FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13397

FusionGeneSummary for FGFR2_AP1M1

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR2_AP1M1
Fusion gene ID: 13397
HgeneTgene
Gene symbol

FGFR2

AP1M1

Gene ID

2263

8907

Gene namefibroblast growth factor receptor 2adaptor related protein complex 1 subunit mu 1
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25AP47|CLAPM2|CLTNM|MU-1A
Cytomap

10q26.13

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14AP-1 complex subunit mu-1AP-mu chain family member mu1AHA1 47 kDa subunitadapter-related protein complex 1 subunit mu-1adaptor protein complex AP-1 mu-1 subunitadaptor protein complex AP-1 subunit mu-1adaptor related protein complex 1 mu 1 subunitc
Modification date2018052720180519
UniProtAcc

P21802

Q9BXS5

Ensembl transtripts involved in fusion geneENST00000369061, ENST00000357555, 
ENST00000358487, ENST00000356226, 
ENST00000369060, ENST00000369059, 
ENST00000346997, ENST00000457416, 
ENST00000351936, ENST00000360144, 
ENST00000369056, ENST00000490349, 
ENST00000359354, ENST00000478859, 
ENST00000291439, ENST00000541844, 
ENST00000590756, ENST00000429941, 
ENST00000444449, 
Fusion gene scores* DoF score18 X 10 X 9=16203 X 3 X 2=18
# samples 243
** MAII scorelog2(24/1620*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FGFR2 [Title/Abstract] AND AP1M1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AQ-A04L-01BFGFR2chr10

123256046

-AP1M1chr19

16314270

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000369061ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369061ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369061ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369061ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369061ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000357555ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000357555ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000357555ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000357555ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000357555ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000358487ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000358487ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000358487ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000358487ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000358487ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000356226ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000356226ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000356226ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000356226ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000356226ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000369060ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369060ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369060ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369060ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369060ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000369059ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369059ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369059ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369059ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369059ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
In-frameENST00000346997ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000346997ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000346997ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000346997ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000346997ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000457416ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000457416ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000457416ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000457416ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000457416ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000351936ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000351936ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000351936ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000351936ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000351936ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000360144ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000360144ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000360144ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000360144ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000360144ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
In-frameENST00000369056ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369056ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369056ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369056ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000369056ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-3CDSENST00000490349ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000490349ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000490349ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000490349ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000490349ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-3CDSENST00000359354ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000359354ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000359354ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000359354ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
intron-intronENST00000359354ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+
Frame-shiftENST00000478859ENST00000291439FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000478859ENST00000541844FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000478859ENST00000590756FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000478859ENST00000429941FGFR2chr10

123256046

-AP1M1chr19

16314270

+
5CDS-intronENST00000478859ENST00000444449FGFR2chr10

123256046

-AP1M1chr19

16314270

+

Top

FusionProtFeatures for FGFR2_AP1M1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

AP1M1

Q9BXS5

Subunit of clathrin-associated adaptor protein complex 1that plays a role in protein sorting in the trans-Golgi network(TGN) and endosomes. The AP complexes mediate the recruitment ofclathrin to membranes and the recognition of sorting signalswithin the cytosolic tails of transmembrane cargo molecules.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217154_247619820DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217256_358619820DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-121725_125619820DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318154_247619786DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318256_358619786DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-131825_125619786DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116154_247504705DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116256_358504705DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-111625_125504705DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217154_247532708DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217256_358532708DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-121725_125532708DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318154_247621822DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318256_358621822DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-131825_125621822DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217154_247533681DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217256_358533681DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-121725_125533681DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217154_247622770DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217256_358622770DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-121725_125622770DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116154_247505706DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116256_358505706DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-111625_125505706DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015154_247509710DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015256_358509710DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-101525_125509710DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318154_247622823DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318256_358622823DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-131825_125622823DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217487_495619820Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217565_567619820Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318487_495619786Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318565_567619786Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116487_495504705Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217487_495532708Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318487_495621822Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318565_567621822Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217487_495533681Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217487_495622770Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217565_567622770Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116487_495505706Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015487_495509710Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318487_495622823Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318565_567622823Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217161_178619820RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318161_178619786RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116161_178504705RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217161_178532708RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318161_178621822RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217161_178533681RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217161_178622770RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116161_178505706RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015161_178509710RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318161_178622823RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-121722_377619820Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-131822_377619786Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-111622_377504705Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-121722_377532708Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-131822_377621822Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-121722_377533681Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-121722_377622770Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-111622_377505706Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-101522_377509710Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-131822_377622823Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217378_398619820TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318378_398619786TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116378_398504705TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217378_398532708TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318378_398621822TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217378_398533681TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217378_398622770TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116378_398505706TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015378_398509710TransmembraneHelical
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318378_398622823TransmembraneHelical
TgeneAP1M1chr10:123256046chr19:16314270ENST00000291439+012168_42114424DomainMHD
TgeneAP1M1chr10:123256046chr19:16314270ENST00000444449+013168_42114436DomainMHD

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217481_770619820DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318481_770619786DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116481_770504705DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217481_770532708DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318481_770621822DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17154_247-163255DomainNote=Ig-like C2-type 2
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17256_358-163255DomainNote=Ig-like C2-type 3
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-1725_125-163255DomainNote=Ig-like C2-type 1
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17481_770-163255DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217481_770533681DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217481_770622770DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116481_770505706DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015481_770509710DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318481_770622823DomainProtein kinase
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116565_567504705Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217565_567532708Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17487_495-163255Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17565_567-163255Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217565_567533681Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116565_567505706Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015565_567509710Nucleotide bindingATP
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17161_178-163255RegionNote=Heparin-binding
HgeneFGFR2chr10:123256046chr19:16314270ENST00000346997-1217399_821619820Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000351936-1318399_821619786Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000356226-1116399_821504705Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000357555-1217399_821532708Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000358487-1318399_821621822Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-1722_377-163255Topological domainExtracellular
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17399_821-163255Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000360144-1217399_821533681Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369056-1217399_821622770Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369060-1116399_821505706Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000369061-1015399_821509710Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000457416-1318399_821622823Topological domainCytoplasmic
HgeneFGFR2chr10:123256046chr19:16314270ENST00000359354-17378_398-163255TransmembraneHelical


Top

FusionGeneSequence for FGFR2_AP1M1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FGFR2_ENST00000369061_chr10_123256046_-_AP1M1_ENST00000291439_chr19_16314270_+_919aa
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAIYC
IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDP
KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV
IVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKVLICRNYRGDVDMSEVEHFMPILMEKEEEGM
LSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLDELMDFGYPQTTDSKILQEYI
TQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLSGMPELRLGLNDKVLFDNTGR
GKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMIKAKSQFKRRSTANNVEIHIP
VPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYFTTSGIQVRYLKIIEKSGYQA

>In-frame_FGFR2_ENST00000346997_chr10_123256046_-_AP1M1_ENST00000291439_chr19_16314270_+_1029aa
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLS
STADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG
KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKVLICRNYRGDV
DMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYELLD
ELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRVFLS
GMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIEYMI
KAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEIPYF

>In-frame_FGFR2_ENST00000369056_chr10_123256046_-_AP1M1_ENST00000291439_chr19_16314270_+_1032aa
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGE
YLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVV
GGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPK
QQAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITT
RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMK
MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKVLICRNYR
GDVDMSEVEHFMPILMEKEEEGMLSPILAHGGVRFMWIKHNNLYLVATSKKNACVSLVFSFLYKVVQVFSEYFKELEEESIRDNFVIIYE
LLDELMDFGYPQTTDSKILQEYITQEGHKLETGAPRPPATVTNAVSWRSEGIKYRKNEVFLDVIESVNLLVSANGNVLRSEIVGSIKMRV
FLSGMPELRLGLNDKVLFDNTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIEKHSHSRIE
YMIKAKSQFKRRSTANNVEIHIPVPNDADSPKFKTTVGSVKWVPENSEIVWSIKSFPGGKEYLMRAHFGLPSVEAEDKEGKPPISVKFEI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FGFR2_ENST00000369061_chr10_123256046_-_AP1M1_ENST00000291439_chr19_16314270_+_2757nt
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGAT
ACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAG
TACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAAC
AAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGA
AACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGC
ATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAG
CCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACC
CCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCA
AAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGA
ATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTG
TCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTC
ATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGT
GTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAAGTG
CTCATCTGCCGGAACTACCGTGGCGACGTGGACATGTCAGAGGTGGAGCACTTCATGCCCATCCTGATGGAGAAGGAGGAGGAGGGGATG
CTGTCGCCCATCCTGGCCCACGGGGGGGTCCGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAACGCG
TGCGTGTCGCTGGTCTTTTCTTTCCTCTATAAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGGGAC
AACTTTGTTATCATCTACGAGCTGCTGGACGAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTACATC
ACTCAGGAAGGCCACAAGCTGGAAACAGGGGCCCCGCGGCCACCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATCAAG
TATCGGAAGAATGAGGTGTTCTTGGACGTCATCGAGTCTGTCAACCTCTTGGTCAGCGCCAACGGCAATGTCCTGCGCAGCGAGATCGTG
GGCTCCATCAAGATGCGAGTCTTCCTCTCGGGCATGCCCGAGCTGCGCCTGGGCCTCAACGACAAGGTCCTCTTTGACAACACGGGCCGC
GGCAAAAGCAAATCCGTGGAGCTGGAGGATGTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAATGACCGCACCATCTCCTTC
ATCCCACCCGACGGCGAGTTCGAGCTCATGTCCTACCGTCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATCGAGAAG
CACTCCCACAGCCGCATCGAGTACATGATCAAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATTCCC
GTGCCCAATGATGCCGACTCACCCAAGTTCAAGACGACGGTGGGGAGCGTTAAGTGGGTCCCCGAGAACAGCGAGATCGTGTGGTCCATC
AAGTCCTTCCCGGGCGGCAAGGAGTACCTGATGCGGGCCCACTTCGGCCTGCCTAGTGTGGAGGCCGAAGACAAGGAGGGCAAGCCCCCG
ATCAGTGTCAAGTTCGAGATCCCTTACTTCACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAGGCC

>In-frame_FGFR2_ENST00000346997_chr10_123256046_-_AP1M1_ENST00000291439_chr19_16314270_+_3087nt
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGAT
ACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAG
TACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAAC
AAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGA
AACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCCTCCACAGTGGTC
GGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAGAACGGCAGTAAA
TACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTTCTCTATATTCGG
AATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGGTTGACAGTTCTG
CCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGT
ATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAA
CGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAAGTGCTCATCTGCCGGAACTACCGTGGCGACGTG
GACATGTCAGAGGTGGAGCACTTCATGCCCATCCTGATGGAGAAGGAGGAGGAGGGGATGCTGTCGCCCATCCTGGCCCACGGGGGGGTC
CGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAACGCGTGCGTGTCGCTGGTCTTTTCTTTCCTCTAT
AAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGGGACAACTTTGTTATCATCTACGAGCTGCTGGAC
GAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTACATCACTCAGGAAGGCCACAAGCTGGAAACAGGG
GCCCCGCGGCCACCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATCAAGTATCGGAAGAATGAGGTGTTCTTGGACGTC
ATCGAGTCTGTCAACCTCTTGGTCAGCGCCAACGGCAATGTCCTGCGCAGCGAGATCGTGGGCTCCATCAAGATGCGAGTCTTCCTCTCG
GGCATGCCCGAGCTGCGCCTGGGCCTCAACGACAAGGTCCTCTTTGACAACACGGGCCGCGGCAAAAGCAAATCCGTGGAGCTGGAGGAT
GTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAATGACCGCACCATCTCCTTCATCCCACCCGACGGCGAGTTCGAGCTCATG
TCCTACCGTCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATCGAGAAGCACTCCCACAGCCGCATCGAGTACATGATC
AAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATTCCCGTGCCCAATGATGCCGACTCACCCAAGTTC
AAGACGACGGTGGGGAGCGTTAAGTGGGTCCCCGAGAACAGCGAGATCGTGTGGTCCATCAAGTCCTTCCCGGGCGGCAAGGAGTACCTG
ATGCGGGCCCACTTCGGCCTGCCTAGTGTGGAGGCCGAAGACAAGGAGGGCAAGCCCCCGATCAGTGTCAAGTTCGAGATCCCTTACTTC
ACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAGGCCCTGCCCTGGGTGCGTTATATCACGCAGAAT

>In-frame_FGFR2_ENST00000369056_chr10_123256046_-_AP1M1_ENST00000291439_chr19_16314270_+_3096nt
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGAT
ACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAG
TACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAAC
AAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGA
AACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCCTCCACAGTGGTC
GGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAGAACGGCAGTAAA
TACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCAGAAGTGCTGGCTCTGTTCAATGTG
ACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCTGCCTGGCTCACTGTCCTGCCAAAA
CAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCC
TGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACC
AAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACA
CGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGAT
AAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAG
GAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAG
ATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAA
GGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACC
TTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAAGTGCTCATCTGCCGGAACTACCGT
GGCGACGTGGACATGTCAGAGGTGGAGCACTTCATGCCCATCCTGATGGAGAAGGAGGAGGAGGGGATGCTGTCGCCCATCCTGGCCCAC
GGGGGGGTCCGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAACGCGTGCGTGTCGCTGGTCTTTTCT
TTCCTCTATAAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGGGACAACTTTGTTATCATCTACGAG
CTGCTGGACGAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTACATCACTCAGGAAGGCCACAAGCTG
GAAACAGGGGCCCCGCGGCCACCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATCAAGTATCGGAAGAATGAGGTGTTC
TTGGACGTCATCGAGTCTGTCAACCTCTTGGTCAGCGCCAACGGCAATGTCCTGCGCAGCGAGATCGTGGGCTCCATCAAGATGCGAGTC
TTCCTCTCGGGCATGCCCGAGCTGCGCCTGGGCCTCAACGACAAGGTCCTCTTTGACAACACGGGCCGCGGCAAAAGCAAATCCGTGGAG
CTGGAGGATGTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAATGACCGCACCATCTCCTTCATCCCACCCGACGGCGAGTTC
GAGCTCATGTCCTACCGTCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATCGAGAAGCACTCCCACAGCCGCATCGAG
TACATGATCAAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATTCCCGTGCCCAATGATGCCGACTCA
CCCAAGTTCAAGACGACGGTGGGGAGCGTTAAGTGGGTCCCCGAGAACAGCGAGATCGTGTGGTCCATCAAGTCCTTCCCGGGCGGCAAG
GAGTACCTGATGCGGGCCCACTTCGGCCTGCCTAGTGTGGAGGCCGAAGACAAGGAGGGCAAGCCCCCGATCAGTGTCAAGTTCGAGATC
CCTTACTTCACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAGGCCCTGCCCTGGGTGCGTTATATC


* Fusion transcript sequences (Full-length transcript).
>In-frame_FGFR2_ENST00000369061_chr10_123256046_-_AP1M1_ENST00000291439_chr19_16314270_+_3821nt
TGACTGCAGCAGCAGCGGCAGCGCCTCGGTTCCTGAGCCCACCGCAGGCTGAAGGCATTGCGCGTAGTCCATGCCCGTAGAGGAAGTGTG
CAGATGGGATTAACGTCCACATGGAGATATGGAAGAGGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTG
GTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATC
AGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCC
GGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGG
TGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGCG
CCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTG
GTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAACGTATC
CCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACAACACGCCTCTCT
TCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAGCTGACA
CTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTC
ACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATGATTGGG
AAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTC
CGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTCAAGGAC
TTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAAGTGCTCATCTGCCGGAACTACCGTGGCGACGTG
GACATGTCAGAGGTGGAGCACTTCATGCCCATCCTGATGGAGAAGGAGGAGGAGGGGATGCTGTCGCCCATCCTGGCCCACGGGGGGGTC
CGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAACGCGTGCGTGTCGCTGGTCTTTTCTTTCCTCTAT
AAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGGGACAACTTTGTTATCATCTACGAGCTGCTGGAC
GAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTACATCACTCAGGAAGGCCACAAGCTGGAAACAGGG
GCCCCGCGGCCACCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATCAAGTATCGGAAGAATGAGGTGTTCTTGGACGTC
ATCGAGTCTGTCAACCTCTTGGTCAGCGCCAACGGCAATGTCCTGCGCAGCGAGATCGTGGGCTCCATCAAGATGCGAGTCTTCCTCTCG
GGCATGCCCGAGCTGCGCCTGGGCCTCAACGACAAGGTCCTCTTTGACAACACGGGCCGCGGCAAAAGCAAATCCGTGGAGCTGGAGGAT
GTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAATGACCGCACCATCTCCTTCATCCCACCCGACGGCGAGTTCGAGCTCATG
TCCTACCGTCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATCGAGAAGCACTCCCACAGCCGCATCGAGTACATGATC
AAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATTCCCGTGCCCAATGATGCCGACTCACCCAAGTTC
AAGACGACGGTGGGGAGCGTTAAGTGGGTCCCCGAGAACAGCGAGATCGTGTGGTCCATCAAGTCCTTCCCGGGCGGCAAGGAGTACCTG
ATGCGGGCCCACTTCGGCCTGCCTAGTGTGGAGGCCGAAGACAAGGAGGGCAAGCCCCCGATCAGTGTCAAGTTCGAGATCCCTTACTTC
ACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAGGCCCTGCCCTGGGTGCGTTATATCACGCAGAAT
GGAGATTACCAGCTCCGGACCCAGTGAGGGGCTGTCGCAGCCAACACCCCGGCCTCGGGGCTCCTGGTGGCAGCACCAGGGGACACACCT
GCCAAACCCACCAGATGGAGGGGCCCTCCCTGGTCTCTGGCCACCCTCCCAGCCTCTGCCCAGGGACCCCTGCCTTCCCCAGGCCATCTG
CTCTGCCGTCGACACTCGTCTCAGAAGCCCCTTTCCCAGAAGAGGCTGGTCTTCAAGAAGTCTCGTTTCTTTGCCCCTGAAGTCAGTTTC
AGGGGAAGGATGTGAAATTTTTCCGTGTAGAGGTTACAGCCTTTTATGCTGTTGAGCTCCCAGGTACCAAAAAGCTTGGCCAACGCTTGC
CAGCCAGCCAGCTGCAGGTGGCATCTGCCACGAAGGAAGCGCCAGCCTCGCCAGGCCAGCAGGGGCGTCGTTTTGTTGCCATTTTGTTGA
ACGTTATGGGTTTATGGGTGTTCCTGGAACTTGTCTTTGTGCATTCGTTGCTGTTTGTGTTACCCTCACTGTCCCCATGTCCCACCCACG
TCCTACGGCACTCAGGAAGCACTTGGTGAGGACGAGCCCTCACCCTTCTTGTCTTCCTTCCCGGCAGCGCCCGCAGCGGGCCATTTACAC
GTCGAGGCTGGCACCTGGCGCGCTCGGGGGCCACTGTAGCGTCTGCCTGCTCCCTGGACTCGCAGGCCTCGCCTGTGGCGCCTTCCCAGG
GCCAGCCTGGGTCACGAGATGCTGTCACTCAGCCAGATCAGTATTGACCCACCAGGGGAGGTGGGGTTTGGTGAGAGACGCCAGCCTCAG
ACTTTTTCCCACTGAGGGTCCAGAGAGCGGGGCCACGTGTCACCCACGTCTGCGCTTGGTCACCCGTCCTCCCCACCCTGTGTGTGTTTA

>In-frame_FGFR2_ENST00000346997_chr10_123256046_-_AP1M1_ENST00000291439_chr19_16314270_+_4013nt
GGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGGCCCTCCTTCAGT
TTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAG
TCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAACAATAGGACAGTG
CTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAA
ACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGATTTTGTCAGTGAG
AACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAG
TTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCATCGCATTGGAGGC
TACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAA
TACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTGCCGGCAAATGCC
TCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAG
AACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACGGACAAAGAGATTGAGGTT
CTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATATACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGG
TTGACAGTTCTGCCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTACTGCATAGGGGTCTTC
TTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCAC
AAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAACACCCCGCTGGTGAGGATAACA
ACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGA
GATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTGGGAATTGACAAAGACAAGCCC
AAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATG
AAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTATGTCATAGTTGAGTATGCCTCT
AAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATG
ACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAAGTGCTCATCTGCCGGAACTAC
CGTGGCGACGTGGACATGTCAGAGGTGGAGCACTTCATGCCCATCCTGATGGAGAAGGAGGAGGAGGGGATGCTGTCGCCCATCCTGGCC
CACGGGGGGGTCCGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAACGCGTGCGTGTCGCTGGTCTTT
TCTTTCCTCTATAAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGGGACAACTTTGTTATCATCTAC
GAGCTGCTGGACGAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTACATCACTCAGGAAGGCCACAAG
CTGGAAACAGGGGCCCCGCGGCCACCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATCAAGTATCGGAAGAATGAGGTG
TTCTTGGACGTCATCGAGTCTGTCAACCTCTTGGTCAGCGCCAACGGCAATGTCCTGCGCAGCGAGATCGTGGGCTCCATCAAGATGCGA
GTCTTCCTCTCGGGCATGCCCGAGCTGCGCCTGGGCCTCAACGACAAGGTCCTCTTTGACAACACGGGCCGCGGCAAAAGCAAATCCGTG
GAGCTGGAGGATGTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAATGACCGCACCATCTCCTTCATCCCACCCGACGGCGAG
TTCGAGCTCATGTCCTACCGTCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATCGAGAAGCACTCCCACAGCCGCATC
GAGTACATGATCAAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATTCCCGTGCCCAATGATGCCGAC
TCACCCAAGTTCAAGACGACGGTGGGGAGCGTTAAGTGGGTCCCCGAGAACAGCGAGATCGTGTGGTCCATCAAGTCCTTCCCGGGCGGC
AAGGAGTACCTGATGCGGGCCCACTTCGGCCTGCCTAGTGTGGAGGCCGAAGACAAGGAGGGCAAGCCCCCGATCAGTGTCAAGTTCGAG
ATCCCTTACTTCACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAGGCCCTGCCCTGGGTGCGTTAT
ATCACGCAGAATGGAGATTACCAGCTCCGGACCCAGTGAGGGGCTGTCGCAGCCAACACCCCGGCCTCGGGGCTCCTGGTGGCAGCACCA
GGGGACACACCTGCCAAACCCACCAGATGGAGGGGCCCTCCCTGGTCTCTGGCCACCCTCCCAGCCTCTGCCCAGGGACCCCTGCCTTCC
CCAGGCCATCTGCTCTGCCGTCGACACTCGTCTCAGAAGCCCCTTTCCCAGAAGAGGCTGGTCTTCAAGAAGTCTCGTTTCTTTGCCCCT
GAAGTCAGTTTCAGGGGAAGGATGTGAAATTTTTCCGTGTAGAGGTTACAGCCTTTTATGCTGTTGAGCTCCCAGGTACCAAAAAGCTTG
GCCAACGCTTGCCAGCCAGCCAGCTGCAGGTGGCATCTGCCACGAAGGAAGCGCCAGCCTCGCCAGGCCAGCAGGGGCGTCGTTTTGTTG
CCATTTTGTTGAACGTTATGGGTTTATGGGTGTTCCTGGAACTTGTCTTTGTGCATTCGTTGCTGTTTGTGTTACCCTCACTGTCCCCAT
GTCCCACCCACGTCCTACGGCACTCAGGAAGCACTTGGTGAGGACGAGCCCTCACCCTTCTTGTCTTCCTTCCCGGCAGCGCCCGCAGCG
GGCCATTTACACGTCGAGGCTGGCACCTGGCGCGCTCGGGGGCCACTGTAGCGTCTGCCTGCTCCCTGGACTCGCAGGCCTCGCCTGTGG
CGCCTTCCCAGGGCCAGCCTGGGTCACGAGATGCTGTCACTCAGCCAGATCAGTATTGACCCACCAGGGGAGGTGGGGTTTGGTGAGAGA
CGCCAGCCTCAGACTTTTTCCCACTGAGGGTCCAGAGAGCGGGGCCACGTGTCACCCACGTCTGCGCTTGGTCACCCGTCCTCCCCACCC

>In-frame_FGFR2_ENST00000369056_chr10_123256046_-_AP1M1_ENST00000291439_chr19_16314270_+_4034nt
GGACCGGGGATTGGTACCGTAACCATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTGGCCCGG
CCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACCAAATACCAAATCTCTCAACCAGAAGTGTACGTGGCT
GCGCCAGGGGAGTCGCTAGAGGTGCGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGGCCCAAC
AATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGAGACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACT
GTAGACAGTGAAACTTGGTACTTCATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCGGAAGAT
TTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAAAAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCC
AACACTGTCAAGTTTCGCTGCCCAGCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAGGAGCAT
CGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGTGTGGTCCCATCTGACAAGGGAAATTATACCTGTGTA
GTGGAGAATGAATACGGGTCCATCAATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCCGGACTG
CCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTTTACAGTGATGCCCAGCCCCACATCCAGTGGATCAAG
CACGTGGAAAAGAACGGCAGTAAATACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGCACTCGGGGATAAATAGTTCCAATGCA
GAAGTGCTGGCTCTGTTCAATGTGACCGAGGCGGATGCTGGGGAATATATATGTAAGGTCTCCAATTATATAGGGCAGGCCAACCAGTCT
GCCTGGCTCACTGTCCTGCCAAAACAGCAAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATTTAC
TGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATGAAGAACACGACCAAGAAGCCAGACTTCAGCAGC
CAGCCGGCTGTGCACAAGCTGACCAAACGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCCAAC
ACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTGGCAGGGGTCTCCGAGTATGAACTTCCAGAGGAC
CCAAAATGGGAGTTTCCAAGAGATAAGCTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCAGTG
GGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAAGATGATGCCACAGAGAAAGACCTTTCTGATCTG
GTGTCAGAGATGGAGATGATGAAGATGATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTCTAT
GTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGGCCACCCGGGATGGAGTACTCCTATGACATTAAC
CGTGTTCCTGAGGAGCAGATGACCTTCAAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAAAAA
GTGCTCATCTGCCGGAACTACCGTGGCGACGTGGACATGTCAGAGGTGGAGCACTTCATGCCCATCCTGATGGAGAAGGAGGAGGAGGGG
ATGCTGTCGCCCATCCTGGCCCACGGGGGGGTCCGTTTCATGTGGATCAAACACAACAACCTGTATCTGGTTGCCACATCCAAGAAGAAC
GCGTGCGTGTCGCTGGTCTTTTCTTTCCTCTATAAGGTGGTGCAGGTGTTTTCCGAGTACTTCAAGGAGCTGGAGGAGGAGAGCATCCGG
GACAACTTTGTTATCATCTACGAGCTGCTGGACGAGCTCATGGACTTCGGCTACCCCCAGACCACCGACAGCAAGATCCTGCAGGAGTAC
ATCACTCAGGAAGGCCACAAGCTGGAAACAGGGGCCCCGCGGCCACCAGCCACCGTCACCAACGCGGTGTCCTGGCGGTCCGAAGGCATC
AAGTATCGGAAGAATGAGGTGTTCTTGGACGTCATCGAGTCTGTCAACCTCTTGGTCAGCGCCAACGGCAATGTCCTGCGCAGCGAGATC
GTGGGCTCCATCAAGATGCGAGTCTTCCTCTCGGGCATGCCCGAGCTGCGCCTGGGCCTCAACGACAAGGTCCTCTTTGACAACACGGGC
CGCGGCAAAAGCAAATCCGTGGAGCTGGAGGATGTGAAGTTCCACCAGTGTGTGCGGCTATCACGCTTCGAGAATGACCGCACCATCTCC
TTCATCCCACCCGACGGCGAGTTCGAGCTCATGTCCTACCGTCTCAACACCCACGTCAAGCCTTTGATATGGATCGAGTCGGTGATCGAG
AAGCACTCCCACAGCCGCATCGAGTACATGATCAAGGCCAAAAGCCAGTTCAAGCGGCGGTCAACAGCCAACAACGTGGAGATCCACATT
CCCGTGCCCAATGATGCCGACTCACCCAAGTTCAAGACGACGGTGGGGAGCGTTAAGTGGGTCCCCGAGAACAGCGAGATCGTGTGGTCC
ATCAAGTCCTTCCCGGGCGGCAAGGAGTACCTGATGCGGGCCCACTTCGGCCTGCCTAGTGTGGAGGCCGAAGACAAGGAGGGCAAGCCC
CCGATCAGTGTCAAGTTCGAGATCCCTTACTTCACTACCTCCGGCATCCAGGTGCGCTACCTGAAGATCATTGAGAAGAGTGGGTACCAG
GCCCTGCCCTGGGTGCGTTATATCACGCAGAATGGAGATTACCAGCTCCGGACCCAGTGAGGGGCTGTCGCAGCCAACACCCCGGCCTCG
GGGCTCCTGGTGGCAGCACCAGGGGACACACCTGCCAAACCCACCAGATGGAGGGGCCCTCCCTGGTCTCTGGCCACCCTCCCAGCCTCT
GCCCAGGGACCCCTGCCTTCCCCAGGCCATCTGCTCTGCCGTCGACACTCGTCTCAGAAGCCCCTTTCCCAGAAGAGGCTGGTCTTCAAG
AAGTCTCGTTTCTTTGCCCCTGAAGTCAGTTTCAGGGGAAGGATGTGAAATTTTTCCGTGTAGAGGTTACAGCCTTTTATGCTGTTGAGC
TCCCAGGTACCAAAAAGCTTGGCCAACGCTTGCCAGCCAGCCAGCTGCAGGTGGCATCTGCCACGAAGGAAGCGCCAGCCTCGCCAGGCC
AGCAGGGGCGTCGTTTTGTTGCCATTTTGTTGAACGTTATGGGTTTATGGGTGTTCCTGGAACTTGTCTTTGTGCATTCGTTGCTGTTTG
TGTTACCCTCACTGTCCCCATGTCCCACCCACGTCCTACGGCACTCAGGAAGCACTTGGTGAGGACGAGCCCTCACCCTTCTTGTCTTCC
TTCCCGGCAGCGCCCGCAGCGGGCCATTTACACGTCGAGGCTGGCACCTGGCGCGCTCGGGGGCCACTGTAGCGTCTGCCTGCTCCCTGG
ACTCGCAGGCCTCGCCTGTGGCGCCTTCCCAGGGCCAGCCTGGGTCACGAGATGCTGTCACTCAGCCAGATCAGTATTGACCCACCAGGG
GAGGTGGGGTTTGGTGAGAGACGCCAGCCTCAGACTTTTTCCCACTGAGGGTCCAGAGAGCGGGGCCACGTGTCACCCACGTCTGCGCTT


Top

FusionGenePPI for FGFR2_AP1M1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGFR2FGF1, FGFR2, FGF7, FGF10, PIK3R1, ITGA5, STAT3, PGR, STAT5A, STAT5B, NEDD4, FRS2, CBL, LYN, FYN, HGS, APP, PPM1A, TSPAN3, C8orf74, BEX1, BEX2, ERRFI1, GLCE, HOXC6, MTA3, PDLIM2, RASL10B, RHOBTB2, S100A14, TFF1, FGF5, FGF23, FGF8, PLCG1, FGF2, FGF3, FGF6, FGF9, FGF17, PVRL1, BRAF, MAP3K1, PTPN6, PTPN11, PTPN12, PTPRR, FGFR3, FGFR1, SNX24, GAPVD1, SNX22, UBE4A, IP6K1, RPS6KA3, IFFO2, TMEM30B, DNAJC30, XPR1, GOLGA3, KIDINS220, BCL11A, CEP295, CD44, RPS6KA2, LRRIQ1, RPS6KA1, LITAF, MRAP2, SDC2, FCGRT, SIGLECL1, RAET1E, FAM171B, CHERP, U2SURP, SLC9A6, TIMP1, CCDC120, CD83, PKP4, UBXN4, CTDSP1, CTDSPL, DUSP14, MTMR3AP1M1VAMP4, TIFA, FXR2, AP2B1, MTF1, RUNDC3A, DVL2, HNRNPC, LDOC1, ZBTB8A, AP1G1, SELP, KIF13A, AP1B1, TGOLN2, AP1S2, AP1S1, ALB, EGFR, HEXIM1, DCP2, GPRASP2, PHC2, ETV6, ZBTB14, DZIP3, TNIP1, IKZF1, SDCCAG3, ZBTB43, ZBTB44, HOOK2, LZTS2, PNMA5, SSX2IP, KRT40, FAM9B, CEP57L1, KRTAP10-7, KRTAP10-3, CORO7, BRCA1, MPZL2, NECAP2, SPACA1, CA14, DCPS, PRKAB1, RNASEH2A, RNASEH2B, UBA1, NTRK1, SRPK2, XPO1, NCBP1, GTSE1, SLC2A4, FBXO4, RNF19B, CPD, TLR2, DLD, UBE2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FGFR2_AP1M1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGFR2P21802DB00039PaliferminFibroblast growth factor receptor 2biotechapproved
HgeneFGFR2P21802DB08896RegorafenibFibroblast growth factor receptor 2small moleculeapproved
HgeneFGFR2P21802DB09079NintedanibFibroblast growth factor receptor 2small moleculeapproved
HgeneFGFR2P21802DB01109HeparinFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB08901PonatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB09078LenvatinibFibroblast growth factor receptor 2small moleculeapproved|investigational
HgeneFGFR2P21802DB01041ThalidomideFibroblast growth factor receptor 2small moleculeapproved|investigational|withdrawn

Top

RelatedDiseases for FGFR2_AP1M1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR2C2931196Craniofacial dysostosis type 121ORPHANET;UNIPROT
HgeneFGFR2C0220658Pfeiffer Syndrome10UNIPROT
HgeneFGFR2C0001193Apert syndrome8ORPHANET;UNIPROT
HgeneFGFR2C1510455Acrocephalosyndactylia4CTD_human
HgeneFGFR2C0010278Craniosynostosis3CTD_human;HPO
HgeneFGFR2C0036341Schizophrenia3PSYGENET
HgeneFGFR2C0376634Craniofacial Abnormalities3CTD_human
HgeneFGFR2C1458155Mammary Neoplasms3CTD_human
HgeneFGFR2C0011570Mental Depression2PSYGENET
HgeneFGFR2C0011581Depressive disorder2PSYGENET
HgeneFGFR2C0038356Stomach Neoplasms2CTD_human
HgeneFGFR2C1865070SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION2CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C0003090Ankylosis1CTD_human
HgeneFGFR2C0005586Bipolar Disorder1PSYGENET
HgeneFGFR2C0008924Cleft Lip1CTD_human
HgeneFGFR2C0008925Cleft Palate1CTD_human;HPO
HgeneFGFR2C0010273Craniofacial Dysostosis1CTD_human;HPO
HgeneFGFR2C0014170Endometrial Neoplasms1CTD_human
HgeneFGFR2C0018553Hamartoma Syndrome, Multiple1CTD_human
HgeneFGFR2C0023890Liver Cirrhosis1CTD_human
HgeneFGFR2C0024121Lung Neoplasms1CTD_human
HgeneFGFR2C0026613Motor Skills Disorders1CTD_human
HgeneFGFR2C0033975Psychotic Disorders1PSYGENET
HgeneFGFR2C0037268Skin Abnormalities1CTD_human
HgeneFGFR2C0037274Dermatologic disorders1CTD_human
HgeneFGFR2C0040427Tooth Abnormalities1CTD_human
HgeneFGFR2C0080178Spina Bifida1CTD_human
HgeneFGFR2C0206698Cholangiocarcinoma1CTD_human
HgeneFGFR2C0206762Limb Deformities, Congenital1CTD_human
HgeneFGFR2C0265269Lacrimoauriculodentodigital syndrome1CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C0349204Nonorganic psychosis1PSYGENET
HgeneFGFR2C1450010Plagiocephaly, Nonsynostotic1CTD_human;HPO
HgeneFGFR2C1852406Cutis Gyrata Syndrome of Beare And Stevenson1CTD_human;ORPHANET;UNIPROT
HgeneFGFR2C2350233Antley-Bixler Syndrome Phenotype1CTD_human
HgeneFGFR2C3281247BENT BONE DYSPLASIA SYNDROME1ORPHANET;UNIPROT
HgeneFGFR2C3714756Intellectual Disability1CTD_human;HPO