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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13466

FusionGeneSummary for FHOD3_MS4A15

check button Fusion gene summary
Fusion gene informationFusion gene name: FHOD3_MS4A15
Fusion gene ID: 13466
HgeneTgene
Gene symbol

FHOD3

MS4A15

Gene ID

91010

219995

Gene nameformin like 3membrane spanning 4-domains A15
SynonymsFHOD3|FRL2|WBP-3|WBP3-
Cytomap

12q13.12

11q12.2

Type of geneprotein-codingprotein-coding
Descriptionformin-like protein 3WW domain binding protein 3formin homology 2 domain-containing protein 3membrane-spanning 4-domains subfamily A member 15
Modification date2018051920180329
UniProtAcc

Q2V2M9

Q8N5U1

Ensembl transtripts involved in fusion geneENST00000257209, ENST00000445677, 
ENST00000590592, ENST00000359247, 
ENST00000591635, ENST00000592128, 
ENST00000587493, 
ENST00000528170, 
ENST00000337911, ENST00000405633, 
Fusion gene scores* DoF score8 X 5 X 7=2802 X 2 X 2=8
# samples 112
** MAII scorelog2(11/280*10)=-1.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: FHOD3 [Title/Abstract] AND MS4A15 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CV-5440-01AFHOD3chr18

34267141

+MS4A15chr11

60531179

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000257209ENST00000528170FHOD3chr18

34267141

+MS4A15chr11

60531179

+
5CDS-intronENST00000257209ENST00000337911FHOD3chr18

34267141

+MS4A15chr11

60531179

+
5CDS-5UTRENST00000257209ENST00000405633FHOD3chr18

34267141

+MS4A15chr11

60531179

+
5CDS-5UTRENST00000445677ENST00000528170FHOD3chr18

34267141

+MS4A15chr11

60531179

+
5CDS-intronENST00000445677ENST00000337911FHOD3chr18

34267141

+MS4A15chr11

60531179

+
5CDS-5UTRENST00000445677ENST00000405633FHOD3chr18

34267141

+MS4A15chr11

60531179

+
5CDS-5UTRENST00000590592ENST00000528170FHOD3chr18

34267141

+MS4A15chr11

60531179

+
5CDS-intronENST00000590592ENST00000337911FHOD3chr18

34267141

+MS4A15chr11

60531179

+
5CDS-5UTRENST00000590592ENST00000405633FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-5UTRENST00000359247ENST00000528170FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-intronENST00000359247ENST00000337911FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-5UTRENST00000359247ENST00000405633FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-5UTRENST00000591635ENST00000528170FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-intronENST00000591635ENST00000337911FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-5UTRENST00000591635ENST00000405633FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-5UTRENST00000592128ENST00000528170FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-intronENST00000592128ENST00000337911FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-5UTRENST00000592128ENST00000405633FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-5UTRENST00000587493ENST00000528170FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-intronENST00000587493ENST00000337911FHOD3chr18

34267141

+MS4A15chr11

60531179

+
intron-5UTRENST00000587493ENST00000405633FHOD3chr18

34267141

+MS4A15chr11

60531179

+

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FusionProtFeatures for FHOD3_MS4A15


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FHOD3

Q2V2M9

MS4A15

Q8N5U1

May be involved in signal transduction as a component ofa multimeric receptor complex. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FHOD3_MS4A15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FHOD3_MS4A15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FHOD3SQSTM1, HERC2MS4A15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FHOD3_MS4A15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FHOD3_MS4A15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFHOD3C0236969Substance-Related Disorders1CTD_human