FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 13287

FusionGeneSummary for FDFT1_CLVS1

check button Fusion gene summary
Fusion gene informationFusion gene name: FDFT1_CLVS1
Fusion gene ID: 13287
HgeneTgene
Gene symbol

FDFT1

CLVS1

Gene ID

2222

157807

Gene namefarnesyl-diphosphate farnesyltransferase 1clavesin 1
SynonymsDGPT|ERG9|SQS|SSC6orf212L|CRALBPL|RLBP1L1
Cytomap

8p23.1

8q12.2-q12.3

Type of geneprotein-codingprotein-coding
Descriptionsqualene synthaseFPP:FPP farnesyltransferasepresqualene-di-diphosphate synthasesqualene synthetaseclavesin-1clathrin vesicle-associated Sec14 protein 1retinaldehyde-binding protein 1-like 1
Modification date2018052320180523
UniProtAcc

P37268

Q8IUQ0

Ensembl transtripts involved in fusion geneENST00000538689, ENST00000220584, 
ENST00000446331, ENST00000443614, 
ENST00000525900, ENST00000528812, 
ENST00000530664, ENST00000528643, 
ENST00000525777, 		ENST00000519846, 
ENST00000518592, ENST00000325897, 
ENST00000518858, 
Fusion gene scores* DoF score8 X 7 X 7=3929 X 7 X 8=504
# samples 129
** MAII scorelog2(12/392*10)=-1.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/504*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FDFT1 [Title/Abstract] AND CLVS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-GJ-A3OU-01AFDFT1chr8

11667359

+CLVS1chr8

62212236

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000538689ENST00000519846FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000538689ENST00000518592FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000538689ENST00000325897FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000538689ENST00000518858FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000220584ENST00000519846FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000220584ENST00000518592FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000220584ENST00000325897FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000220584ENST00000518858FDFT1chr8

11667359

+CLVS1chr8

62212236

+
intron-5UTRENST00000446331ENST00000519846FDFT1chr8

11667359

+CLVS1chr8

62212236

+
intron-intronENST00000446331ENST00000518592FDFT1chr8

11667359

+CLVS1chr8

62212236

+
intron-5UTRENST00000446331ENST00000325897FDFT1chr8

11667359

+CLVS1chr8

62212236

+
intron-intronENST00000446331ENST00000518858FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000443614ENST00000519846FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000443614ENST00000518592FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000443614ENST00000325897FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000443614ENST00000518858FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000525900ENST00000519846FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000525900ENST00000518592FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000525900ENST00000325897FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000525900ENST00000518858FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000528812ENST00000519846FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000528812ENST00000518592FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000528812ENST00000325897FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000528812ENST00000518858FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000530664ENST00000519846FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000530664ENST00000518592FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000530664ENST00000325897FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000530664ENST00000518858FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000528643ENST00000519846FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000528643ENST00000518592FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000528643ENST00000325897FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000528643ENST00000518858FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000525777ENST00000519846FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000525777ENST00000518592FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-5UTRENST00000525777ENST00000325897FDFT1chr8

11667359

+CLVS1chr8

62212236

+
5CDS-intronENST00000525777ENST00000518858FDFT1chr8

11667359

+CLVS1chr8

62212236

+

Top

FusionProtFeatures for FDFT1_CLVS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FDFT1

P37268

CLVS1

Q8IUQ0

Required for normal morphology of late endosomes and/orlysosomes in neurons (By similarity). Binds phosphatidylinositol3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250,ECO:0000269|PubMed:19651769}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FDFT1_CLVS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FDFT1_CLVS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FDFT1PSTPIP1, RUVBL1, SMNDC1, ANXA5, TMEM43, RUVBL2, ARL6IP1, SHPRH, FN1, UBL4A, HDAC10, GLP1R, EGFR, FBXO6, SYVN1, SRPRB, UCHL5, PNKD, P2RX4, STK32C, SERPINA4, HERC2, PTP4A1, DUSP6, USP32, UNC93B1, CNNM1, P2RX1, CD97, POMT2, LMNACLVS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FDFT1_CLVS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FDFT1_CLVS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFDFT1C0024809Marijuana Abuse1CTD_human
HgeneFDFT1C0031391Phencyclidine Abuse1CTD_human
HgeneFDFT1C0236736Cocaine-Related Disorders1CTD_human
HgeneFDFT1C2239176Liver carcinoma1CTD_human