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Fusion gene ID: 13281 |
FusionGeneSummary for FCRL1_ILF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FCRL1_ILF2 | Fusion gene ID: 13281 | Hgene | Tgene | Gene symbol | FCRL1 | ILF2 | Gene ID | 115350 | 3608 |
| Gene name | Fc receptor like 1 | interleukin enhancer binding factor 2 | |
| Synonyms | CD307a|FCRH1|IFGP1|IRTA5 | NF45|PRO3063 | |
| Cytomap | 1q23.1 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | Fc receptor-like protein 1IFGP family protein 1fc receptor homolog 1fcR-like protein 1hIFGP1immune receptor translocation-associated protein 5immunoglobulin superfamily Fc receptor, gp42 | interleukin enhancer-binding factor 2interleukin enhancer binding factor 2, 45kDinterleukin enhancer binding factor 2, 45kDanuclear factor of activated T-cells, 45-kDa | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q96LA6 | Q12905 | |
| Ensembl transtripts involved in fusion gene | ENST00000489998, ENST00000358292, ENST00000368176, ENST00000491942, | ENST00000361891, ENST00000480213, ENST00000368681, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 5 X 2=50 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: FCRL1 [Title/Abstract] AND ILF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FCRL1 | GO:0042113 | B cell activation | 15479727 |
| Tgene | ILF2 | GO:0006351 | transcription, DNA-templated | 11739746 |
| Tgene | ILF2 | GO:0045893 | positive regulation of transcription, DNA-templated | 11739746 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CD703668 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000489998 | ENST00000361891 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| 5UTR-intron | ENST00000489998 | ENST00000480213 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| 5UTR-intron | ENST00000489998 | ENST00000368681 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| In-frame | ENST00000358292 | ENST00000361891 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| 5CDS-intron | ENST00000358292 | ENST00000480213 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| 5CDS-intron | ENST00000358292 | ENST00000368681 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| In-frame | ENST00000368176 | ENST00000361891 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| 5CDS-intron | ENST00000368176 | ENST00000480213 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| 5CDS-intron | ENST00000368176 | ENST00000368681 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| In-frame | ENST00000491942 | ENST00000361891 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| 5CDS-intron | ENST00000491942 | ENST00000480213 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
| 5CDS-intron | ENST00000491942 | ENST00000368681 | FCRL1 | chr1 | 157773635 | - | ILF2 | chr1 | 153637812 | - |
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FusionProtFeatures for FCRL1_ILF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FCRL1 | ILF2 |
| May function as an activating coreceptor in B-cells. Mayfunction in B-cells activation and differentiation.{ECO:0000269|PubMed:15479727}. | Appears to function predominantly as a heterodimericcomplex with ILF3. This complex may regulate transcription of theIL2 gene during T-cell activation. It can also promote theformation of stable DNA-dependent protein kinase holoenzymecomplexes on DNA. Essential for the efficient reshuttling of ILF3(isoform 1 and isoform 2) into the nucleus.{ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746,ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:9442054}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FCRL1_ILF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FCRL1_ENST00000358292_chr1_157773635_-_ILF2_ENST00000361891_chr1_153637812_-_1444nt ATTCTTTTTTTGATGAGAGGCATCTCTAGGTACCATCCCTGACCTGGTCCTCATGCTGCCGAGGCTGTTGCTGTTGATCTGTGCTCCACT CTGTGAACCTGCCGAGCTGTTTTTGATAGCCAGCCCCTCCCATCCCACAGAGGGGAGCCCAGTGACCCTGACGTGTAAGATGCCCTTTCT ACAGAGTTCAGATGCCCAGTTCCAGTTCTGCTTTTTCAGAGACACCCGGGCCTTGGGCCCAGGCTGGAGCAGCTCCCCCAAGCTCCAGAT CGCTGCCATGTGGAAAGAAGACACAGGGTCATACTGGTGCGAGGCACAGACAATGGCGTCCAAAGTCTTGAGGAGCAGGAGATCCCAGAT AAATGTGCACATTTTAACCATGCTGACCAACGAAACTGGCTTTGAAATCAGTTCTTCTGATGCTACAGTGAAGATTCTCATTACAACAGT GCCACCCAATCTTCGAAAACTGGATCCAGAACTCCATTTGGATATCAAAGTATTGCAGAGTGCCTTAGCAGCCATCCGACATGCCCGCTG GTTCGAGGAAAATGCTTCTCAGTCCACAGTTAAAGTTCTCATCAGACTACTGAAGGACTTGAGGATTCGTTTTCCTGGCTTTGAGCCCCT CACACCCTGGATCCTTGACCTACTAGGCCATTATGCTGTGATGAACAACCCCACCAGACAGCCTTTGGCCCTAAACGTTGCATACAGGCG CTGCTTGCAGATTCTGGCTGCAGGACTGTTCCTGCCAGGTTCAGTGGGTATCACTGACCCCTGTGAGAGTGGCAACTTTAGAGTACACAC AGTCATGACCCTAGAACAGCAGGACATGGTCTGCTATACAGCTCAGACTCTCGTCCGAATCCTCTCACATGGTGGCTTTAGGAAGATCCT TGGCCAGGAGGGTGATGCCAGCTATCTTGCTTCTGAAATATCTACCTGGGATGGAGTGATAGTAACACCTTCAGAAAAGGCTTATGAGAA GCCACCAGAGAAGAAGGAAGGAGAGGAAGAAGAGGAGAATACAGAAGAACCACCTCAAGGAGAGGAAGAAGAAAGCATGGAAACTCAGGA GTGACATTCCCTTCACTCCTTTTCCTACCCAAGGGGGAAGACTGGAGCCTAAGCTGCCTGCTACTGGGCTTTACATGGTGACAGACATTT CCGTGGGATAGGGAAGATAGCAGGAAGAAAAGTAAACTCCATAGAAGTGTCATTCCACTGGGTTTTGATATTGGCTTAGCTGCCAGTCTC CCATTTGTGACCTATGCCATCCATCTATAATGGAGGATACCAACATTTCTTCCTAATATTCTATAATCTCCAACTCCTGAAAACCCCTCT CTCAACTAATACTTTGCTGTTGAAATGTTGTGAAATGTTAAGTGTCTGGAAATTTTTTTTTCTAAGAAAAACTATTAAAGTACTTCCTAG >In-frame_FCRL1_ENST00000368176_chr1_157773635_-_ILF2_ENST00000361891_chr1_153637812_-_1460nt CTCGACTCTGAGGTGCATTCTTTTTTTGATGAGAGGCATCTCTAGGTACCATCCCTGACCTGGTCCTCATGCTGCCGAGGCTGTTGCTGT TGATCTGTGCTCCACTCTGTGAACCTGCCGAGCTGTTTTTGATAGCCAGCCCCTCCCATCCCACAGAGGGGAGCCCAGTGACCCTGACGT GTAAGATGCCCTTTCTACAGAGTTCAGATGCCCAGTTCCAGTTCTGCTTTTTCAGAGACACCCGGGCCTTGGGCCCAGGCTGGAGCAGCT CCCCCAAGCTCCAGATCGCTGCCATGTGGAAAGAAGACACAGGGTCATACTGGTGCGAGGCACAGACAATGGCGTCCAAAGTCTTGAGGA GCAGGAGATCCCAGATAAATGTGCACATTTTAACCATGCTGACCAACGAAACTGGCTTTGAAATCAGTTCTTCTGATGCTACAGTGAAGA TTCTCATTACAACAGTGCCACCCAATCTTCGAAAACTGGATCCAGAACTCCATTTGGATATCAAAGTATTGCAGAGTGCCTTAGCAGCCA TCCGACATGCCCGCTGGTTCGAGGAAAATGCTTCTCAGTCCACAGTTAAAGTTCTCATCAGACTACTGAAGGACTTGAGGATTCGTTTTC CTGGCTTTGAGCCCCTCACACCCTGGATCCTTGACCTACTAGGCCATTATGCTGTGATGAACAACCCCACCAGACAGCCTTTGGCCCTAA ACGTTGCATACAGGCGCTGCTTGCAGATTCTGGCTGCAGGACTGTTCCTGCCAGGTTCAGTGGGTATCACTGACCCCTGTGAGAGTGGCA ACTTTAGAGTACACACAGTCATGACCCTAGAACAGCAGGACATGGTCTGCTATACAGCTCAGACTCTCGTCCGAATCCTCTCACATGGTG GCTTTAGGAAGATCCTTGGCCAGGAGGGTGATGCCAGCTATCTTGCTTCTGAAATATCTACCTGGGATGGAGTGATAGTAACACCTTCAG AAAAGGCTTATGAGAAGCCACCAGAGAAGAAGGAAGGAGAGGAAGAAGAGGAGAATACAGAAGAACCACCTCAAGGAGAGGAAGAAGAAA GCATGGAAACTCAGGAGTGACATTCCCTTCACTCCTTTTCCTACCCAAGGGGGAAGACTGGAGCCTAAGCTGCCTGCTACTGGGCTTTAC ATGGTGACAGACATTTCCGTGGGATAGGGAAGATAGCAGGAAGAAAAGTAAACTCCATAGAAGTGTCATTCCACTGGGTTTTGATATTGG CTTAGCTGCCAGTCTCCCATTTGTGACCTATGCCATCCATCTATAATGGAGGATACCAACATTTCTTCCTAATATTCTATAATCTCCAAC TCCTGAAAACCCCTCTCTCAACTAATACTTTGCTGTTGAAATGTTGTGAAATGTTAAGTGTCTGGAAATTTTTTTTTCTAAGAAAAACTA >In-frame_FCRL1_ENST00000491942_chr1_157773635_-_ILF2_ENST00000361891_chr1_153637812_-_1415nt GTACCATCCCTGACCTGGTCCTCATGCTGCCGAGGCTGTTGCTGTTGATCTGTGCTCCACTCTGTGAACCTGCCGAGCTGTTTTTGATAG CCAGCCCCTCCCATCCCACAGAGGGGAGCCCAGTGACCCTGACGTGTAAGATGCCCTTTCTACAGAGTTCAGATGCCCAGTTCCAGTTCT GCTTTTTCAGAGACACCCGGGCCTTGGGCCCAGGCTGGAGCAGCTCCCCCAAGCTCCAGATCGCTGCCATGTGGAAAGAAGACACAGGGT CATACTGGTGCGAGGCACAGACAATGGCGTCCAAAGTCTTGAGGAGCAGGAGATCCCAGATAAATGTGCACATTTTAACCATGCTGACCA ACGAAACTGGCTTTGAAATCAGTTCTTCTGATGCTACAGTGAAGATTCTCATTACAACAGTGCCACCCAATCTTCGAAAACTGGATCCAG AACTCCATTTGGATATCAAAGTATTGCAGAGTGCCTTAGCAGCCATCCGACATGCCCGCTGGTTCGAGGAAAATGCTTCTCAGTCCACAG TTAAAGTTCTCATCAGACTACTGAAGGACTTGAGGATTCGTTTTCCTGGCTTTGAGCCCCTCACACCCTGGATCCTTGACCTACTAGGCC ATTATGCTGTGATGAACAACCCCACCAGACAGCCTTTGGCCCTAAACGTTGCATACAGGCGCTGCTTGCAGATTCTGGCTGCAGGACTGT TCCTGCCAGGTTCAGTGGGTATCACTGACCCCTGTGAGAGTGGCAACTTTAGAGTACACACAGTCATGACCCTAGAACAGCAGGACATGG TCTGCTATACAGCTCAGACTCTCGTCCGAATCCTCTCACATGGTGGCTTTAGGAAGATCCTTGGCCAGGAGGGTGATGCCAGCTATCTTG CTTCTGAAATATCTACCTGGGATGGAGTGATAGTAACACCTTCAGAAAAGGCTTATGAGAAGCCACCAGAGAAGAAGGAAGGAGAGGAAG AAGAGGAGAATACAGAAGAACCACCTCAAGGAGAGGAAGAAGAAAGCATGGAAACTCAGGAGTGACATTCCCTTCACTCCTTTTCCTACC CAAGGGGGAAGACTGGAGCCTAAGCTGCCTGCTACTGGGCTTTACATGGTGACAGACATTTCCGTGGGATAGGGAAGATAGCAGGAAGAA AAGTAAACTCCATAGAAGTGTCATTCCACTGGGTTTTGATATTGGCTTAGCTGCCAGTCTCCCATTTGTGACCTATGCCATCCATCTATA ATGGAGGATACCAACATTTCTTCCTAATATTCTATAATCTCCAACTCCTGAAAACCCCTCTCTCAACTAATACTTTGCTGTTGAAATGTT |
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FusionGenePPI for FCRL1_ILF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FCRL1 | APOD | ILF2 | EEF1G, ILF3, PRKDC, EIF2AK2, CDC5L, MEPCE, HNRNPA1, KHDRBS2, CDK9, XRCC6, XRCC5, TADA2A, H2AFX, HDAC5, NOP56, SF3A2, SIRT7, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, DCUN1D1, CAND1, NEDD8, BIRC2, RPL31, RPS16, RPL6, RPL7, RPL23, DHX9, RPL17, RPL4, SF3B1, RPS13, RPLP0, RPL7A, RPL11, RPL10A, RPS15A, RPL14, RPL19, RPL21, RPL18, RPL8, RPL10, RPS2, RPS23, RPS6, RPL23A, EEF1A1, RPS4X, EIF4A3, RPS26, RPS3, SYNCRIP, MOV10, RPS20, RPS24, RPL5, RPS8, HNRNPH1, HNRNPUL1, SF3B4, RPL9, SRSF7, SRSF5, HNRNPR, SRRM2, TRA2B, HSPA5, SRSF3, PUF60, SUPT5H, DDOST, RCN1, PTBP3, VTN, RANBP2, SON, ALDH18A1, TIMM13, SARS2, MRPL21, RHOB, PC, RPLP0P6, IARS2, MRPS26, TBC1D2, NENF, SSR4, TRIM56, RBM14, SNAP23, SPTAN1, MRPL23, MYOF, PRKCDBP, MRPL50, MIF4GD, FLNA, SCFD1, ZBTB8B, MRPS28, EMC1, PPT2, MRPL17, MPHOSPH6, LBR, MRPL24, SND1, EIF4A1, TOMM22, MRPL28, PTRF, MRPL55, SFXN2, MRPL38, TPM4, PYROXD1, WDR44, MRPS34, DDX28, SOAT1, MTR, LAMP1, TXN2, YES1, SFXN1, LAMTOR3, RAB6C, JUP, MFN1, RAP1B, ICT1, ESR1, MAGOH, YWHAE, FN1, VCAM1, IFIT1, IFIT2, IL7R, UBL4A, ITGA4, CBX6, CBX8, PPID, IGSF8, ICAM1, CSF2, FBXO6, TARDBP, HNRNPU, IGF2BP3, ABCF1, C14orf166, RTCB, NELFB, YBX3, DDX1, DIMT1, EDC4, EIF2B2, EIF2B3, FKBP3, NMT1, RFC4, YBX1, MRE11A, PTBP1, RPA1, RPA2, RPA3, ERG, SMURF2, IVNS1ABP, STAU1, AURKA, HUWE1, CCNDBP1, CUL7, OBSL1, CCDC8, EZH2, SUZ12, EED, BMI1, EP300, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, RAD50, HSPA1A, RUVBL2, ORC2, ORC3, SHMT2, NIP7, KNOP1, RBM28, FTSJ3, FAM120A, STRBP, UPF1, STAU2, ZFR, PABPC4, SRP72, DHX30, ELAVL2, GLYR1, PUM2, MYBBP1A, RPL26L1, MTERF3, CCDC59, RRP8, SRRM1, ZCCHC3, LARP1, LYAR, RRP1B, CEBPZ, NOP2, BRIX1, DDX18, GTPBP4, RPL15, KIAA0020, HNRNPC, DDX31, NVL, YTHDC1, RALY, DICER1, RPF2, PRMT6, NOC2L, RBMXL1, CENPV, PPAN-P2RY11, PTCD1, PAIP1, IMP4, PRKRA, ZNF22, TARBP2, CDC40, OSGEP, ZFR2, LAGE3, SPTBN2, NTRK1, SCARNA22, SREK1, EWSR1, TRIM27, MATR3, KMT2E, NANOG, POU5F1, U2AF2, EGFR, ZNF746, ISY1, RBM3, EIF2AK3, NCL, CYLD, COQ2, COX15, DLD, DLST, DNM1L, HSD17B10, PARK7, PDHA1, SOD1, VDAC1, TRIM25, BRCA1, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FCRL1_ILF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FCRL1_ILF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ILF2 | C0019693 | HIV Infections | 1 | CTD_human |
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