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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13323

FusionGeneSummary for FEZ2_FEZ2

check button Fusion gene summary
Fusion gene informationFusion gene name: FEZ2_FEZ2
Fusion gene ID: 13323
HgeneTgene
Gene symbol

FEZ2

FEZ2

Gene ID

9637

9637

Gene namefasciculation and elongation protein zeta 2fasciculation and elongation protein zeta 2
SynonymsHUM3CLHUM3CL
Cytomap

2p22.2

2p22.2

Type of geneprotein-codingprotein-coding
Descriptionfasciculation and elongation protein zeta-2pre-T/NK cell associated protein (3Cl)zygin 2zygin IIfasciculation and elongation protein zeta-2pre-T/NK cell associated protein (3Cl)zygin 2zygin II
Modification date2018052320180523
UniProtAcc

Q9UHY8

Q9UHY8

Ensembl transtripts involved in fusion geneENST00000379245, ENST00000305852, 
ENST00000405912, ENST00000487919, 
ENST00000379245, ENST00000305852, 
ENST00000405912, ENST00000487919, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: FEZ2 [Title/Abstract] AND FEZ2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE812729FEZ2chr2

36805773

-FEZ2chr2

36780243

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000379245ENST00000379245FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000379245ENST00000305852FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000379245ENST00000405912FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-5UTRENST00000379245ENST00000487919FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000305852ENST00000379245FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000305852ENST00000305852FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000305852ENST00000405912FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-5UTRENST00000305852ENST00000487919FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000405912ENST00000379245FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000405912ENST00000305852FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000405912ENST00000405912FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-5UTRENST00000405912ENST00000487919FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000487919ENST00000379245FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000487919ENST00000305852FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-3UTRENST00000487919ENST00000405912FEZ2chr2

36805773

-FEZ2chr2

36780243

+
intron-5UTRENST00000487919ENST00000487919FEZ2chr2

36805773

-FEZ2chr2

36780243

+

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FusionProtFeatures for FEZ2_FEZ2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FEZ2

Q9UHY8

FEZ2

Q9UHY8

Involved in axonal outgrowth and fasciculation.{ECO:0000250}. Involved in axonal outgrowth and fasciculation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FEZ2_FEZ2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FEZ2_FEZ2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FEZ2_FEZ2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FEZ2_FEZ2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFEZ2C0043094Weight Gain1CTD_human
HgeneFEZ2C0151744Myocardial Ischemia1CTD_human
TgeneFEZ2C0043094Weight Gain1CTD_human
TgeneFEZ2C0151744Myocardial Ischemia1CTD_human