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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13371

FusionGeneSummary for FGF13_CDK14

check button Fusion gene summary
Fusion gene informationFusion gene name: FGF13_CDK14
Fusion gene ID: 13371
HgeneTgene
Gene symbol

FGF13

CDK14

Gene ID

2258

5218

Gene namefibroblast growth factor 13cyclin dependent kinase 14
SynonymsFGF-13|FGF2|FHF-2|FHF2PFTAIRE1|PFTK1
Cytomap

Xq26.3-q27.1

7q21.13

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor 13fibroblast growth factor homologous factor 2cyclin-dependent kinase 14PFTAIRE protein kinase 1cell division protein kinase 14serine/threonine-protein kinase PFTAIRE-1
Modification date2018051920180523
UniProtAcc

Q92913

O94921

Ensembl transtripts involved in fusion geneENST00000315930, ENST00000305414, 
ENST00000441825, ENST00000370603, 
ENST00000541469, 		ENST00000380050, 
ENST00000265741, ENST00000406263, 
ENST00000436577, ENST00000496279, 
Fusion gene scores* DoF score6 X 3 X 4=7217 X 14 X 9=2142
# samples 619
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2142*10)=-3.49488715641931
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGF13 [Title/Abstract] AND CDK14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGF13

GO:0000165

MAPK cascade

12244047

TgeneCDK14

GO:0000086

G2/M transition of mitotic cell cycle

20059949

TgeneCDK14

GO:0060828

regulation of canonical Wnt signaling pathway

20059949


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1D16473FGF13chrX

137823303

-CDK14chr7

90681025

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000315930ENST00000380050FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000315930ENST00000265741FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000315930ENST00000406263FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000315930ENST00000436577FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000315930ENST00000496279FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000305414ENST00000380050FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000305414ENST00000265741FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000305414ENST00000406263FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000305414ENST00000436577FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000305414ENST00000496279FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000441825ENST00000380050FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000441825ENST00000265741FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000441825ENST00000406263FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000441825ENST00000436577FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000441825ENST00000496279FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000370603ENST00000380050FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000370603ENST00000265741FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000370603ENST00000406263FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000370603ENST00000436577FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000370603ENST00000496279FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000541469ENST00000380050FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000541469ENST00000265741FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000541469ENST00000406263FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000541469ENST00000436577FGF13chrX

137823303

-CDK14chr7

90681025

+
intron-intronENST00000541469ENST00000496279FGF13chrX

137823303

-CDK14chr7

90681025

+

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FusionProtFeatures for FGF13_CDK14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGF13

Q92913

CDK14

O94921

Microtubule-binding protein which directly binds tubulinand is involved in both polymerization and stabilization ofmicrotubules. Through its action on microtubules, may participateto the refinement of axons by negatively regulating axonal andleading processes branching. Plays a crucial role in neuronpolarization and migration in the cerebral cortex and thehippocampus. {ECO:0000269|PubMed:15282281}. May regulate voltage-gated sodium channels transport andfunction. {ECO:0000269|PubMed:15282281}. May also play a role in MAPK signaling.{ECO:0000269|PubMed:15282281}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGF13_CDK14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGF13_CDK14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGF13_CDK14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FGF13_CDK14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGF13C0027627Neoplasm Metastasis1CTD_human
HgeneFGF13C0030297Pancreatic Neoplasm1CTD_human
TgeneCDK14C2239176Liver carcinoma1CTD_human