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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13511

FusionGeneSummary for FKBP3_NUB1

check button Fusion gene summary
Fusion gene informationFusion gene name: FKBP3_NUB1
Fusion gene ID: 13511
HgeneTgene
Gene symbol

FKBP3

NUB1

Gene ID

2287

51667

Gene nameFK506 binding protein 3negative regulator of ubiquitin like proteins 1
SynonymsFKBP-25|FKBP-3|FKBP25|PPIaseBS4|NUB1L|NYREN18
Cytomap

14q21.2

7q36.1

Type of geneprotein-codingprotein-coding
Descriptionpeptidyl-prolyl cis-trans isomerase FKBP325 kDa FK506-binding protein25 kDa FKBPFK506 binding protein 3, 25kDaFK506-binding protein 25, T-cellPPIase FKBP3immunophilin FKBP25rapamycin binding proteinrapamycin-selective 25 kDa immunophilinrotamaseNEDD8 ultimate buster 1NEDD8 ultimate buster-1renal carcinoma antigen NY-REN-18
Modification date2018052220180525
UniProtAcc

Q00688

Q9Y5A7

Ensembl transtripts involved in fusion geneENST00000396062, ENST00000216330, 
ENST00000413040, ENST00000568733, 
ENST00000566856, ENST00000355851, 
ENST00000477666, 
Fusion gene scores* DoF score6 X 5 X 3=905 X 5 X 3=75
# samples 65
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FKBP3 [Title/Abstract] AND NUB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A15A-01AFKBP3chr14

45598997

-NUB1chr7

151064025

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000396062ENST00000413040FKBP3chr14

45598997

-NUB1chr7

151064025

+
Frame-shiftENST00000396062ENST00000568733FKBP3chr14

45598997

-NUB1chr7

151064025

+
Frame-shiftENST00000396062ENST00000566856FKBP3chr14

45598997

-NUB1chr7

151064025

+
Frame-shiftENST00000396062ENST00000355851FKBP3chr14

45598997

-NUB1chr7

151064025

+
5CDS-intronENST00000396062ENST00000477666FKBP3chr14

45598997

-NUB1chr7

151064025

+
Frame-shiftENST00000216330ENST00000413040FKBP3chr14

45598997

-NUB1chr7

151064025

+
Frame-shiftENST00000216330ENST00000568733FKBP3chr14

45598997

-NUB1chr7

151064025

+
Frame-shiftENST00000216330ENST00000566856FKBP3chr14

45598997

-NUB1chr7

151064025

+
Frame-shiftENST00000216330ENST00000355851FKBP3chr14

45598997

-NUB1chr7

151064025

+
5CDS-intronENST00000216330ENST00000477666FKBP3chr14

45598997

-NUB1chr7

151064025

+

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FusionProtFeatures for FKBP3_NUB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FKBP3

Q00688

NUB1

Q9Y5A7

FK506- and rapamycin-binding proteins (FKBPs) constitutea family of receptors for the two immunosuppressants which inhibitT-cell proliferation by arresting two distinct cytoplasmic signaltransmission pathways. PPIases accelerate the folding of proteins. Specific down-regulator of the NEDD8 conjugation system.Recruits NEDD8, UBD, and their conjugates to the proteasome fordegradation. Isoform 1 promotes the degradation of NEDD8 moreefficiently than isoform 2. {ECO:0000269|PubMed:16707496}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FKBP3_NUB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FKBP3_NUB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FKBP3MTA2, HDAC1, HDAC2, YY1, MDM2, TP53, CALM1, NEDD4L, NEDD4, PACSIN3, TIMELESS, LRRFIP1, MYH10, BARD1, FBXO25, SRPK1, ABCF1, C14orf166, NELFB, DDX1, DIMT1, DYNLL1, EDC4, EIF2B2, EIF2B3, HNRNPA2B1, HNRNPU, IGF2BP3, ILF2, KRT18, MAP1S, NMT1, RFC4, SEC16A, SYNCRIP, YBX1, CGGBP1, NTRK1, EWSR1, CEP19, SMURF1NUB1FANCA, UBD, NEDD8, PSMD4, AIPL1, TP53, PSMD2, FAT1, PSMB4, SNCAIP, UBE2K, HSPA4, MAPT, GSK3B, ECT2, COPB1, VCP, UFD1L, SHFM1, SF3B4, UBC, RNF168, TERF1, VAV1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FKBP3_NUB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FKBP3_NUB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource