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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13425

FusionGeneSummary for FGGY_CASC11

check button Fusion gene summary
Fusion gene informationFusion gene name: FGGY_CASC11
Fusion gene ID: 13425
HgeneTgene
Gene symbol

FGGY

CASC11

Gene ID

55277

100270680

Gene nameFGGY carbohydrate kinase domain containingcancer susceptibility 11
Synonyms-CARLO7|CARLo-7|LINC00990|TCONS_00014535
Cytomap

1p32.1

8q24.21

Type of geneprotein-codingncRNA
DescriptionFGGY carbohydrate kinase domain-containing proteinD-ribulokinasecancer susceptibility 11 (non-protein coding)cancer susceptibility candidate 11 (non-protein coding)long intergenic non-protein coding RNA 990
Modification date2018051920180517
UniProtAcc

Q96C11

Ensembl transtripts involved in fusion geneENST00000474476, ENST00000371218, 
ENST00000303721, ENST00000371212, 
ENST00000371210, 
ENST00000502463, 
Fusion gene scores* DoF score7 X 5 X 4=1404 X 3 X 4=48
# samples 75
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FGGY [Title/Abstract] AND CASC11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGGY

GO:0019321

pentose metabolic process

27909055

HgeneFGGY

GO:0046835

carbohydrate phosphorylation

27909055


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-85-8351-01AFGGYchr1

59922748

+CASC11chr8

128701668

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000474476ENST00000502463FGGYchr1

59922748

+CASC11chr8

128701668

-
5CDS-5UTRENST00000371218ENST00000502463FGGYchr1

59922748

+CASC11chr8

128701668

-
5CDS-5UTRENST00000303721ENST00000502463FGGYchr1

59922748

+CASC11chr8

128701668

-
5CDS-5UTRENST00000371212ENST00000502463FGGYchr1

59922748

+CASC11chr8

128701668

-
intron-5UTRENST00000371210ENST00000502463FGGYchr1

59922748

+CASC11chr8

128701668

-

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FusionProtFeatures for FGGY_CASC11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGGY

Q96C11

CASC11

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGGY_CASC11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGGY_CASC11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGGYEAF1, NSFL1CCASC11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGGY_CASC11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FGGY_CASC11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource