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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13547

FusionGeneSummary for FLAD1_UBAP2L

check button Fusion gene summary
Fusion gene informationFusion gene name: FLAD1_UBAP2L
Fusion gene ID: 13547
HgeneTgene
Gene symbol

FLAD1

UBAP2L

Gene ID

80308

9898

Gene nameflavin adenine dinucleotide synthetase 1ubiquitin associated protein 2 like
SynonymsFAD1|FADS|LSMFLAD|PP591NICE-4|NICE4
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
DescriptionFAD synthaseFAD pyrophosphorylaseFAD-synthetaseFMN adenylyltransferaseFad1, flavin adenine dinucleotide synthetase, homologubiquitin-associated protein 2-likeprotein NICE-4
Modification date2018052320180523
UniProtAcc

Q8NFF5

Q14157

Ensembl transtripts involved in fusion geneENST00000368433, ENST00000315144, 
ENST00000368432, ENST00000368431, 
ENST00000292180, ENST00000487371, 
ENST00000405236, ENST00000295530, 
ENST00000368428, 
ENST00000343815, 
ENST00000428931, ENST00000271877, 
ENST00000361546, ENST00000484819, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 3=75
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FLAD1 [Title/Abstract] AND UBAP2L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0BZ-01AFLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000368433ENST00000343815FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368433ENST00000428931FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368433ENST00000271877FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368433ENST00000361546FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-intronENST00000368433ENST00000484819FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000315144ENST00000343815FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000315144ENST00000428931FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000315144ENST00000271877FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000315144ENST00000361546FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-intronENST00000315144ENST00000484819FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368432ENST00000343815FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368432ENST00000428931FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368432ENST00000271877FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368432ENST00000361546FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-intronENST00000368432ENST00000484819FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368431ENST00000343815FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368431ENST00000428931FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368431ENST00000271877FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000368431ENST00000361546FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-intronENST00000368431ENST00000484819FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000292180ENST00000343815FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000292180ENST00000428931FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000292180ENST00000271877FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-3CDSENST00000292180ENST00000361546FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
5UTR-intronENST00000292180ENST00000484819FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000487371ENST00000343815FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000487371ENST00000428931FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000487371ENST00000271877FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000487371ENST00000361546FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-intronENST00000487371ENST00000484819FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000405236ENST00000343815FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000405236ENST00000428931FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000405236ENST00000271877FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000405236ENST00000361546FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-intronENST00000405236ENST00000484819FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000295530ENST00000343815FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000295530ENST00000428931FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000295530ENST00000271877FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000295530ENST00000361546FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-intronENST00000295530ENST00000484819FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000368428ENST00000343815FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000368428ENST00000428931FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000368428ENST00000271877FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-3CDSENST00000368428ENST00000361546FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+
intron-intronENST00000368428ENST00000484819FLAD1chr1

154955873

+UBAP2Lchr1

154199758

+

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FusionProtFeatures for FLAD1_UBAP2L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FLAD1

Q8NFF5

UBAP2L

Q14157

Catalyzes the adenylation of flavin mononucleotide (FMN)to form flavin adenine dinucleotide (FAD) coenzyme.{ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:27259049}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FLAD1_UBAP2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FLAD1_UBAP2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FLAD1TRIM23, PRTFDC1, FLAD1, ICT1, NUDT21, GRB7, TK1, CDKN1A, SMN1, RCC1, ANXA7, DAK, SORD, GEMIN4, TNRC6B, REL, SDCBP, TCF4, MOV10, NXF1, KLHL14, PSG1, PLEKHO2, PSPH, SH3GLB1, PFAS, FAM19A3, FSCN3, PTPN1UBAP2LPRRC2A, MLH1, PMS1, NEDD4, ITCH, PLXNA2, ELAVL1, SIRT7, ISG15, ZP3, CUL3, COPS5, ATXN1, YEATS2, CPSF6, YBX1, SF3B1, CPSF7, UBAP2, MED15, XRCC1, UBE2H, VAPA, VAMP2, ACAT1, ESR1, FN1, VCAM1, METTL20, ITGA4, BAG3, NLK, FUS, NXF1, OBSL1, BMI1, ILK, FBXW11, HNRNPDL, ANLN, CDV3, NTRK1, PTEN, KAT2A, MED4, XPO1, PRMT1, RC3H1, UBR5, EGFR, MTNR1A, MTNR1B, DLD, TRIM25, G3BP1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FLAD1_UBAP2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FLAD1_UBAP2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFLAD1C0410214Myopathy with Abnormal Lipid Metabolism1UNIPROT