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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1332

FusionGeneSummary for AKAP1_GGA3

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP1_GGA3
Fusion gene ID: 1332
HgeneTgene
Gene symbol

AKAP1

GGA3

Gene ID

8165

23163

Gene nameA-kinase anchoring protein 1golgi associated, gamma adaptin ear containing, ARF binding protein 3
SynonymsAKAP|AKAP121|AKAP149|AKAP84|D-AKAP1|PPP1R43|PRKA1|SAKAP84|TDRD17-
Cytomap

17q22

17q25.1

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 1, mitochondrialA kinase (PRKA) anchor protein 1A-kinase anchor protein 149 kDaAKAP 149D-AKAP-1dual-specificity A-kinase anchoring protein 1protein kinase A anchoring protein 1protein kinase A1protein phosphatase 1, regulatADP-ribosylation factor-binding protein GGA3Golgi-localized, gamma ear-containing, ARF-binding protein 3
Modification date2018051920180522
UniProtAcc

Q92667

Q9NZ52

Ensembl transtripts involved in fusion geneENST00000337714, ENST00000314126, 
ENST00000571629, ENST00000572557, 
ENST00000539273, 		ENST00000351904, 
ENST00000245541, ENST00000578348, 
ENST00000582486, ENST00000538886, 
ENST00000582717, ENST00000537686, 
ENST00000579743, 
Fusion gene scores* DoF score6 X 3 X 2=363 X 1 X 2=6
# samples 53
** MAII scorelog2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/6*10)=2.32192809488736
Context

PubMed: AKAP1 [Title/Abstract] AND GGA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A15H-01AAKAP1chr17

55162759

+GGA3chr17

73242877

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000337714ENST00000351904AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-3CDSENST00000337714ENST00000245541AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-5UTRENST00000337714ENST00000578348AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-5UTRENST00000337714ENST00000582486AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-intronENST00000337714ENST00000538886AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-5UTRENST00000337714ENST00000582717AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-5UTRENST00000337714ENST00000537686AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-5UTRENST00000337714ENST00000579743AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-3CDSENST00000314126ENST00000351904AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-3CDSENST00000314126ENST00000245541AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-5UTRENST00000314126ENST00000578348AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-5UTRENST00000314126ENST00000582486AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-intronENST00000314126ENST00000538886AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-5UTRENST00000314126ENST00000582717AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-5UTRENST00000314126ENST00000537686AKAP1chr17

55162759

+GGA3chr17

73242877

-
5UTR-5UTRENST00000314126ENST00000579743AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-3CDSENST00000571629ENST00000351904AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-3CDSENST00000571629ENST00000245541AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000571629ENST00000578348AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000571629ENST00000582486AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-intronENST00000571629ENST00000538886AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000571629ENST00000582717AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000571629ENST00000537686AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000571629ENST00000579743AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-3CDSENST00000572557ENST00000351904AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-3CDSENST00000572557ENST00000245541AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000572557ENST00000578348AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000572557ENST00000582486AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-intronENST00000572557ENST00000538886AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000572557ENST00000582717AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000572557ENST00000537686AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000572557ENST00000579743AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-3CDSENST00000539273ENST00000351904AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-3CDSENST00000539273ENST00000245541AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000539273ENST00000578348AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000539273ENST00000582486AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-intronENST00000539273ENST00000538886AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000539273ENST00000582717AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000539273ENST00000537686AKAP1chr17

55162759

+GGA3chr17

73242877

-
intron-5UTRENST00000539273ENST00000579743AKAP1chr17

55162759

+GGA3chr17

73242877

-

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FusionProtFeatures for AKAP1_GGA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP1

Q92667

GGA3

Q9NZ52

Binds to type I and II regulatory subunits of proteinkinase A and anchors them to the cytoplasmic face of themitochondrial outer membrane. Plays a role in protein sorting and trafficking betweenthe trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and bindsubiquitinated proteins and membrane cargo molecules with acytosolic acidic cluster-dileucine (AC-LL) motif.{ECO:0000269|PubMed:11301005}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AKAP1_GGA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AKAP1_GGA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AKAP1PRKAR1B, PRKAR1A, AMY1A, PRKAR2A, MAATS1, MYCBP, SIAH2, USP7, TP73, APP, PRKACA, PRKACB, APBB2, PRKAR2B, ZFP41, NTRK1, FGFR1OP, TMEM67, PHB, RPL12, TNNI3, CKAP5, FARP1, PHB2, WIBG, LARP4, NPAS1, PRKACG, PRSS37, RPP25, REEP5GGA3ARF1, TSG101, ARF3, M6PR, CLTC, RABEP1, LAPTM5, NEDD4, VPS18, VPS11, UBC, PACS1, ARF6, IGF2R, SYNRG, CLINT1, BACE1, TBC1D3, STAB1, GGA1, GGA2, SORT1, CDKN2A, MET, CRK, MON2, RNF11, ITCH, MOV10, NXF1, TOLLIP, HAUS4, TMEM17, CDH1, CYTH2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AKAP1_GGA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AKAP1_GGA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP1C0028754Obesity1CTD_human