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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13266

FusionGeneSummary for FCHSD2_LDLRAD3

check button Fusion gene summary
Fusion gene informationFusion gene name: FCHSD2_LDLRAD3
Fusion gene ID: 13266
HgeneTgene
Gene symbol

FCHSD2

LDLRAD3

Gene ID

9873

143458

Gene nameFCH and double SH3 domains 2low density lipoprotein receptor class A domain containing 3
SynonymsNWK|SH3MD3LRAD3
Cytomap

11q13.4

11p13

Type of geneprotein-codingprotein-coding
DescriptionF-BAR and double SH3 domains protein 2FCH and double SH3 domains protein 2SH3 multiple domains 3SH3 multiple domains protein 3caromnervous wreck homologlow-density lipoprotein receptor class A domain-containing protein 3
Modification date2018052320180519
UniProtAcc

O94868

Q86YD5

Ensembl transtripts involved in fusion geneENST00000311172, ENST00000409314, 
ENST00000409418, ENST00000458644, 
ENST00000409853, ENST00000409263, 
ENST00000524419, ENST00000528989, 
ENST00000315571, ENST00000529759, 
Fusion gene scores* DoF score29 X 12 X 13=45244 X 2 X 4=32
# samples 334
** MAII scorelog2(33/4524*10)=-3.777060999744
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FCHSD2 [Title/Abstract] AND LDLRAD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-BI-A0VR-01AFCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000311172ENST00000524419FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
intron-3CDSENST00000311172ENST00000528989FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
intron-3CDSENST00000311172ENST00000315571FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
intron-3UTRENST00000311172ENST00000529759FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
Frame-shiftENST00000409314ENST00000524419FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
Frame-shiftENST00000409314ENST00000528989FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
Frame-shiftENST00000409314ENST00000315571FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
5CDS-3UTRENST00000409314ENST00000529759FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
Frame-shiftENST00000409418ENST00000524419FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
Frame-shiftENST00000409418ENST00000528989FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
Frame-shiftENST00000409418ENST00000315571FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
5CDS-3UTRENST00000409418ENST00000529759FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
5UTR-3CDSENST00000458644ENST00000524419FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
5UTR-3CDSENST00000458644ENST00000528989FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
5UTR-3CDSENST00000458644ENST00000315571FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
5UTR-3UTRENST00000458644ENST00000529759FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
5UTR-3CDSENST00000409853ENST00000524419FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
5UTR-3CDSENST00000409853ENST00000528989FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
5UTR-3CDSENST00000409853ENST00000315571FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
5UTR-3UTRENST00000409853ENST00000529759FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
intron-3CDSENST00000409263ENST00000524419FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
intron-3CDSENST00000409263ENST00000528989FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
intron-3CDSENST00000409263ENST00000315571FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+
intron-3UTRENST00000409263ENST00000529759FCHSD2chr11

72851076

-LDLRAD3chr11

36248635

+

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FusionProtFeatures for FCHSD2_LDLRAD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FCHSD2

O94868

LDLRAD3

Q86YD5

May influence APP processing, resulting in a decrease insAPP-alpha production and increased amyloidogenic P3 peptideproduction. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FCHSD2_LDLRAD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FCHSD2_LDLRAD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FCHSD2CCDC158, CCDC85B, MAGI1, CASK, VCP, VCPIP1, HSPA5, SRP72, CFAP36, C2orf73, MSL1, CCT2, SH3BGR, CHKA, C9orf78, HSP90AB1, ITSN1, ITSN2, ELAVL1, DAPP1, WAS, WASL, KIFC3, PDE4DIP, MTUS2, ABCF3, FAM9B, FCHSD2, GOPCLDLRAD3ELAVL1, NXF1, ITCH


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FCHSD2_LDLRAD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FCHSD2_LDLRAD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFCHSD2C3495559Juvenile arthritis1CTD_human
TgeneLDLRAD3C0236969Substance-Related Disorders1CTD_human