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Fusion gene ID: 13476 |
FusionGeneSummary for FIGN_STK25 |
Fusion gene summary |
Fusion gene information | Fusion gene name: FIGN_STK25 | Fusion gene ID: 13476 | Hgene | Tgene | Gene symbol | FIGN | STK25 | Gene ID | 55137 | 10494 |
Gene name | fidgetin, microtubule severing factor | serine/threonine kinase 25 | |
Synonyms | - | SOK1|YSK1 | |
Cytomap | 2q24.3 | 2q37.3 | |
Type of gene | protein-coding | protein-coding | |
Description | fidgetin | serine/threonine-protein kinase 25Ste20, yeast homologste20-like kinaseste20/oxidant stress response kinase 1sterile 20/oxidant stress-response kinase 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q5HY92 | O00506 | |
Ensembl transtripts involved in fusion gene | ENST00000409634, ENST00000333129, ENST00000482917, | ENST00000316586, ENST00000403346, ENST00000401869, ENST00000405883, ENST00000405585, ENST00000543554, ENST00000478403, ENST00000535007, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: FIGN [Title/Abstract] AND STK25 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | STK25 | GO:0006468 | protein phosphorylation | 17657516 |
Tgene | STK25 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 22652780 |
Tgene | STK25 | GO:0042542 | response to hydrogen peroxide | 22291017 |
Tgene | STK25 | GO:0046777 | protein autophosphorylation | 17657516 |
Tgene | STK25 | GO:0051645 | Golgi localization | 15037601 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-KP-A3VZ-01A | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000409634 | ENST00000316586 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
Frame-shift | ENST00000409634 | ENST00000403346 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
Frame-shift | ENST00000409634 | ENST00000401869 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
5CDS-intron | ENST00000409634 | ENST00000405883 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
5CDS-intron | ENST00000409634 | ENST00000405585 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
5CDS-5UTR | ENST00000409634 | ENST00000543554 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
5CDS-intron | ENST00000409634 | ENST00000478403 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
5CDS-5UTR | ENST00000409634 | ENST00000535007 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
Frame-shift | ENST00000333129 | ENST00000316586 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
Frame-shift | ENST00000333129 | ENST00000403346 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
Frame-shift | ENST00000333129 | ENST00000401869 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
5CDS-intron | ENST00000333129 | ENST00000405883 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
5CDS-intron | ENST00000333129 | ENST00000405585 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
5CDS-5UTR | ENST00000333129 | ENST00000543554 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
5CDS-intron | ENST00000333129 | ENST00000478403 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
5CDS-5UTR | ENST00000333129 | ENST00000535007 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
intron-3CDS | ENST00000482917 | ENST00000316586 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
intron-3CDS | ENST00000482917 | ENST00000403346 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
intron-3CDS | ENST00000482917 | ENST00000401869 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
intron-intron | ENST00000482917 | ENST00000405883 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
intron-intron | ENST00000482917 | ENST00000405585 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
intron-5UTR | ENST00000482917 | ENST00000543554 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
intron-intron | ENST00000482917 | ENST00000478403 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
intron-5UTR | ENST00000482917 | ENST00000535007 | FIGN | chr2 | 164591413 | - | STK25 | chr2 | 242441123 | - |
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FusionProtFeatures for FIGN_STK25 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
FIGN | STK25 |
ATP-dependent microtubule severing protein. Seversmicrotubules along their length and depolymerizes their ends,primarily the minus-end, that may lead to the suppression ofmicrotubule growth from and attachment to centrosomes. Microtubulesevering may promote rapid reorganization of cellular microtubulearrays and the release of microtubules from the centrosomefollowing nucleation. Microtubule release from the mitotic spindlepoles may allow depolymerization of the microtubule end proximalto the spindle pole, leading to poleward microtubule flux andpoleward motion of chromosome. {ECO:0000269|PubMed:22672901}. | Oxidant stress-activated serine/threonine kinase thatmay play a role in the response to environmental stress. Targetsto the Golgi apparatus where it appears to regulate proteintransport events, cell adhesion, and polarity complexes importantfor cell migration. {ECO:0000269|PubMed:15037601}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FIGN_STK25 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FIGN_STK25 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FIGN | COPS5, LANCL1, ERP44 | STK25 | PDCD10, STK24, MOB4, PPP2R1A, PPP2CA, STRN, STRIP1, STRN3, PPP2R1B, STRN4, CTTNBP2NL, SIKE1, STRIP2, SLMAP, TCP1, FGFR1OP2, USP36, IKBKG, UBE2D3, NEDD4, LRRK2, APP, MAPK9, PPP2CB, DYNLL1, GOLGA2, ACACA, TAOK1, CTTNBP2, STK26, TRIM27, CCNDBP1, CEP70, CCDC36, ZDHHC17, C4orf19, MOS, ACAD11, MTPAP, TAOK2, ARV1, HBS1L, GORASP1, KIF20A, CAB39, MTMR6, ZNF598, ARL13B, EIF4A3, RPL12, PROSER2, PBX2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FIGN_STK25 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FIGN_STK25 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |