332050FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000527786ENST00000397938FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000527786ENST00000406548FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000527786ENST00000331029FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000527786ENST00000414183FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000527786ENST00000333395FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000527786ENST00000332035FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000534087ENST00000332050FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000534087ENST00000397938FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000534087ENST00000406548FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000534087ENST00000331029FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000534087ENST00000414183FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000534087ENST00000333395FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000534087ENST00000332035FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000281428ENST00000332050FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000281428ENST00000397938FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000281428ENST00000406548FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000281428ENST00000331029FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000281428ENST00000414183FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000281428ENST00000333395FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000281428ENST00000332035FLI1chr11

128652200

+EWSR1chr22

29685275

+
intron-intronENST00000525560ENST00000332050FLI1chr11

128650068

+EWSR1chr22

29683677

+
intron-intronENST00000525560ENST00000397938FLI1chr11

128650068

+EWSR1chr22

29683677

+
intron-intronENST00000525560ENST00000406548FLI1chr11

128650068

+EWSR1chr22

29683677

+
intron-intronENST00000525560ENST00000331029FLI1chr11

128650068

+EWSR1chr22

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+EWSR1chr22

29684764

+
intron-intronENST00000525560ENST00000332035FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000344954ENST00000332050FLI1chr11

128647310

+EWSR1chr22

29684764

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intron-intronENST00000344954ENST00000397938FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000344954ENST00000406548FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000344954ENST00000331029FLI1chr11

128647310

+EWSR1chr22

29684764

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intron-intronENST00000344954ENST00000414183FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000344954ENST00000333395FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000344954ENST00000332035FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000527786ENST00000332050FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000527786ENST00000397938FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000527786ENST00000406548FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000527786ENST00000331029FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000527786ENST00000414183FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000527786ENST00000333395FLI1chr11

128647310

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29684764

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intron-intronENST00000527786ENST00000332035FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000534087ENST00000332050FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000534087ENST00000397938FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000534087ENST00000406548FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000534087ENST00000331029FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000534087ENST00000414183FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000534087ENST00000333395FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000534087ENST00000332035FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000281428ENST00000332050FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000281428ENST00000397938FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000281428ENST00000406548FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000281428ENST00000331029FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000281428ENST00000414183FLI1chr11

128647310

+EWSR1chr22

29684764

+
intron-intronENST00000281428ENST00000333395FLI1chr11

128647310

+EWSR1chr22

29684764

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intron-intronENST00000281428ENST00000332035FLI1chr11

128647310

+EWSR1chr22

29684764

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intron-intronENST00000525560ENST00000332050FLI1chr11

128646994

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29684685

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intron-intronENST00000525560ENST00000397938FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000525560ENST00000406548FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000525560ENST00000331029FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000525560ENST00000414183FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000525560ENST00000333395FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000525560ENST00000332035FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000344954ENST00000332050FLI1chr11

128646994

+EWSR1chr22

29684685

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intron-intronENST00000344954ENST00000397938FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000344954ENST00000406548FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000344954ENST00000331029FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000344954ENST00000414183FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000344954ENST00000333395FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000344954ENST00000332035FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000527786ENST00000332050FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000527786ENST00000397938FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000527786ENST00000406548FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000527786ENST00000331029FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000527786ENST00000414183FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000527786ENST00000333395FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000527786ENST00000332035FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000534087ENST00000332050FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000534087ENST00000397938FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000534087ENST00000406548FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000534087ENST00000331029FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000534087ENST00000414183FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000534087ENST00000333395FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000534087ENST00000332035FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000281428ENST00000332050FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000281428ENST00000397938FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000281428ENST00000406548FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000281428ENST00000331029FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000281428ENST00000414183FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000281428ENST00000333395FLI1chr11

128646994

+EWSR1chr22

29684685

+
intron-intronENST00000281428ENST00000332035FLI1chr11

128646994

+EWSR1chr22

29684685

+

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FusionProtFeatures for FLI1_EWSR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLI1

Q01543

EWSR1

Q01844

Sequence-specific transcriptional activator(PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizesthe DNA sequence 5'-C[CA]GGAAGT-3'. {ECO:0000269|PubMed:24100448,ECO:0000269|PubMed:26316623, ECO:0000269|PubMed:28255014}. Might normally function as a transcriptional repressor.EWS-fusion-proteins (EFPS) may play a role in the tumorigenicprocess. They may disturb gene expression by mimicking, orinterfering with the normal function of CTD-POLII within thetranscription initiation complex. They may also contribute to anaberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FLI1_EWSR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FLI1_EWSR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FLI1_EWSR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FLI1_EWSR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFLI1C0553580Ewings sarcoma3CTD_human;ORPHANET
HgeneFLI1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneFLI1C0025149Medulloblastoma1CTD_human
TgeneEWSR1C0553580Ewings sarcoma3CTD_human;HPO;ORPHANET
TgeneEWSR1C0206663Neuroectodermal Tumor, Primitive1CTD_human