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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 13247

FusionGeneSummary for FCHO2_FCHO2

check button Fusion gene summary
Fusion gene informationFusion gene name: FCHO2_FCHO2
Fusion gene ID: 13247
HgeneTgene
Gene symbol

FCHO2

FCHO2

Gene ID

115548

115548

Gene nameFCH domain only 2FCH domain only 2
Synonyms--
Cytomap

5q13.2

5q13.2

Type of geneprotein-codingprotein-coding
DescriptionF-BAR domain only protein 2FCH domain only protein 2F-BAR domain only protein 2FCH domain only protein 2
Modification date2018052320180523
UniProtAcc

Q0JRZ9

Q0JRZ9

Ensembl transtripts involved in fusion geneENST00000341845, ENST00000430046, 
ENST00000512348, ENST00000287761, 
ENST00000341845, ENST00000430046, 
ENST00000512348, ENST00000287761, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 3 X 1=9
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FCHO2 [Title/Abstract] AND FCHO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE005026FCHO2chr5

72373320

+FCHO2chr5

72354258

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000341845ENST00000341845FCHO2chr5

72373320

+FCHO2chr5

72354258

+
In-frameENST00000341845ENST00000430046FCHO2chr5

72373320

+FCHO2chr5

72354258

+
In-frameENST00000341845ENST00000512348FCHO2chr5

72373320

+FCHO2chr5

72354258

+
5CDS-intronENST00000341845ENST00000287761FCHO2chr5

72373320

+FCHO2chr5

72354258

+
In-frameENST00000430046ENST00000341845FCHO2chr5

72373320

+FCHO2chr5

72354258

+
In-frameENST00000430046ENST00000430046FCHO2chr5

72373320

+FCHO2chr5

72354258

+
In-frameENST00000430046ENST00000512348FCHO2chr5

72373320

+FCHO2chr5

72354258

+
5CDS-intronENST00000430046ENST00000287761FCHO2chr5

72373320

+FCHO2chr5

72354258

+
In-frameENST00000512348ENST00000341845FCHO2chr5

72373320

+FCHO2chr5

72354258

+
In-frameENST00000512348ENST00000430046FCHO2chr5

72373320

+FCHO2chr5

72354258

+
In-frameENST00000512348ENST00000512348FCHO2chr5

72373320

+FCHO2chr5

72354258

+
5CDS-intronENST00000512348ENST00000287761FCHO2chr5

72373320

+FCHO2chr5

72354258

+
intron-3CDSENST00000287761ENST00000341845FCHO2chr5

72373320

+FCHO2chr5

72354258

+
intron-3CDSENST00000287761ENST00000430046FCHO2chr5

72373320

+FCHO2chr5

72354258

+
intron-3CDSENST00000287761ENST00000512348FCHO2chr5

72373320

+FCHO2chr5

72354258

+
intron-intronENST00000287761ENST00000287761FCHO2chr5

72373320

+FCHO2chr5

72354258

+

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FusionProtFeatures for FCHO2_FCHO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FCHO2

Q0JRZ9

FCHO2

Q0JRZ9

Functions in an early step of clathrin-mediatedendocytosis. Has both a membrane binding/bending activity and theability to recruit proteins essential to the formation offunctional clathrin-coated pits. Has a lipid-binding activity witha preference for membranes enriched in phosphatidylserine andphosphoinositides (Pi(4,5) biphosphate) like the plasma membrane.Its membrane-bending activity might be important for thesubsequent action of clathrin and adaptors in the formation ofclathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it alsofunctions in the AP-2-independent endocytosis of the LDL receptor.{ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150,ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}. Functions in an early step of clathrin-mediatedendocytosis. Has both a membrane binding/bending activity and theability to recruit proteins essential to the formation offunctional clathrin-coated pits. Has a lipid-binding activity witha preference for membranes enriched in phosphatidylserine andphosphoinositides (Pi(4,5) biphosphate) like the plasma membrane.Its membrane-bending activity might be important for thesubsequent action of clathrin and adaptors in the formation ofclathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it alsofunctions in the AP-2-independent endocytosis of the LDL receptor.{ECO:0000269|PubMed:17540576, ECO:0000269|PubMed:20448150,ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:22323290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHO2chr5:72373320chr5:72354258ENST00000430046+212687_156615811Coiled coilOntology_term=ECO:0000255
HgeneFCHO2chr5:72373320chr5:72354258ENST00000512348+202587_156582778Coiled coilOntology_term=ECO:0000255
HgeneFCHO2chr5:72373320chr5:72354258ENST00000430046+2126434_519615811Compositional biasNote=Ser-rich
HgeneFCHO2chr5:72373320chr5:72354258ENST00000512348+2025434_519582778Compositional biasNote=Ser-rich
HgeneFCHO2chr5:72373320chr5:72354258ENST00000430046+21263_250615811DomainF-BAR
HgeneFCHO2chr5:72373320chr5:72354258ENST00000512348+20253_250582778DomainF-BAR
HgeneFCHO2chr5:72373320chr5:72354258ENST00000430046+21263_274615811RegionNote=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation
HgeneFCHO2chr5:72373320chr5:72354258ENST00000512348+20253_274582778RegionNote=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation
TgeneFCHO2chr5:72373320chr5:72354258ENST00000430046+1526434_519417811Compositional biasNote=Ser-rich
TgeneFCHO2chr5:72373320chr5:72354258ENST00000512348+1425434_519384778Compositional biasNote=Ser-rich
TgeneFCHO2chr5:72373320chr5:72354258ENST00000430046+1526542_809417811DomainMHD
TgeneFCHO2chr5:72373320chr5:72354258ENST00000512348+1425542_809384778DomainMHD

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHO2chr5:72373320chr5:72354258ENST00000430046+2126542_809615811DomainMHD
HgeneFCHO2chr5:72373320chr5:72354258ENST00000512348+2025542_809582778DomainMHD
TgeneFCHO2chr5:72373320chr5:72354258ENST00000430046+152687_156417811Coiled coilOntology_term=ECO:0000255
TgeneFCHO2chr5:72373320chr5:72354258ENST00000512348+142587_156384778Coiled coilOntology_term=ECO:0000255
TgeneFCHO2chr5:72373320chr5:72354258ENST00000430046+15263_250417811DomainF-BAR
TgeneFCHO2chr5:72373320chr5:72354258ENST00000512348+14253_250384778DomainF-BAR
TgeneFCHO2chr5:72373320chr5:72354258ENST00000430046+15263_274417811RegionNote=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation
TgeneFCHO2chr5:72373320chr5:72354258ENST00000512348+14253_274384778RegionNote=Mediates dimerization and binding to membranes enriched in Pi(4%2C5)-P2 and induces their tubulation


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FusionGeneSequence for FCHO2_FCHO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FCHO2_FCHO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FCHO2EPS15, DAB2, AP2M1, SLC25A41, SPC25, NPHP1, XPO1, CAPZA2, CLTB, CLTC, DBN1, MYH9, PICALM, LIMA1, GTSE1, MYO19, RHOU, PTPRG, FCHO1, AP2S1, UBCFCHO2EPS15, DAB2, AP2M1, SLC25A41, SPC25, NPHP1, XPO1, CAPZA2, CLTB, CLTC, DBN1, MYH9, PICALM, LIMA1, GTSE1, MYO19, RHOU, PTPRG, FCHO1, AP2S1, UBC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FCHO2_FCHO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FCHO2_FCHO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource