FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13386

FusionGeneSummary for FGFR1_ADAM18

check button Fusion gene summary
Fusion gene informationFusion gene name: FGFR1_ADAM18
Fusion gene ID: 13386
HgeneTgene
Gene symbol

FGFR1

ADAM18

Gene ID

2260

8749

Gene namefibroblast growth factor receptor 1ADAM metallopeptidase domain 18
SynonymsBFGFR|CD331|CEK|ECCL|FGFBR|FGFR-1|FLG|FLT-2|FLT2|HBGFR|HH2|HRTFDS|KAL2|N-SAM|OGD|bFGF-R-1ADAM27|tMDCIII
Cytomap

8p11.23

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgrdisintegrin and metalloproteinase domain-containing protein 18a disintegrin and metalloproteinase domain 18transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
Modification date2018052720180329
UniProtAcc

P11362

Q9Y3Q7

Ensembl transtripts involved in fusion geneENST00000425967, ENST00000397091, 
ENST00000447712, ENST00000341462, 
ENST00000532791, ENST00000397113, 
ENST00000356207, ENST00000335922, 
ENST00000326324, ENST00000397103, 
ENST00000397108, ENST00000496629, 
ENST00000265707, ENST00000379866, 
ENST00000520772, ENST00000541111, 
ENST00000523755, 
Fusion gene scores* DoF score11 X 9 X 5=4956 X 5 X 5=150
# samples 126
** MAII scorelog2(12/495*10)=-2.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGFR1 [Title/Abstract] AND ADAM18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR1

GO:0008284

positive regulation of cell proliferation

8663044

HgeneFGFR1

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

HgeneFGFR1

GO:0010863

positive regulation of phospholipase C activity

18480409

HgeneFGFR1

GO:0018108

peptidyl-tyrosine phosphorylation

8622701|18480409

HgeneFGFR1

GO:0043406

positive regulation of MAP kinase activity

8622701|18480409

HgeneFGFR1

GO:0046777

protein autophosphorylation

8622701

HgeneFGFR1

GO:2000546

positive regulation of endothelial cell chemotaxis to fibroblast growth factor

21885851


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A574-01AFGFR1chr8

38314874

-ADAM18chr8

39463826

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000425967ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000425967ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000425967ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000425967ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000425967ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397091ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397091ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397091ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000397091ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000397091ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000447712ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000447712ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000447712ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000447712ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000447712ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000341462ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000341462ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000341462ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000341462ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000341462ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000532791ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000532791ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000532791ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000532791ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000532791ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397113ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397113ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397113ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000397113ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000397113ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000356207ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000356207ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000356207ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000356207ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000356207ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5UTR-3CDSENST00000335922ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5UTR-3CDSENST00000335922ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5UTR-3CDSENST00000335922ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5UTR-5UTRENST00000335922ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5UTR-intronENST00000335922ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000326324ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000326324ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000326324ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000326324ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000326324ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
In-frameENST00000397103ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
In-frameENST00000397103ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
In-frameENST00000397103ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000397103ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000397103ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397108ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397108ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
Frame-shiftENST00000397108ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-5UTRENST00000397108ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
5CDS-intronENST00000397108ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+
intron-3CDSENST00000496629ENST00000265707FGFR1chr8

38314874

-ADAM18chr8

39463826

+
intron-3CDSENST00000496629ENST00000379866FGFR1chr8

38314874

-ADAM18chr8

39463826

+
intron-3CDSENST00000496629ENST00000520772FGFR1chr8

38314874

-ADAM18chr8

39463826

+
intron-5UTRENST00000496629ENST00000541111FGFR1chr8

38314874

-ADAM18chr8

39463826

+
intron-intronENST00000496629ENST00000523755FGFR1chr8

38314874

-ADAM18chr8

39463826

+

Top

FusionProtFeatures for FGFR1_ADAM18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR1

P11362

ADAM18

Q9Y3Q7

Sperm surface membrane protein that may be involved inspermatogenesis and fertilization. This is a non catalyticmetalloprotease-like protein (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FGFR1_ADAM18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_FGFR1_ENST00000397103_chr8_38314874_-_ADAM18_ENST00000265707_chr8_39463826_+_726aa
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDDLHHYNXWTTLHSTSRKTIILTPELFGLYIXXNWIFAFCVSIFYDALPLPRICCRISKF
ICDTQYMFWSQGISPVXKYQLWNXTSRIFSKIXAYNLSNEKXXSKCIHFSSKLQSYLAERPALQSSFKLTDKKSFKTITPISGNIHYSGK
SFVXLYGIXNDGCNTKNCPGYWACQHYVYPVQIDCYTVFLGIVVKXKPDFHQWGCXXYITKIFGMETGLSHPTAPXHSILTCLQETSXIC
GSNISWHCMQXKLXCRYCYVSRCNRFGGIFGYYSSTAWPXCRINIXXHHSVFLSESYMHHESXSSECQWXKDFXQLQHARLXIFCFKIXD
XMPSEAFKFATITSKSTSVWXWDFGIQXRMXLWXXKXMSIXEVLXLXHMXTEGLSKMWFWTMLYIKVXVVNSRHSMXKEYXSRVXFYRVL
QWNLXXLCSXHLCIEWPFVQVGNCLLLXRTMSNYXXPVCQDIWKRCSRCSICLFXRSXFSAXKIXKLWFXKFTTITLXTEGCSLWKISLC
SATXKCXXKXRSIYSLFIYSRPCMCIYSHWFLHEIRWNRQCLCGXWHHVWSRNVLCKXNLQKSSFNGIXLXCHHKMQRERDMXXFWXLSM
LPWTXTSRLXIPVWFPRGXYXXWKFSEIWXLLYXKRLQYTLEQLVYSEFLHFSAVFHSFHHCDLXKKXNKXIMXQRECRVXSXFIRCIRK

>In-frame_FGFR1_ENST00000397103_chr8_38314874_-_ADAM18_ENST00000379866_chr8_39463826_+_702aa
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDDLHHYNXWTTLHSTSRKTIILTPELFGLYIXXNWIFAFCVSIFYDALPLPRICCRISKF
ICDTQYMFWSQGISPVXKYQLWNXTSRIFSKIXAYNLSNEKXXSKCIHFSSKLQSYLAERPALQSSFKLTDKKSFKTITPISGNIHYSGK
SFDVYPVQIDCYTVFLGIVVKXKPDFHQWGCXXYITKIFGMETGLSHPTAPXHSILTCLQETSXICGSNISWHCMQXKLXCRYCYVSRCN
RFGGIFGYYSSTAWPXCRINIXXHHSVFLSESYMHHESXSSECQWXKDFXQLQHARLXIFCFKIXDXMPSEAFKFATITSKSTSVWXWDF
GIQXRMXLWXXKXMSIXEVLXLXHMXTEGLSKMWFWTMLYIKVXVVNSRHSMXKEYXSRVXFYRVLQWNLXXLCSXHLCIEWPFVQVGNC
LLLXRTMSNYXXPVCQDIWKRCSRCSICLFXRSXFSAXKIXKLWFXKFTTITLXTEGCSLWKISLCSATXKCXXKXRSIYSLFIYSRPCM
CIYSHWFLHEIRWNRQCLCGXWHHVWSRNVLCKXNLQKSSFNGIXLXCHHKMQRERDMXXFWXLSMLPWTXTSRLXIPVWFPRGXYXXWK

>In-frame_FGFR1_ENST00000397103_chr8_38314874_-_ADAM18_ENST00000520772_chr8_39463826_+_169aa
MWSWKCLLFWAVLVTATLCTARPSPTLPEQDDLHHYNXWTTLHSTSRKTIILTPELFGLYIXXNWIFAFCVSIFYDALPLPRICCRISKF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_FGFR1_ENST00000397103_chr8_38314874_-_ADAM18_ENST00000265707_chr8_39463826_+_2179nt
ATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAA
GATGATTTACATCATTACAATTGATGGACAACCTTACACTCTACATCTCGGAAAACAATCATTCTTACCCCAGAACTTTTTGGTTTATAC
ATATAATGAAACTGGATCTTTGCATTCTGTGTCTCCATATTTTATGATGCATTGCCATTACCAAGGATATGCTGCCGAATTTCCAAATTC
ATTTGTGACACTCAGTATATGTTCTGGTCTCAGGGGATTTCTCCAGTTTGAAAATATCAGTTATGGAATTGAACCAGTAGAATCTTCAGC
AAGATTTGAGCATATAATTTATCAAATGAAAAATAATGATCCAAATGTATCCATTTTAGCAGTAAATTACAGTCATATTTGGCAGAAAGA
CCAGCCCTACAAAGTTCCTTTAAACTCACAGATAAAAAATCTTTCAAAACTATTACCCCAATATCTGGAAATATACATTATAGTGGAAAA
AGCTTTGTATGATTATATGGGATCTGAAATGATGGCTGTAACACAAAAAATTGTCCAGGTTATTGGGCTTGTCAACACTATGTTTACCCA
GTTCAAATTGACTGTTATACTGTCTTCCTTGGAATTGTGGTCAAATGAAAACCAGATTTCCACCAGTGGGGATGCTGATGATATATTACA
AAGATTTTTGGCATGGAAACGGGACTATCTCATCCTACGGCCCCATGACATAGCATACTTACTTGTTTACAGGAAACATCCTAAATATGT
GGGAGCAACATTTCCTGGCACTGTATGCAATAAAAGCTATGATGCAGGTATTGCTATGTATCCAGATGCAATAGGTTTGGAGGGATTTTC
GGTTATTATAGCTCAACTGCTTGGCCTTAATGTAGGATTAACATATGATGACATCACTCAGTGTTTCTGTCTGAGAGCTACATGCATCAT
GAATCATGAAGCAGTGAGTGCCAGTGGTAGAAAGATTTTTAGCAACTGCAGCATGCACGACTATAGATATTTTGTTTCAAAATTTGAGAC
TAAATGCCTTCAGAAGCTTTCAAATTTGCAACCATTACATCAAAATCAACCAGTGTGTGGTAATGGGATTTTGGAATCCAATGAAGAATG
TGACTGTGGTAATAAAAATGAATGTCAATTTAAGAAGTGCTGTGATTATAACACATGTAAACTGAAGGGCTCAGTAAAATGTGGTTCTGG
ACCATGTTGTACATCAAAGTGTGAGTTGTCAATAGCAGGCACTCCATGTAGAAAGAGTATTGATCCAGAGTGTGATTTTACAGAGTACTG
CAATGGAACCTCTAGTAATTGTGTTCCTGACACTTATGCATTGAATGGCCGTTTGTGCAAGTTGGGAACTGCCTATTGCTATAACGGACA
ATGTCAAACTACTGATAACCAGTGTGCCAAGATATTTGGAAAAGGTGCTCAAGGTGCTCCATTTGCCTGTTTTAAAGAAGTTAATTCTCT
GCATGAAAGATCTGAAAACTGTGGTTTTAAAAATTCACAACCATTACCTTGTGAACGGAAGGATGTTCTCTGTGGAAAATTAGCTTGTGT
TCAGCCACATAAAAATGCTAATAAAAGTGACGCTCAATCTACAGTTTATTCATATATTCAAGACCATGTATGTGTATCTATAGCCACTGG
TTCCTCCATGAGATCAGATGGAACAGACAATGCCTATGTGGCTGATGGCACCATGTGTGGTCCAGAAATGTACTGTGTAAATAAAACCTG
CAGAAAAGTTCATTTAATGGGATATAACTGTAATGCCACCACAAAATGCAAAGGGAAAGGGATATGTAATAATTTTGGTAATTGTCAATG
CTTCCCTGGACATAGACCTCCAGATTGTAAATTCCAGTTTGGTTCCCCAGGGGGTAGTATTGATGATGGAAATTTTCAGAAATCTGGTGA
CTTTTATACTGAAAAAGGCTACAATACACACTGGAACAACTGGTTTATTCTGAGTTTCTGCATTTTTCTGCCGTTTTTCATAGTTTTCAC
CACTGTGATCTTTAAAAGAAATGAAATAAGTAAATCATGTAACAGAGAGAATGCAGAGTATAATCGTAATTCATCCGTTGTATCAGAAAG

>In-frame_FGFR1_ENST00000397103_chr8_38314874_-_ADAM18_ENST00000379866_chr8_39463826_+_2107nt
ATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAA
GATGATTTACATCATTACAATTGATGGACAACCTTACACTCTACATCTCGGAAAACAATCATTCTTACCCCAGAACTTTTTGGTTTATAC
ATATAATGAAACTGGATCTTTGCATTCTGTGTCTCCATATTTTATGATGCATTGCCATTACCAAGGATATGCTGCCGAATTTCCAAATTC
ATTTGTGACACTCAGTATATGTTCTGGTCTCAGGGGATTTCTCCAGTTTGAAAATATCAGTTATGGAATTGAACCAGTAGAATCTTCAGC
AAGATTTGAGCATATAATTTATCAAATGAAAAATAATGATCCAAATGTATCCATTTTAGCAGTAAATTACAGTCATATTTGGCAGAAAGA
CCAGCCCTACAAAGTTCCTTTAAACTCACAGATAAAAAATCTTTCAAAACTATTACCCCAATATCTGGAAATATACATTATAGTGGAAAA
AGCTTTGATGTTTACCCAGTTCAAATTGACTGTTATACTGTCTTCCTTGGAATTGTGGTCAAATGAAAACCAGATTTCCACCAGTGGGGA
TGCTGATGATATATTACAAAGATTTTTGGCATGGAAACGGGACTATCTCATCCTACGGCCCCATGACATAGCATACTTACTTGTTTACAG
GAAACATCCTAAATATGTGGGAGCAACATTTCCTGGCACTGTATGCAATAAAAGCTATGATGCAGGTATTGCTATGTATCCAGATGCAAT
AGGTTTGGAGGGATTTTCGGTTATTATAGCTCAACTGCTTGGCCTTAATGTAGGATTAACATATGATGACATCACTCAGTGTTTCTGTCT
GAGAGCTACATGCATCATGAATCATGAAGCAGTGAGTGCCAGTGGTAGAAAGATTTTTAGCAACTGCAGCATGCACGACTATAGATATTT
TGTTTCAAAATTTGAGACTAAATGCCTTCAGAAGCTTTCAAATTTGCAACCATTACATCAAAATCAACCAGTGTGTGGTAATGGGATTTT
GGAATCCAATGAAGAATGTGACTGTGGTAATAAAAATGAATGTCAATTTAAGAAGTGCTGTGATTATAACACATGTAAACTGAAGGGCTC
AGTAAAATGTGGTTCTGGACCATGTTGTACATCAAAGTGTGAGTTGTCAATAGCAGGCACTCCATGTAGAAAGAGTATTGATCCAGAGTG
TGATTTTACAGAGTACTGCAATGGAACCTCTAGTAATTGTGTTCCTGACACTTATGCATTGAATGGCCGTTTGTGCAAGTTGGGAACTGC
CTATTGCTATAACGGACAATGTCAAACTACTGATAACCAGTGTGCCAAGATATTTGGAAAAGGTGCTCAAGGTGCTCCATTTGCCTGTTT
TAAAGAAGTTAATTCTCTGCATGAAAGATCTGAAAACTGTGGTTTTAAAAATTCACAACCATTACCTTGTGAACGGAAGGATGTTCTCTG
TGGAAAATTAGCTTGTGTTCAGCCACATAAAAATGCTAATAAAAGTGACGCTCAATCTACAGTTTATTCATATATTCAAGACCATGTATG
TGTATCTATAGCCACTGGTTCCTCCATGAGATCAGATGGAACAGACAATGCCTATGTGGCTGATGGCACCATGTGTGGTCCAGAAATGTA
CTGTGTAAATAAAACCTGCAGAAAAGTTCATTTAATGGGATATAACTGTAATGCCACCACAAAATGCAAAGGGAAAGGGATATGTAATAA
TTTTGGTAATTGTCAATGCTTCCCTGGACATAGACCTCCAGATTGTAAATTCCAGTTTGGTTCCCCAGGGGGTAGTATTGATGATGGAAA
TTTTCAGAAATCTGGTGACTTTTATACTGAAAAAGGCTACAATACACACTGGAACAACTGGTTTATTCTGAGTTTCTGCATTTTTCTGCC
GTTTTTCATAGTTTTCACCACTGTGATCTTTAAAAGAAATGAAATAAGTAAATCATGTAACAGAGAGAATGCAGAGTATAATCGTAATTC

>In-frame_FGFR1_ENST00000397103_chr8_38314874_-_ADAM18_ENST00000520772_chr8_39463826_+_508nt
ATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCTGTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAA
GATGATTTACATCATTACAATTGATGGACAACCTTACACTCTACATCTCGGAAAACAATCATTCTTACCCCAGAACTTTTTGGTTTATAC
ATATAATGAAACTGGATCTTTGCATTCTGTGTCTCCATATTTTATGATGCATTGCCATTACCAAGGATATGCTGCCGAATTTCCAAATTC
ATTTGTGACACTCAGTATATGTTCTGGTCTCAGGGGATTTCTCCAGTTTGAAAATATCAGTTATGGAATTGAACCAGTAGAATCTTCAGC
AAGATTTGAGCATATAATTTATCAAATGAAAAATAATGATCCAAATGTATCCATTTTAGCAGTAAATTACAGTCATATTTGGCAGAAAGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_FGFR1_ENST00000397103_chr8_38314874_-_ADAM18_ENST00000265707_chr8_39463826_+_2359nt
GTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCT
GTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGATTTACATCATTACAATTGATGGACAACC
TTACACTCTACATCTCGGAAAACAATCATTCTTACCCCAGAACTTTTTGGTTTATACATATAATGAAACTGGATCTTTGCATTCTGTGTC
TCCATATTTTATGATGCATTGCCATTACCAAGGATATGCTGCCGAATTTCCAAATTCATTTGTGACACTCAGTATATGTTCTGGTCTCAG
GGGATTTCTCCAGTTTGAAAATATCAGTTATGGAATTGAACCAGTAGAATCTTCAGCAAGATTTGAGCATATAATTTATCAAATGAAAAA
TAATGATCCAAATGTATCCATTTTAGCAGTAAATTACAGTCATATTTGGCAGAAAGACCAGCCCTACAAAGTTCCTTTAAACTCACAGAT
AAAAAATCTTTCAAAACTATTACCCCAATATCTGGAAATATACATTATAGTGGAAAAAGCTTTGTATGATTATATGGGATCTGAAATGAT
GGCTGTAACACAAAAAATTGTCCAGGTTATTGGGCTTGTCAACACTATGTTTACCCAGTTCAAATTGACTGTTATACTGTCTTCCTTGGA
ATTGTGGTCAAATGAAAACCAGATTTCCACCAGTGGGGATGCTGATGATATATTACAAAGATTTTTGGCATGGAAACGGGACTATCTCAT
CCTACGGCCCCATGACATAGCATACTTACTTGTTTACAGGAAACATCCTAAATATGTGGGAGCAACATTTCCTGGCACTGTATGCAATAA
AAGCTATGATGCAGGTATTGCTATGTATCCAGATGCAATAGGTTTGGAGGGATTTTCGGTTATTATAGCTCAACTGCTTGGCCTTAATGT
AGGATTAACATATGATGACATCACTCAGTGTTTCTGTCTGAGAGCTACATGCATCATGAATCATGAAGCAGTGAGTGCCAGTGGTAGAAA
GATTTTTAGCAACTGCAGCATGCACGACTATAGATATTTTGTTTCAAAATTTGAGACTAAATGCCTTCAGAAGCTTTCAAATTTGCAACC
ATTACATCAAAATCAACCAGTGTGTGGTAATGGGATTTTGGAATCCAATGAAGAATGTGACTGTGGTAATAAAAATGAATGTCAATTTAA
GAAGTGCTGTGATTATAACACATGTAAACTGAAGGGCTCAGTAAAATGTGGTTCTGGACCATGTTGTACATCAAAGTGTGAGTTGTCAAT
AGCAGGCACTCCATGTAGAAAGAGTATTGATCCAGAGTGTGATTTTACAGAGTACTGCAATGGAACCTCTAGTAATTGTGTTCCTGACAC
TTATGCATTGAATGGCCGTTTGTGCAAGTTGGGAACTGCCTATTGCTATAACGGACAATGTCAAACTACTGATAACCAGTGTGCCAAGAT
ATTTGGAAAAGGTGCTCAAGGTGCTCCATTTGCCTGTTTTAAAGAAGTTAATTCTCTGCATGAAAGATCTGAAAACTGTGGTTTTAAAAA
TTCACAACCATTACCTTGTGAACGGAAGGATGTTCTCTGTGGAAAATTAGCTTGTGTTCAGCCACATAAAAATGCTAATAAAAGTGACGC
TCAATCTACAGTTTATTCATATATTCAAGACCATGTATGTGTATCTATAGCCACTGGTTCCTCCATGAGATCAGATGGAACAGACAATGC
CTATGTGGCTGATGGCACCATGTGTGGTCCAGAAATGTACTGTGTAAATAAAACCTGCAGAAAAGTTCATTTAATGGGATATAACTGTAA
TGCCACCACAAAATGCAAAGGGAAAGGGATATGTAATAATTTTGGTAATTGTCAATGCTTCCCTGGACATAGACCTCCAGATTGTAAATT
CCAGTTTGGTTCCCCAGGGGGTAGTATTGATGATGGAAATTTTCAGAAATCTGGTGACTTTTATACTGAAAAAGGCTACAATACACACTG
GAACAACTGGTTTATTCTGAGTTTCTGCATTTTTCTGCCGTTTTTCATAGTTTTCACCACTGTGATCTTTAAAAGAAATGAAATAAGTAA
ATCATGTAACAGAGAGAATGCAGAGTATAATCGTAATTCATCCGTTGTATCAGAAAGCGATGACGTGGGACATTAATATTGCACAGAACT
TCCATAGCAAATAACCTAAAGGAACGAATGTGCTTTATTTATAACCTTACGTTATCCCCAATGCATTGTAAATGTCAAACTTTTGGAAAA

>In-frame_FGFR1_ENST00000397103_chr8_38314874_-_ADAM18_ENST00000379866_chr8_39463826_+_2288nt
GTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCT
GTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGATTTACATCATTACAATTGATGGACAACC
TTACACTCTACATCTCGGAAAACAATCATTCTTACCCCAGAACTTTTTGGTTTATACATATAATGAAACTGGATCTTTGCATTCTGTGTC
TCCATATTTTATGATGCATTGCCATTACCAAGGATATGCTGCCGAATTTCCAAATTCATTTGTGACACTCAGTATATGTTCTGGTCTCAG
GGGATTTCTCCAGTTTGAAAATATCAGTTATGGAATTGAACCAGTAGAATCTTCAGCAAGATTTGAGCATATAATTTATCAAATGAAAAA
TAATGATCCAAATGTATCCATTTTAGCAGTAAATTACAGTCATATTTGGCAGAAAGACCAGCCCTACAAAGTTCCTTTAAACTCACAGAT
AAAAAATCTTTCAAAACTATTACCCCAATATCTGGAAATATACATTATAGTGGAAAAAGCTTTGATGTTTACCCAGTTCAAATTGACTGT
TATACTGTCTTCCTTGGAATTGTGGTCAAATGAAAACCAGATTTCCACCAGTGGGGATGCTGATGATATATTACAAAGATTTTTGGCATG
GAAACGGGACTATCTCATCCTACGGCCCCATGACATAGCATACTTACTTGTTTACAGGAAACATCCTAAATATGTGGGAGCAACATTTCC
TGGCACTGTATGCAATAAAAGCTATGATGCAGGTATTGCTATGTATCCAGATGCAATAGGTTTGGAGGGATTTTCGGTTATTATAGCTCA
ACTGCTTGGCCTTAATGTAGGATTAACATATGATGACATCACTCAGTGTTTCTGTCTGAGAGCTACATGCATCATGAATCATGAAGCAGT
GAGTGCCAGTGGTAGAAAGATTTTTAGCAACTGCAGCATGCACGACTATAGATATTTTGTTTCAAAATTTGAGACTAAATGCCTTCAGAA
GCTTTCAAATTTGCAACCATTACATCAAAATCAACCAGTGTGTGGTAATGGGATTTTGGAATCCAATGAAGAATGTGACTGTGGTAATAA
AAATGAATGTCAATTTAAGAAGTGCTGTGATTATAACACATGTAAACTGAAGGGCTCAGTAAAATGTGGTTCTGGACCATGTTGTACATC
AAAGTGTGAGTTGTCAATAGCAGGCACTCCATGTAGAAAGAGTATTGATCCAGAGTGTGATTTTACAGAGTACTGCAATGGAACCTCTAG
TAATTGTGTTCCTGACACTTATGCATTGAATGGCCGTTTGTGCAAGTTGGGAACTGCCTATTGCTATAACGGACAATGTCAAACTACTGA
TAACCAGTGTGCCAAGATATTTGGAAAAGGTGCTCAAGGTGCTCCATTTGCCTGTTTTAAAGAAGTTAATTCTCTGCATGAAAGATCTGA
AAACTGTGGTTTTAAAAATTCACAACCATTACCTTGTGAACGGAAGGATGTTCTCTGTGGAAAATTAGCTTGTGTTCAGCCACATAAAAA
TGCTAATAAAAGTGACGCTCAATCTACAGTTTATTCATATATTCAAGACCATGTATGTGTATCTATAGCCACTGGTTCCTCCATGAGATC
AGATGGAACAGACAATGCCTATGTGGCTGATGGCACCATGTGTGGTCCAGAAATGTACTGTGTAAATAAAACCTGCAGAAAAGTTCATTT
AATGGGATATAACTGTAATGCCACCACAAAATGCAAAGGGAAAGGGATATGTAATAATTTTGGTAATTGTCAATGCTTCCCTGGACATAG
ACCTCCAGATTGTAAATTCCAGTTTGGTTCCCCAGGGGGTAGTATTGATGATGGAAATTTTCAGAAATCTGGTGACTTTTATACTGAAAA
AGGCTACAATACACACTGGAACAACTGGTTTATTCTGAGTTTCTGCATTTTTCTGCCGTTTTTCATAGTTTTCACCACTGTGATCTTTAA
AAGAAATGAAATAAGTAAATCATGTAACAGAGAGAATGCAGAGTATAATCGTAATTCATCCGTTGTATCAGAAAGCGATGACGTGGGACA
TTAATATTGCACAGAACTTCCATAGCAAATAACCTAAAGGAACGAATGTGCTTTATTTATAACCTTACGTTATCCCCAATGCATTGTAAA

>In-frame_FGFR1_ENST00000397103_chr8_38314874_-_ADAM18_ENST00000520772_chr8_39463826_+_1407nt
GTGGAGTATCCATGGAGATGTGGAGCCTTGTCACCAACCTCTAACTGCAGAACTGGGATGTGGAGCTGGAAGTGCCTCCTCTTCTGGGCT
GTGCTGGTCACAGCCACACTCTGCACCGCTAGGCCGTCCCCGACCTTGCCTGAACAAGATGATTTACATCATTACAATTGATGGACAACC
TTACACTCTACATCTCGGAAAACAATCATTCTTACCCCAGAACTTTTTGGTTTATACATATAATGAAACTGGATCTTTGCATTCTGTGTC
TCCATATTTTATGATGCATTGCCATTACCAAGGATATGCTGCCGAATTTCCAAATTCATTTGTGACACTCAGTATATGTTCTGGTCTCAG
GGGATTTCTCCAGTTTGAAAATATCAGTTATGGAATTGAACCAGTAGAATCTTCAGCAAGATTTGAGCATATAATTTATCAAATGAAAAA
TAATGATCCAAATGTATCCATTTTAGCAGTAAATTACAGTCATATTTGGCAGAAAGACCAGCCCTACAAAGTTCCTTTAAACTCACAGGT
GACTGTCATCATTCTGATGTTATGACATACTAGAACATTGCCTGTGTAGTTTTCTTGTAAATCATGAAAGGAATTTAGTTAGCTGTTGAG
TAGGAATATTAAATTTTATGTATTTTTCTACCTTTAAATAAAACATTGAAACTTCATCTAAAATATTTGGAAAGTTACATATTTCAAGCT
TAATATTTTATGATGTATTATGTAACATTAATTTTTATATTTTTTTCAAACAAAATGATACTATTGAAAAAGTTTAGAAATGCAGAAAGA
ACAGAGTCACTGTTATTCTAGTACCTTGGTAAAATTACTTTTAATATTTTGTTATATATCTTACATACTACCTGAACATATCTTTCTAAA
ATGCACAGCCATTTGCATGTTGCCAGATGCTCTTAATTTGCTGGTAGACTAGGTATAGAATTCTTGCTGGCAGTTTCTTTCTTTCAGCAC
TTTGAATATTTCAATCCATCACCATGTGGCCTCTGTTTTTTCTGATAAAAATATTCTATTATTCTTATTGGGAATTCCTTGGACAAAATG
AGTTGCTTCTCTTTTGTTTCTTTTGAGATTCTTCCTTTGCCTTTGTCTTATGGCAGTGTGCTTATCATGTTTCTATGAATGGATCTCTTT
GTGTTTACCATACTTGGAGCTCAAAGCACTTCTTGGGTCTGTAAATGGATGTGTTTTGAAATTAAATTAGCTTGTGTGAATCCTGAAAAA
AAAAATCCCATGAAGCTATGAAACCAACTATCTGTATGGTTCCTAGAGACTTCACACTTTTATTCTACTTTAAAATTTGTCTCGATTTTG


Top

FusionGenePPI for FGFR1_ADAM18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGFR1FDPS, FRS3, NCAM1, FGF1, FGFR1, FRS2, PLCG1, FGF2, SHB, GRB14, BNIP2, KPNB1, CREBBP, STAT3, JAK2, SRC, NEDD4, PPP2R1B, FGF23, PTK6, ITK, NCK1, VAV1, HSP90AA1, ERBB3, CTPS2, CDK9, RPS6KA3, CDC20, TSPAN3, CEACAM21, IL20RB, LGALS8, TGFBR2, GINM1, DLK1, LTBR, TNFRSF10B, EVI2A, MREG, HEPACAM2, GOLGA7B, LDLRAD4, CRK, CTNNB1, CDH1, FGF8, SOS1, PIK3R1, PKM, FGF3, FGF5, FGF6, FGF9, FGF10, FGF17, CD44, RPS6KA1, SLA, PIK3R2, SH3BP2, NCK2, TENC1, RTN1, RTN3, PVRL1, EPHA4, YES1, L1CAM, TNK2, AKT1, PDP1, FGFR2, FAM8A1, TMEM30B, LRRN2, LITAF, C16orf58, ZDHHC11, IFNGR1, GAD1, FCGRT, IL27RA, RAET1E, SLC1A1, C14orf37, MANSC1, TPCN2, CD79B, SCN3B, C19orf45, HTR1A, FLRT1, KAL1ADAM18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FGFR1_ADAM18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGFR1P11362DB00039PaliferminFibroblast growth factor receptor 1biotechapproved
HgeneFGFR1P11362DB08896RegorafenibFibroblast growth factor receptor 1small moleculeapproved
HgeneFGFR1P11362DB09079NintedanibFibroblast growth factor receptor 1small moleculeapproved
HgeneFGFR1P11362DB00398SorafenibFibroblast growth factor receptor 1small moleculeapproved|investigational
HgeneFGFR1P11362DB01109HeparinFibroblast growth factor receptor 1small moleculeapproved|investigational
HgeneFGFR1P11362DB08901PonatinibFibroblast growth factor receptor 1small moleculeapproved|investigational
HgeneFGFR1P11362DB09078LenvatinibFibroblast growth factor receptor 1small moleculeapproved|investigational

Top

RelatedDiseases for FGFR1_ADAM18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR1C1563720Kallmann Syndrome 2 (disorder)14ORPHANET;UNIPROT
HgeneFGFR1C0011570Mental Depression5PSYGENET
HgeneFGFR1C0011581Depressive disorder5CTD_human;HPO;PSYGENET
HgeneFGFR1C0005586Bipolar Disorder3PSYGENET
HgeneFGFR1C0041696Unipolar Depression3PSYGENET
HgeneFGFR1C1269683Major Depressive Disorder3PSYGENET
HgeneFGFR1C0027022Myeloproliferative disease2CTD_human
HgeneFGFR1C0220658Pfeiffer Syndrome2UNIPROT
HgeneFGFR1C0406612Encephalocraniocutaneous lipomatosis2ORPHANET;UNIPROT
HgeneFGFR1C0432283Osteoglophonic dwarfism2CTD_human;ORPHANET;UNIPROT
HgeneFGFR1C1458155Mammary Neoplasms2CTD_human
HgeneFGFR1C1845146Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate2ORPHANET;UNIPROT
HgeneFGFR1C0004114Astrocytoma1CTD_human
HgeneFGFR1C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneFGFR1C0007137Squamous cell carcinoma1CTD_human
HgeneFGFR1C0008924Cleft Lip1CTD_human;HPO
HgeneFGFR1C0008925Cleft Palate1CTD_human;HPO
HgeneFGFR1C0017638Glioma1CTD_human
HgeneFGFR1C0024121Lung Neoplasms1CTD_human
HgeneFGFR1C0036341Schizophrenia1CTD_human
HgeneFGFR1C0149925Small cell carcinoma of lung1CTD_human
HgeneFGFR1C0376634Craniofacial Abnormalities1CTD_human
HgeneFGFR1C0432122Interfrontal craniofaciosynostosis1CTD_human;UNIPROT