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Fusion gene ID: 13316 |
FusionGeneSummary for FERMT2_FERMT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FERMT2_FERMT2 | Fusion gene ID: 13316 | Hgene | Tgene | Gene symbol | FERMT2 | FERMT2 | Gene ID | 10979 | 10979 |
| Gene name | fermitin family member 2 | fermitin family member 2 | |
| Synonyms | KIND2|MIG2|PLEKHC1|UNC112|UNC112B|mig-2 | KIND2|MIG2|PLEKHC1|UNC112|UNC112B|mig-2 | |
| Cytomap | 14q22.1 | 14q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fermitin family homolog 2PH domain-containing family C member 1kindlin 2mitogen inducible gene 2 proteinpleckstrin homology domain containing, family C (with FERM domain) member 1pleckstrin homology domain containing, family C member 1 | fermitin family homolog 2PH domain-containing family C member 1kindlin 2mitogen inducible gene 2 proteinpleckstrin homology domain containing, family C (with FERM domain) member 1pleckstrin homology domain containing, family C member 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q96AC1 | Q96AC1 | |
| Ensembl transtripts involved in fusion gene | ENST00000395631, ENST00000341590, ENST00000343279, ENST00000553373, ENST00000399304, ENST00000557255, | ENST00000395631, ENST00000341590, ENST00000343279, ENST00000553373, ENST00000399304, ENST00000557255, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: FERMT2 [Title/Abstract] AND FERMT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA702988 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000395631 | ENST00000395631 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000395631 | ENST00000341590 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000395631 | ENST00000343279 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000395631 | ENST00000553373 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000395631 | ENST00000399304 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000395631 | ENST00000557255 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000341590 | ENST00000395631 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000341590 | ENST00000341590 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000341590 | ENST00000343279 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000341590 | ENST00000553373 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000341590 | ENST00000399304 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000341590 | ENST00000557255 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000343279 | ENST00000395631 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000343279 | ENST00000341590 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000343279 | ENST00000343279 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000343279 | ENST00000553373 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000343279 | ENST00000399304 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000343279 | ENST00000557255 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000553373 | ENST00000395631 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000553373 | ENST00000341590 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000553373 | ENST00000343279 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000553373 | ENST00000553373 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000553373 | ENST00000399304 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000553373 | ENST00000557255 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000399304 | ENST00000395631 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000399304 | ENST00000341590 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000399304 | ENST00000343279 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000399304 | ENST00000553373 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000399304 | ENST00000399304 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000399304 | ENST00000557255 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000557255 | ENST00000395631 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000557255 | ENST00000341590 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000557255 | ENST00000343279 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000557255 | ENST00000553373 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000557255 | ENST00000399304 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
| intron-intron | ENST00000557255 | ENST00000557255 | FERMT2 | chr14 | 53347335 | - | FERMT2 | chr14 | 53349694 | - |
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FusionProtFeatures for FERMT2_FERMT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FERMT2 | FERMT2 |
| Scaffolding protein that enhances integrin activationmediated by TLN1 and/or TLN2, but activates integrins only weaklyby itself. Binds to membranes enriched in phosphoinositides.Enhances integrin-mediated cell adhesion onto the extracellularmatrix and cell spreading; this requires both its ability tointeract with integrins and with phospholipid membranes. Requiredfor the assembly of focal adhesions. Participates in theconnection between extracellular matrix adhesion sites and theactin cytoskeleton and also in the orchestration of actin assemblyand cell shape modulation. Recruits FBLIM1 to focal adhesions.Plays a role in the TGFB1 and integrin signaling pathways.Stabilizes active CTNNB1 and plays a role in the regulation oftranscription mediated by CTNNB1 and TCF7L2/TCF4 and in Wntsignaling. {ECO:0000269|PubMed:12679033,ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030,ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565,ECO:0000269|PubMed:22699938}. | Scaffolding protein that enhances integrin activationmediated by TLN1 and/or TLN2, but activates integrins only weaklyby itself. Binds to membranes enriched in phosphoinositides.Enhances integrin-mediated cell adhesion onto the extracellularmatrix and cell spreading; this requires both its ability tointeract with integrins and with phospholipid membranes. Requiredfor the assembly of focal adhesions. Participates in theconnection between extracellular matrix adhesion sites and theactin cytoskeleton and also in the orchestration of actin assemblyand cell shape modulation. Recruits FBLIM1 to focal adhesions.Plays a role in the TGFB1 and integrin signaling pathways.Stabilizes active CTNNB1 and plays a role in the regulation oftranscription mediated by CTNNB1 and TCF7L2/TCF4 and in Wntsignaling. {ECO:0000269|PubMed:12679033,ECO:0000269|PubMed:18458155, ECO:0000269|PubMed:21325030,ECO:0000269|PubMed:22030399, ECO:0000269|PubMed:22078565,ECO:0000269|PubMed:22699938}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FERMT2_FERMT2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FERMT2_FERMT2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FERMT2_FERMT2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FERMT2_FERMT2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FERMT2 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Hgene | FERMT2 | C0017605 | Angle Closure Glaucoma | 1 | CTD_human |
| Tgene | FERMT2 | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | FERMT2 | C0017605 | Angle Closure Glaucoma | 1 | CTD_human |
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