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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1336

FusionGeneSummary for AKAP2_AGTPBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP2_AGTPBP1
Fusion gene ID: 1336
HgeneTgene
Gene symbol

AKAP2

AGTPBP1

Gene ID

445815

23287

Gene namePALM2-AKAP2 readthroughATP/GTP binding protein 1
SynonymsAKAP2CCP1|NNA1
Cytomap

9q31.3

9q21.33

Type of geneprotein-codingprotein-coding
DescriptionPALM2-AKAP2 proteinPALM2-AKAP2 readthrough transcriptcytosolic carboxypeptidase 1carboxypeptidase-tubulinnervous system nuclear protein induced by axotomy protein 1 homologsoluble carboxypeptidasetubulinyl-Tyr carboxypeptidasetyrosine carboxypeptidase
Modification date2018051920180519
UniProtAcc

Q9Y2D5

Q9UPW5

Ensembl transtripts involved in fusion geneENST00000510514, ENST00000555236, 
ENST00000434623, ENST00000374525, 
ENST00000259318, ENST00000482335, 
ENST00000337006, ENST00000376083, 
ENST00000357081, ENST00000376109, 
ENST00000432218, ENST00000376081, 
ENST00000491784, ENST00000376080, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 3 X 4=48
# samples 44
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP2 [Title/Abstract] AND AGTPBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-K1-A6RU-01AAKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000510514ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000510514ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000510514ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000510514ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000510514ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000510514ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000510514ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000510514ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000555236ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000555236ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000555236ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000555236ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000555236ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000555236ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000555236ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000555236ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000434623ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000434623ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000434623ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000434623ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000434623ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000434623ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000434623ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000434623ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000374525ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000374525ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000374525ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000374525ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000374525ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-5UTRENST00000374525ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000374525ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
5CDS-intronENST00000374525ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000259318ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000259318ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000259318ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000259318ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000259318ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000259318ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000259318ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000259318ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000482335ENST00000337006AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000482335ENST00000376083AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000482335ENST00000357081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000482335ENST00000376109AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000482335ENST00000432218AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-5UTRENST00000482335ENST00000376081AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000482335ENST00000491784AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-
intron-intronENST00000482335ENST00000376080AKAP2chr9

112811135

+AGTPBP1chr9

88327481

-

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FusionProtFeatures for AKAP2_AGTPBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP2

Q9Y2D5

AGTPBP1

Q9UPW5

Binds to regulatory subunit (RII) of protein kinase A.May be involved in establishing polarity in signaling systems orin integrating PKA-RII isoforms with downstream effectors tocapture, amplify and focus diffuse, trans-cellular signals carriedby cAMP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AKAP2_AGTPBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AKAP2_AGTPBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AKAP2PRKAR2A, BABAM1, BRE, CSTF2, KIAA0196, KIF5B, PIH1D1, RPP38, SART3, CCDC8, LUZP4, PRKAR2B, BTRC, CAPZA2, DBN1, FLNA, MYH9, PPP1CB, IQGAP1, PDLIM7, SYNPO, LIMA1, ANLN, MYO5C, MYO18A, CDH1, PDHA1, TESAGTPBP1DISC1, TNIK, CYCS, NYNRIN, CBY1, PPFIA1, PPFIA4, ENO1, PNKP, TMOD1, CEP128, XPO1, FOXK1, EGFR, PHLPP1, TTLL4, UBC, FBXL13


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AKAP2_AGTPBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AKAP2_AGTPBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP2C0043094Weight Gain1CTD_human
TgeneAGTPBP1C0027746Nerve Degeneration1CTD_human