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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13324

FusionGeneSummary for FEZ2_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: FEZ2_MBP
Fusion gene ID: 13324
HgeneTgene
Gene symbol

FEZ2

MBP

Gene ID

9637

5553

Gene namefasciculation and elongation protein zeta 2proteoglycan 2, pro eosinophil major basic protein
SynonymsHUM3CLBMPG|MBP|MBP1|proMBP
Cytomap

2p22.2

11q12.1

Type of geneprotein-codingprotein-coding
Descriptionfasciculation and elongation protein zeta-2pre-T/NK cell associated protein (3Cl)zygin 2zygin IIbone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018052320180519
UniProtAcc

Q9UHY8

P02686

Ensembl transtripts involved in fusion geneENST00000379245, ENST00000305852, 
ENST00000405912, ENST00000487919, 
ENST00000382582, ENST00000355994, 
ENST00000397875, ENST00000397866, 
ENST00000397865, ENST00000527041, 
ENST00000359645, ENST00000528160, 
ENST00000397869, ENST00000354542, 
ENST00000526111, ENST00000580402, 
ENST00000579129, ENST00000578193, 
ENST00000397863, ENST00000397860, 
ENST00000487778, 
Fusion gene scores* DoF score3 X 3 X 2=1826 X 20 X 3=1560
# samples 327
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FEZ2 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA132184FEZ2chr2

36789467

-MBPchr18

74729011

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000379245ENST00000382582FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000355994FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000397875FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000397866FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000397865FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000527041FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-intronENST00000379245ENST00000359645FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000528160FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000397869FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000354542FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000526111FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000580402FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000579129FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000578193FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000397863FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000397860FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000379245ENST00000487778FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000382582FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000355994FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000397875FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000397866FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000397865FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000527041FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-intronENST00000305852ENST00000359645FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000528160FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000397869FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000354542FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000526111FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000580402FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000579129FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000578193FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000397863FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000397860FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000305852ENST00000487778FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000382582FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000355994FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000397875FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000397866FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000397865FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000527041FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-intronENST00000405912ENST00000359645FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000528160FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000397869FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000354542FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000526111FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000580402FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000579129FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000578193FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000397863FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000397860FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000405912ENST00000487778FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000382582FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000355994FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000397875FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000397866FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000397865FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000527041FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-intronENST00000487919ENST00000359645FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000528160FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000397869FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000354542FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000526111FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000580402FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000579129FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000578193FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000397863FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000397860FEZ2chr2

36789467

-MBPchr18

74729011

-
intron-5UTRENST00000487919ENST00000487778FEZ2chr2

36789467

-MBPchr18

74729011

-

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FusionProtFeatures for FEZ2_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FEZ2

Q9UHY8

MBP

P02686

Involved in axonal outgrowth and fasciculation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FEZ2_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FEZ2_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FEZ2_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FEZ2_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFEZ2C0043094Weight Gain1CTD_human
HgeneFEZ2C0151744Myocardial Ischemia1CTD_human
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human