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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13374

FusionGeneSummary for FGF13_DYM

check button Fusion gene summary
Fusion gene informationFusion gene name: FGF13_DYM
Fusion gene ID: 13374
HgeneTgene
Gene symbol

FGF13

DYM

Gene ID

2258

54808

Gene namefibroblast growth factor 13dymeclin
SynonymsFGF-13|FGF2|FHF-2|FHF2DMC|SMC
Cytomap

Xq26.3-q27.1

18q21.1

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor 13fibroblast growth factor homologous factor 2dymeclindyggve-Melchior-Clausen syndrome protein
Modification date2018051920180523
UniProtAcc

Q92913

Q7RTS9

Ensembl transtripts involved in fusion geneENST00000315930, ENST00000305414, 
ENST00000441825, ENST00000370603, 
ENST00000541469, 		ENST00000442713, 
ENST00000269445, ENST00000584977, 
ENST00000578396, 
Fusion gene scores* DoF score6 X 3 X 4=728 X 5 X 8=320
# samples 69
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGF13 [Title/Abstract] AND DYM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGF13

GO:0000165

MAPK cascade

12244047


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-J9-A52E-01AFGF13chrX

137939674

-DYMchr18

46690157

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000315930ENST00000442713FGF13chrX

137939674

-DYMchr18

46690157

-
intron-3CDSENST00000315930ENST00000269445FGF13chrX

137939674

-DYMchr18

46690157

-
intron-intronENST00000315930ENST00000584977FGF13chrX

137939674

-DYMchr18

46690157

-
intron-intronENST00000315930ENST00000578396FGF13chrX

137939674

-DYMchr18

46690157

-
intron-3CDSENST00000305414ENST00000442713FGF13chrX

137939674

-DYMchr18

46690157

-
intron-3CDSENST00000305414ENST00000269445FGF13chrX

137939674

-DYMchr18

46690157

-
intron-intronENST00000305414ENST00000584977FGF13chrX

137939674

-DYMchr18

46690157

-
intron-intronENST00000305414ENST00000578396FGF13chrX

137939674

-DYMchr18

46690157

-
Frame-shiftENST00000441825ENST00000442713FGF13chrX

137939674

-DYMchr18

46690157

-
Frame-shiftENST00000441825ENST00000269445FGF13chrX

137939674

-DYMchr18

46690157

-
5CDS-intronENST00000441825ENST00000584977FGF13chrX

137939674

-DYMchr18

46690157

-
5CDS-intronENST00000441825ENST00000578396FGF13chrX

137939674

-DYMchr18

46690157

-
Frame-shiftENST00000370603ENST00000442713FGF13chrX

137939674

-DYMchr18

46690157

-
Frame-shiftENST00000370603ENST00000269445FGF13chrX

137939674

-DYMchr18

46690157

-
5CDS-intronENST00000370603ENST00000584977FGF13chrX

137939674

-DYMchr18

46690157

-
5CDS-intronENST00000370603ENST00000578396FGF13chrX

137939674

-DYMchr18

46690157

-
intron-3CDSENST00000541469ENST00000442713FGF13chrX

137939674

-DYMchr18

46690157

-
intron-3CDSENST00000541469ENST00000269445FGF13chrX

137939674

-DYMchr18

46690157

-
intron-intronENST00000541469ENST00000584977FGF13chrX

137939674

-DYMchr18

46690157

-
intron-intronENST00000541469ENST00000578396FGF13chrX

137939674

-DYMchr18

46690157

-

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FusionProtFeatures for FGF13_DYM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGF13

Q92913

DYM

Q7RTS9

Microtubule-binding protein which directly binds tubulinand is involved in both polymerization and stabilization ofmicrotubules. Through its action on microtubules, may participateto the refinement of axons by negatively regulating axonal andleading processes branching. Plays a crucial role in neuronpolarization and migration in the cerebral cortex and thehippocampus. {ECO:0000269|PubMed:15282281}. May regulate voltage-gated sodium channels transport andfunction. {ECO:0000269|PubMed:15282281}. May also play a role in MAPK signaling.{ECO:0000269|PubMed:15282281}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGF13_DYM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGF13_DYM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGF13MAPK8IP2, PRNP, PSEN1, APPDYMHS2ST1, VSIG2, PNKD, P2RY12, PTGER3, DUSP28, SIGLECL1, EPHA1, VIPR1, CHRM3, CD70, FPR2, VIPR2, FZD10, TNFSF13B, SLCO1B1, OPRM1, PTPRN


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGF13_DYM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FGF13_DYM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGF13C0027627Neoplasm Metastasis1CTD_human
HgeneFGF13C0030297Pancreatic Neoplasm1CTD_human
TgeneDYMC3888088SMITH-MCCORT DYSPLASIA 13UNIPROT
TgeneDYMC0265286Dyggve-Melchior-Clausen syndrome2CTD_human;ORPHANET;UNIPROT
TgeneDYMC0036341Schizophrenia1PSYGENET