FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13377

FusionGeneSummary for FGF1_C16orf62

check button Fusion gene summary
Fusion gene informationFusion gene name: FGF1_C16orf62
Fusion gene ID: 13377
HgeneTgene
Gene symbol

FGF1

C16orf62

Gene ID

2246

Gene namefibroblast growth factor 1
SynonymsAFGF|ECGF|ECGF-beta|ECGFA|ECGFB|FGF-1|FGF-alpha|FGFA|GLIO703|HBGF-1|HBGF1
Cytomap

5q31.3

Type of geneprotein-coding
Descriptionfibroblast growth factor 1beta-endothelial cell growth factorendothelial cell growth factor, alphaendothelial cell growth factor, betafibroblast growth factor 1 (acidic)heparin-binding growth factor 1
Modification date20180522
UniProtAcc

P05230

Q7Z3J2

Ensembl transtripts involved in fusion geneENST00000359370, ENST00000378046, 
ENST00000337706, ENST00000360966, 
ENST00000407758, ENST00000419524, 
ENST00000494579, 
ENST00000438132, 
ENST00000542263, ENST00000417362, 
ENST00000251143, ENST00000543152, 
ENST00000448695, ENST00000544275, 
ENST00000538853, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 8 X 7=560
# samples 114
** MAII scorelog2(1/1*10)=3.32192809488736log2(14/560*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGF1 [Title/Abstract] AND C16orf62 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGF1

GO:0008543

fibroblast growth factor receptor signaling pathway

20145243

HgeneFGF1

GO:0030335

positive regulation of cell migration

20145243

HgeneFGF1

GO:0034605

cellular response to heat

12746488

HgeneFGF1

GO:0043406

positive regulation of MAP kinase activity

16756958

HgeneFGF1

GO:0045542

positive regulation of cholesterol biosynthetic process

19229075

HgeneFGF1

GO:0045766

positive regulation of angiogenesis

20145243

HgeneFGF1

GO:0045944

positive regulation of transcription by RNA polymerase II

19229075

HgeneFGF1

GO:0051781

positive regulation of cell division

20145243

HgeneFGF1

GO:0060681

branch elongation involved in ureteric bud branching

11731227

HgeneFGF1

GO:0072163

mesonephric epithelium development

11731227

HgeneFGF1

GO:1902533

positive regulation of intracellular signal transduction

19229075

HgeneFGF1

GO:2000544

regulation of endothelial cell chemotaxis to fibroblast growth factor

16756958


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA205510FGF1chr5

141980340

-C16orf62chr16

19641112

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000359370ENST00000438132FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000359370ENST00000542263FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000359370ENST00000417362FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000359370ENST00000251143FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000359370ENST00000543152FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000359370ENST00000448695FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000359370ENST00000544275FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000359370ENST00000538853FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000378046ENST00000438132FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000378046ENST00000542263FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000378046ENST00000417362FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000378046ENST00000251143FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000378046ENST00000543152FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000378046ENST00000448695FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000378046ENST00000544275FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000378046ENST00000538853FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000337706ENST00000438132FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000337706ENST00000542263FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000337706ENST00000417362FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000337706ENST00000251143FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000337706ENST00000543152FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000337706ENST00000448695FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000337706ENST00000544275FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000337706ENST00000538853FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000360966ENST00000438132FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000360966ENST00000542263FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000360966ENST00000417362FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000360966ENST00000251143FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000360966ENST00000543152FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000360966ENST00000448695FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000360966ENST00000544275FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000360966ENST00000538853FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000407758ENST00000438132FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000407758ENST00000542263FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000407758ENST00000417362FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000407758ENST00000251143FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000407758ENST00000543152FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000407758ENST00000448695FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000407758ENST00000544275FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000407758ENST00000538853FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000419524ENST00000438132FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000419524ENST00000542263FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000419524ENST00000417362FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000419524ENST00000251143FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000419524ENST00000543152FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000419524ENST00000448695FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000419524ENST00000544275FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000419524ENST00000538853FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000494579ENST00000438132FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000494579ENST00000542263FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000494579ENST00000417362FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000494579ENST00000251143FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000494579ENST00000543152FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-3CDSENST00000494579ENST00000448695FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000494579ENST00000544275FGF1chr5

141980340

-C16orf62chr16

19641112

+
intron-intronENST00000494579ENST00000538853FGF1chr5

141980340

-C16orf62chr16

19641112

+

Top

FusionProtFeatures for FGF1_C16orf62


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGF1

P05230

C16orf62

Q7Z3J2

Plays an important role in the regulation of cellsurvival, cell division, angiogenesis, cell differentiation andcell migration. Functions as potent mitogen in vitro. Acts as aligand for FGFR1 and integrins. Binds to FGFR1 in the presence ofheparin leading to FGFR1 dimerization and activation viasequential autophosphorylation on tyrosine residues which act asdocking sites for interacting proteins, leading to the activationof several signaling cascades. Binds to integrin ITGAV:ITGB3. Itsbinding to integrin, subsequent ternary complex formation withintegrin and FGFR1, and the recruitment of PTPN11 to the complexare essential for FGF1 signaling. Induces the phosphorylation andactivation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1(PubMed:18441324, PubMed:20422052). Can induce angiogenesis(PubMed:23469107). {ECO:0000269|PubMed:16597617,ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:20145243,ECO:0000269|PubMed:20422052, ECO:0000269|PubMed:23469107,ECO:0000269|PubMed:8663044}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FGF1_C16orf62


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FGF1_C16orf62


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FGF1_C16orf62


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFGF1P05230DB00686Pentosan PolysulfateFibroblast growth factor 1small moleculeapproved
HgeneFGF1P05230DB06589PazopanibFibroblast growth factor 1small moleculeapproved
HgeneFGF1P05230DB01025AmlexanoxFibroblast growth factor 1small moleculeapproved|investigational
HgeneFGF1P05230DB01109HeparinFibroblast growth factor 1small moleculeapproved|investigational

Top

RelatedDiseases for FGF1_C16orf62


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGF1C0020649Hypotension1CTD_human
HgeneFGF1C0023418leukemia1CTD_human
HgeneFGF1C0025500Mesothelioma1CTD_human
HgeneFGF1C0034069Pulmonary Fibrosis1CTD_human
HgeneFGF1C0043094Weight Gain1CTD_human
HgeneFGF1C0151744Myocardial Ischemia1CTD_human
HgeneFGF1C0919267ovarian neoplasm1CTD_human