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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13424

FusionGeneSummary for FGGY_ATP2B4

check button Fusion gene summary
Fusion gene informationFusion gene name: FGGY_ATP2B4
Fusion gene ID: 13424
HgeneTgene
Gene symbol

FGGY

ATP2B4

Gene ID

55277

493

Gene nameFGGY carbohydrate kinase domain containingATPase plasma membrane Ca2+ transporting 4
Synonyms-ATP2B2|MXRA1|PMCA4|PMCA4b|PMCA4x
Cytomap

1p32.1

1q32.1

Type of geneprotein-codingprotein-coding
DescriptionFGGY carbohydrate kinase domain-containing proteinD-ribulokinaseplasma membrane calcium-transporting ATPase 4ATPase, Ca++ transporting, plasma membrane 4matrix-remodeling-associated protein 1sarcolemmal calcium pump
Modification date2018051920180523
UniProtAcc

Q96C11

P23634

Ensembl transtripts involved in fusion geneENST00000474476, ENST00000371218, 
ENST00000303721, ENST00000371212, 
ENST00000371210, 
ENST00000357681, 
ENST00000391954, ENST00000367218, 
ENST00000367219, ENST00000341360, 
ENST00000466407, 
Fusion gene scores* DoF score7 X 5 X 4=14010 X 9 X 6=540
# samples 710
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGGY [Title/Abstract] AND ATP2B4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGGY

GO:0019321

pentose metabolic process

27909055

HgeneFGGY

GO:0046835

carbohydrate phosphorylation

27909055

TgeneATP2B4

GO:0006874

cellular calcium ion homeostasis

19278978

TgeneATP2B4

GO:0010751

negative regulation of nitric oxide mediated signal transduction

19278978

TgeneATP2B4

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19278978

TgeneATP2B4

GO:0045019

negative regulation of nitric oxide biosynthetic process

11591728|19278978

TgeneATP2B4

GO:0051001

negative regulation of nitric-oxide synthase activity

11591728|17242280|19278978|19287093

TgeneATP2B4

GO:0070885

negative regulation of calcineurin-NFAT signaling cascade

19287093

TgeneATP2B4

GO:0071872

cellular response to epinephrine stimulus

19278978

TgeneATP2B4

GO:0098736

negative regulation of the force of heart contraction

17242280

TgeneATP2B4

GO:0140199

negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

17242280

TgeneATP2B4

GO:1900082

negative regulation of arginine catabolic process

19278978

TgeneATP2B4

GO:1903249

negative regulation of citrulline biosynthetic process

19278978

TgeneATP2B4

GO:2000481

positive regulation of cAMP-dependent protein kinase activity

19278978


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A23U-01AFGGYchr1

59922748

+ATP2B4chr1

203676990

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000474476ENST00000357681FGGYchr1

59922748

+ATP2B4chr1

203676990

+
3UTR-3CDSENST00000474476ENST00000391954FGGYchr1

59922748

+ATP2B4chr1

203676990

+
3UTR-3CDSENST00000474476ENST00000367218FGGYchr1

59922748

+ATP2B4chr1

203676990

+
3UTR-3CDSENST00000474476ENST00000367219FGGYchr1

59922748

+ATP2B4chr1

203676990

+
3UTR-3CDSENST00000474476ENST00000341360FGGYchr1

59922748

+ATP2B4chr1

203676990

+
3UTR-intronENST00000474476ENST00000466407FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000371218ENST00000357681FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000371218ENST00000391954FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000371218ENST00000367218FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000371218ENST00000367219FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000371218ENST00000341360FGGYchr1

59922748

+ATP2B4chr1

203676990

+
5CDS-intronENST00000371218ENST00000466407FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000303721ENST00000357681FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000303721ENST00000391954FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000303721ENST00000367218FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000303721ENST00000367219FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000303721ENST00000341360FGGYchr1

59922748

+ATP2B4chr1

203676990

+
5CDS-intronENST00000303721ENST00000466407FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000371212ENST00000357681FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000371212ENST00000391954FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000371212ENST00000367218FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000371212ENST00000367219FGGYchr1

59922748

+ATP2B4chr1

203676990

+
Frame-shiftENST00000371212ENST00000341360FGGYchr1

59922748

+ATP2B4chr1

203676990

+
5CDS-intronENST00000371212ENST00000466407FGGYchr1

59922748

+ATP2B4chr1

203676990

+
intron-3CDSENST00000371210ENST00000357681FGGYchr1

59922748

+ATP2B4chr1

203676990

+
intron-3CDSENST00000371210ENST00000391954FGGYchr1

59922748

+ATP2B4chr1

203676990

+
intron-3CDSENST00000371210ENST00000367218FGGYchr1

59922748

+ATP2B4chr1

203676990

+
intron-3CDSENST00000371210ENST00000367219FGGYchr1

59922748

+ATP2B4chr1

203676990

+
intron-3CDSENST00000371210ENST00000341360FGGYchr1

59922748

+ATP2B4chr1

203676990

+
intron-intronENST00000371210ENST00000466407FGGYchr1

59922748

+ATP2B4chr1

203676990

+

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FusionProtFeatures for FGGY_ATP2B4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGGY

Q96C11

ATP2B4

P23634

Calcium/calmodulin-regulated and magnesium-dependentenzyme that catalyzes the hydrolysis of ATP coupled with thetransport of calcium out of the cell (PubMed:8530416). Byregulating sperm cell calcium homeostasis, may play a role insperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477,ECO:0000269|PubMed:8530416}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGGY_ATP2B4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGGY_ATP2B4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGGYEAF1, NSFL1CATP2B4DLG1, CASK, DLG2, DLG3, ERBB2IP, ADRB2, CDK7, LGALS3, BSG, LGALS8, TAS2R7, EDA2R, HSD17B6, LGALS9, AGTR1, LGALS9C, SLC39A4, LYPD3, DLK1, WBP1, PTGER3, TMEM52B, ATP1A1, ATP9A, HM13, ATP5J, CANX, CLGN, TMEM17, EGFR, CDH1, CTDSPL, ATP2B2, TMEM5, LPAR1, LILRB4, FPR2, IPPK, FAM174A, C3AR1, GPC1, CYP2B6, PCDHGB1, APLNR, KCNA5, NMUR2, HTR3A, VAC14, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGGY_ATP2B4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FGGY_ATP2B4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource