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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13368

FusionGeneSummary for FGF12_SENP6

check button Fusion gene summary
Fusion gene informationFusion gene name: FGF12_SENP6
Fusion gene ID: 13368
HgeneTgene
Gene symbol

FGF12

SENP6

Gene ID

2257

26054

Gene namefibroblast growth factor 12SUMO specific peptidase 6
SynonymsEIEE47|FGF12B|FHF1SSP1|SUSP1
Cytomap

3q28-q29

6q14.1

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor 12fibroblast growth factor 12Bfibroblast growth factor FGF-12bfibroblast growth factor homologous factor 1myocyte-activating factorsentrin-specific protease 62810017C20RikSUMO-1-specific protease 1SUMO1/sentrin specific peptidase 6SUMO1/sentrin specific protease 6sentrin/SUMO-specific protease SENP6
Modification date2018051920180523
UniProtAcc

P61328

Q9GZR1

Ensembl transtripts involved in fusion geneENST00000445105, ENST00000264730, 
ENST00000454309, ENST00000450716, 
ENST00000430714, ENST00000466144, 
ENST00000370010, ENST00000370014, 
ENST00000447266, ENST00000541192, 
ENST00000327284, ENST00000436928, 
Fusion gene scores* DoF score6 X 3 X 4=728 X 12 X 6=576
# samples 714
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/576*10)=-2.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGF12 [Title/Abstract] AND SENP6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSENP6

GO:0070646

protein modification by small protein removal

20212317


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA678812FGF12chr3

192120891

+SENP6chr6

76425446

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000445105ENST00000370010FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000445105ENST00000370014FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000445105ENST00000447266FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000445105ENST00000541192FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000445105ENST00000327284FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000445105ENST00000436928FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000264730ENST00000370010FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000264730ENST00000370014FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000264730ENST00000447266FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000264730ENST00000541192FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000264730ENST00000327284FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000264730ENST00000436928FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000454309ENST00000370010FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000454309ENST00000370014FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000454309ENST00000447266FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000454309ENST00000541192FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000454309ENST00000327284FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000454309ENST00000436928FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000450716ENST00000370010FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000450716ENST00000370014FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000450716ENST00000447266FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000450716ENST00000541192FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000450716ENST00000327284FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000450716ENST00000436928FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000430714ENST00000370010FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000430714ENST00000370014FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000430714ENST00000447266FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000430714ENST00000541192FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000430714ENST00000327284FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000430714ENST00000436928FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000466144ENST00000370010FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000466144ENST00000370014FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000466144ENST00000447266FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-3UTRENST00000466144ENST00000541192FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000466144ENST00000327284FGF12chr3

192120891

+SENP6chr6

76425446

+
intron-intronENST00000466144ENST00000436928FGF12chr3

192120891

+SENP6chr6

76425446

+

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FusionProtFeatures for FGF12_SENP6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGF12

P61328

SENP6

Q9GZR1

Involved in nervous system development and function.Involved in the positive regulation of voltage-gated sodiumchannel activity. Promotes neuronal excitability by elevating thevoltage dependence of neuronal sodium channel SCN8A fastinactivation. {ECO:0000269|PubMed:27164707}. Protease that deconjugates SUMO1, SUMO2 and SUMO3 fromtargeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 andSUMO3 precursors. Deconjugates SUMO1 from RXRA, leading totranscriptional activation. Involved in chromosome alignment andspindle assembly, by regulating the kinetochore CENPH-CENPI-CENPKcomplex. Desumoylates PML and CENPI, protecting them fromdegradation by the ubiquitin ligase RNF4, which targetspolysumoylated proteins for proteasomal degradation. Desumoylatesalso RPA1, thus preventing recruitment of RAD51 to the DNA damagefoci to initiate DNA repair through homologous recombination.{ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875,ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317,ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGF12_SENP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGF12_SENP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGF12_SENP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FGF12_SENP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource