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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13540

FusionGeneSummary for FKBP8_PRSS23

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP8_PRSS23
Fusion gene ID: 13540
HgeneTgene
Gene symbol

FKBP8

PRSS23

Gene ID

23770

11098

Gene nameFK506 binding protein 8serine protease 23
SynonymsFKBP38|FKBPr38SIG13|SPUVE|ZSIG13
Cytomap

19p13.11

11q14.2

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase FKBP838 kDa FK506-binding protein38 kDa FKBPFK506 binding protein 8, 38kDaFKBP-38FKBP-8PPIase FKBP8hFKBP38rotamaseserine protease 23protease, serine 23putative secreted protein Zsig13serine protease, umbilical endothelium
Modification date2018052220180524
UniProtAcc

Q14318

O95084

Ensembl transtripts involved in fusion geneENST00000597960, ENST00000610101, 
ENST00000596558, ENST00000222308, 
ENST00000608443, ENST00000453489, 
ENST00000533902, ENST00000280258, 
ENST00000441050, ENST00000531521, 
Fusion gene scores* DoF score10 X 11 X 4=4408 X 9 X 3=216
# samples 1111
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/216*10)=-0.973527788638809
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FKBP8 [Title/Abstract] AND PRSS23 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ421142FKBP8chr19

18652550

-PRSS23chr11

86518710

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000597960ENST00000533902FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000597960ENST00000280258FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000597960ENST00000441050FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000597960ENST00000531521FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000610101ENST00000533902FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000610101ENST00000280258FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000610101ENST00000441050FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000610101ENST00000531521FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000596558ENST00000533902FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000596558ENST00000280258FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000596558ENST00000441050FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000596558ENST00000531521FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000222308ENST00000533902FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000222308ENST00000280258FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000222308ENST00000441050FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000222308ENST00000531521FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000608443ENST00000533902FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000608443ENST00000280258FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000608443ENST00000441050FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000608443ENST00000531521FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000453489ENST00000533902FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000453489ENST00000280258FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000453489ENST00000441050FKBP8chr19

18652550

-PRSS23chr11

86518710

+
intron-intronENST00000453489ENST00000531521FKBP8chr19

18652550

-PRSS23chr11

86518710

+

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FusionProtFeatures for FKBP8_PRSS23


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP8

Q14318

PRSS23

O95084

Constitutively inactive PPiase, which becomes activewhen bound to calmodulin and calcium. Seems to act as a chaperonefor BCL2, targets it to the mitochondria and modulates itsphosphorylation state. The BCL2/FKBP8/calmodulin/calcium complexprobably interferes with the binding of BCL2 to its targets. Theactive form of FKBP8 may therefore play a role in the regulationof apoptosis. {ECO:0000269|PubMed:12510191,ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FKBP8_PRSS23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FKBP8_PRSS23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FKBP8_PRSS23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FKBP8_PRSS23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRSS23C0025202melanoma1CTD_human