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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13360

FusionGeneSummary for FGD6_PTPRR

check button Fusion gene summary
Fusion gene informationFusion gene name: FGD6_PTPRR
Fusion gene ID: 13360
HgeneTgene
Gene symbol

FGD6

PTPRR

Gene ID

55785

5801

Gene nameFYVE, RhoGEF and PH domain containing 6protein tyrosine phosphatase, receptor type R
SynonymsZFYVE24EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ
Cytomap

12q22

12q15

Type of geneprotein-codingprotein-coding
DescriptionFYVE, RhoGEF and PH domain-containing protein 6zinc finger FYVE domain-containing protein 24receptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1
Modification date2018051920180519
UniProtAcc

Q6ZV73

Q15256

Ensembl transtripts involved in fusion geneENST00000343958, ENST00000546711, 
ENST00000549499, ENST00000550368, 
ENST00000283228, ENST00000440835, 
ENST00000537619, ENST00000378778, 
ENST00000342084, ENST00000549308, 
Fusion gene scores* DoF score6 X 5 X 4=12033 X 13 X 10=4290
# samples 731
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(31/4290*10)=-3.79063752711267
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FGD6 [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-AB37-01AFGD6chr12

95483345

-PTPRRchr12

71033057

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000343958ENST00000283228FGD6chr12

95483345

-PTPRRchr12

71033057

-
Frame-shitENST00000343958ENST00000440835FGD6chr12

95483345

-PTPRRchr12

71033057

-
5CDS-5UTRENST00000343958ENST00000537619FGD6chr12

95483345

-PTPRRchr12

71033057

-
5CDS-5UTRENST00000343958ENST00000378778FGD6chr12

95483345

-PTPRRchr12

71033057

-
5CDS-5UTRENST00000343958ENST00000342084FGD6chr12

95483345

-PTPRRchr12

71033057

-
5CDS-5UTRENST00000343958ENST00000549308FGD6chr12

95483345

-PTPRRchr12

71033057

-
Frame-shitENST00000546711ENST00000283228FGD6chr12

95483345

-PTPRRchr12

71033057

-
Frame-shitENST00000546711ENST00000440835FGD6chr12

95483345

-PTPRRchr12

71033057

-
5CDS-5UTRENST00000546711ENST00000537619FGD6chr12

95483345

-PTPRRchr12

71033057

-
5CDS-5UTRENST00000546711ENST00000378778FGD6chr12

95483345

-PTPRRchr12

71033057

-
5CDS-5UTRENST00000546711ENST00000342084FGD6chr12

95483345

-PTPRRchr12

71033057

-
5CDS-5UTRENST00000546711ENST00000549308FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-3CDSENST00000549499ENST00000283228FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-3CDSENST00000549499ENST00000440835FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-5UTRENST00000549499ENST00000537619FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-5UTRENST00000549499ENST00000378778FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-5UTRENST00000549499ENST00000342084FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-5UTRENST00000549499ENST00000549308FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-3CDSENST00000550368ENST00000283228FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-3CDSENST00000550368ENST00000440835FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-5UTRENST00000550368ENST00000537619FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-5UTRENST00000550368ENST00000378778FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-5UTRENST00000550368ENST00000342084FGD6chr12

95483345

-PTPRRchr12

71033057

-
intron-5UTRENST00000550368ENST00000549308FGD6chr12

95483345

-PTPRRchr12

71033057

-

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FusionProtFeatures for FGD6_PTPRR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGD6

Q6ZV73

PTPRR

Q15256

May activate CDC42, a member of the Ras-like family ofRho- and Rac proteins, by exchanging bound GDP for free GTP. Mayplay a role in regulating the actin cytoskeleton and cell shape(By similarity). {ECO:0000250}. Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FGD6_PTPRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FGD6_PTPRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FGD6GRB2, NPM1, DBNL, GBA, PDGFRB, CTR9, PLK2, CCDC102B, KCTD3, KIF13B, CGN, ZBTB21, KSR1, CBY1, TRIM25PTPRRMAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FGD6_PTPRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FGD6_PTPRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGD6C0345967Malignant mesothelioma1CTD_human
HgeneFGD6C2237660exudative macular degeneration1CTD_human
TgenePTPRRC0041696Unipolar Depression1PSYGENET
TgenePTPRRC1269683Major Depressive Disorder1PSYGENET