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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13536

FusionGeneSummary for FKBP8_LIG4

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP8_LIG4
Fusion gene ID: 13536
HgeneTgene
Gene symbol

FKBP8

LIG4

Gene ID

23770

3981

Gene nameFK506 binding protein 8DNA ligase 4
SynonymsFKBP38|FKBPr38LIG4S
Cytomap

19p13.11

13q33.3

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase FKBP838 kDa FK506-binding protein38 kDa FKBPFK506 binding protein 8, 38kDaFKBP-38FKBP-8PPIase FKBP8hFKBP38rotamaseDNA ligase 4DNA joinaseDNA ligase IVDNA repair enzymeligase IV, DNA, ATP-dependentpolydeoxyribonucleotide synthase [ATP] 4polynucleotide ligasesealase
Modification date2018052220180523
UniProtAcc

Q14318

P49917

Ensembl transtripts involved in fusion geneENST00000597960, ENST00000610101, 
ENST00000596558, ENST00000222308, 
ENST00000608443, ENST00000453489, 
ENST00000356922, ENST00000442234, 
ENST00000405925, 
Fusion gene scores* DoF score10 X 11 X 4=4401 X 1 X 1=1
# samples 111
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: FKBP8 [Title/Abstract] AND LIG4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneLIG4

GO:0000012

single strand break repair

8798671

TgeneLIG4

GO:0006266

DNA ligation

12517771

TgeneLIG4

GO:0006297

nucleotide-excision repair, DNA gap filling

12517771

TgeneLIG4

GO:0006302

double-strand break repair

9242410|19589734

TgeneLIG4

GO:0006303

double-strand break repair via nonhomologous end joining

12517771

TgeneLIG4

GO:0033151

V(D)J recombination

9809069

TgeneLIG4

GO:0051103

DNA ligation involved in DNA repair

12517771


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA732934FKBP8chr19

18642910

+LIG4chr13

108867019

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000597960ENST00000356922FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000597960ENST00000442234FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000597960ENST00000405925FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-5UTRENST00000610101ENST00000356922FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000610101ENST00000442234FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000610101ENST00000405925FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-5UTRENST00000596558ENST00000356922FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000596558ENST00000442234FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000596558ENST00000405925FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-5UTRENST00000222308ENST00000356922FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000222308ENST00000442234FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000222308ENST00000405925FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-5UTRENST00000608443ENST00000356922FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000608443ENST00000442234FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000608443ENST00000405925FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-5UTRENST00000453489ENST00000356922FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000453489ENST00000442234FKBP8chr19

18642910

+LIG4chr13

108867019

+
intron-intronENST00000453489ENST00000405925FKBP8chr19

18642910

+LIG4chr13

108867019

+

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FusionProtFeatures for FKBP8_LIG4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP8

Q14318

LIG4

P49917

Constitutively inactive PPiase, which becomes activewhen bound to calmodulin and calcium. Seems to act as a chaperonefor BCL2, targets it to the mitochondria and modulates itsphosphorylation state. The BCL2/FKBP8/calmodulin/calcium complexprobably interferes with the binding of BCL2 to its targets. Theactive form of FKBP8 may therefore play a role in the regulationof apoptosis. {ECO:0000269|PubMed:12510191,ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}. Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction.Involved in DNA non-homologous end joining (NHEJ) required fordouble-strand break repair and V(D)J recombination. The LIG4-XRCC4complex is responsible for the NHEJ ligation step, and XRCC4enhances the joining activity of LIG4. Binding of the LIG4-XRCC4complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.{ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:9809069}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FKBP8_LIG4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FKBP8_LIG4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FKBP8_LIG4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FKBP8_LIG4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLIG4C1847827LIG4 Syndrome1CTD_human;ORPHANET;UNIPROT